Rs1799732

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is asnp
is mentioned by
dbSNPrs1799732
hapmaprs1799732
hgdprs1799732
ensemblrs1799732
gopubmedrs1799732
scholarrs1799732
googlers1799732
pharmgkbrs1799732
hgvbaseg2prs1799732
medrefsnprs1799732
23andMers1799732
SNP Nexus

GeneDRD2
Chromosome11
Orientationminus
Position112851461
GenotypeEffect
rs1799732(-;-)less favorable clinical outcome when on antipsychotics
rs1799732(-;C)1.3x increased adenoma recurrence risk
rs1799732(C;C)normal


Genotypes Magnitude Summary
Rs1799732(-;-) 22 less favorable clinical outcome when on antipsychotics
Rs1799732(-;C) 1.3x increased adenoma recurrence risk
Rs1799732(C;C) normal
rs1799732 is a SNP in the D2 dopamine receptor gene DRD2 gene. Although dbSNP indicates the alleles as (C) or (-) (i.e. a deletion), investigators report the alleles as (C) or (T).

In a study of individuals in the Polyp Prevention Trial with any, multiple (>/=2) or advanced colorectal adenoma recurrence after 4 years, compared to those without adenoma recurrence, rs1799732(C;T) individuals were significantly associated with all adenoma recurrence (odds ratio 1.30, CI: 1.01-1.69). The authors speculate this increased risk of adenoma recurrence (and an association with colorectal cancer) may be related to SNP-associated differences in alcohol and fat intake.[PMID 19065655]

spittoon Alcoholism related

  • rs1799971(A;A) severe alcoholism 2x
  • rs1799732(I;I) severe alcoholism 1.85x


[PMID 19373123] Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution


[PMID 19547807] Association between the DRD2-141C Insertion/Deletion polymorphism and schizophrenia

PharmGKBPA161145171
NameDRD2:-141C Ins/Del
AnnotationMay have a role in determining the response to antipsychotic drugs in schizophrenic inpatients; in schizophrenic patients, the Del allele of the -141C Ins/Del DRD2 polymorphism is associated with a less favorable clinical outcome on antipsychotic therapy than the Ins allele.
GeneDRD2
Featue
EvidenceWeb Resource:http://www.pharmgkb.org/search/annotatedGene/drd2/variant.jsp
Drugs
DiseasesSchizophrenia
Curation LevelIn-Depth


[PMID 19512960] Genetic diagnostics of functional variants of the human dopamine D2 receptor gene

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