Promethease 0.1.82
Rs1799971
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs1799971 |
| hapmap | rs1799971 |
| hgdp | rs1799971 |
| ensembl | rs1799971 |
| gopubmed | rs1799971 |
| scholar | rs1799971 |
| rs1799971 | |
| pharmgkb | rs1799971 |
| hgvbaseg2p | rs1799971 |
| medrefsnp | rs1799971 |
| 23andMe | rs1799971 |
| SNP Nexus |
| Gene | OPRM1 |
| Chromosome | 6 |
| Orientation | plus |
| Position | 154402490 |
| Genotype | Effect |
|---|---|
| rs1799971(A;A) | normal |
| rs1799971(A;G) | stronger cravings for alcohol; if alcoholic, naltrexone treatment 2x more successful |
| rs1799971(G;G) | stronger cravings for alcohol; if alcoholic, naltrexone treatment 2x more successful |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs1799971(A;A) | 00 | normal |
| Rs1799971(A;G) | 2.52.5 | stronger cravings for alcohol; if alcoholic, naltrexone treatment 2x more successful |
| Rs1799971(G;G) | 2.62.6 | more pain |
Carriers of at least one rs1799971(G) allele appear to have stronger cravings for alcohol than carriers of two rs1799971(A) alleles, and are thus hypothesized to be more at higher risk for alcoholism.
However, subsequent research results are mixed, and there are other studies both agreeing or disagreeing with this finding [PMID 15525999, PMID 9399694, PMID 12960749]
Among 200+ alcoholics treated with naltrexone, rs1799971(G) carriers receiving the drug (even without behavioral intervention) had an increased percentage of days abstinent (p = .07) and a decreased percentage of heavy drinking days (p = .04) if treated with naltrexone vs placebo, whereas rs1799971(A;A) homozygotes showed no medication differences. Upon treatment with naltrexone, 87% of rs1799971(G) carriers had a good clinical outcome, compared with only 55% of individuals with the (A;A) genotype (odds ratio, 5.75, CI: 1.88-17.54)[PMID 18250251]
This SNP may also influence the response to opioids such as heroin, codeine or morphine.
A study of 200 Chinese heroin addicts found increased frequency for the rs1799971(G) allele compared to non-addicts (40% vs 29%) [PMID 11338173]; but another study of Han Chinese addicts found no difference [PMID 11933204].
spittoon Alcoholism related
- rs1799971(A;A) severe alcoholism 2x
- rs1799732(I;I) severe alcoholism 1.85x
| ? | (A;A) (A;G) (G;G) |
|---|---|
|
| |
| Neighbor | rs17181017 |
| Distance | 1 |
[PMID 19860800] Initial Evidence of an Association Between OPRM1 and Adolescent Alcohol Misuse
| PharmGKB | PA161748324 |
| Name | OPRM1: A118G |
| Annotation | Based on a study at 207 patients treated with morphine, carriers of OPRM1 GG genotype required 93% higher morphine dose compared to carriers of AA genotypes (p = 0.012). |
| Gene | OPRM1 |
| Featue | |
| Evidence | PubMed ID:17156920 |
| Drugs | morphine |
| Diseases | Pain |
| Curation Level | Curated |
[PMID 20112002] A118G Polymorphism of OPRM1 Gene is Associated with Schizophrenia
