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Rs17465637

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0
(A;C) 1,17 1.17x higher risk for myocardial infarction
(C;C) 1,34 1.34x higher risk for myocardial infarction
ReferenceGRCh38 38.1/141
Chromosome1
Position222650187
GeneMIA3
is asnp
is mentioned by
dbSNPrs17465637
ebirs17465637
Exacrs17465637
PheGenIrs17465637
hapmaprs17465637
1000 genomesrs17465637
hgdprs17465637
ensemblrs17465637
gopubmedrs17465637
geneviewrs17465637
scholarrs17465637
googlers17465637
pharmgkbrs17465637
gwascentralrs17465637
openSNPrs17465637
23andMers17465637
23andMe allrs17465637
SNP Nexus

SNPshotrs17465637
SNPdbers17465637
MSV3drs17465637
GWAS Ctlgrs17465637
GMAF0.4518
Max Magnitude1,34
",34" can not be assigned to a declared number type with value 1.
? (A;A) (A;C) (C;C) 28
rs17465637 is a SNP found to be associated with heart disease by the German MI (Myocardial infarction) Family Study group [PMID 17634449OA-icon.png]

[PMID 21264445] This 2011 study concluded that the only MIA3 gene SNP to be associated with increased risk for myocardial infarction is rs17465637, with an odds ratio of 1.17 (CI: 1.04-1.32) and 1.37 (CI: 1.08-1.74) for carriers of one or two (C) alleles, respectively.

23andMe blog coronary artery disease and heart attack

SNP Risk Version Effect

GWAS snp
PMID [PMID 19198609OA-icon.png]
Trait Myocardial infarction (early onset)
Title Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
Risk Allele C
P-val 1E-9
Odds Ratio 1.14 [1.10-1.19]




[PMID 21463265OA-icon.png] Association of SNP rs17465637 on Chromosome 1q41 and rs599839 on 1p13.3 with Myocardial Infarction in an American Caucasian Population

GWAS snp
PMID [PMID 21378990OA-icon.png]
Trait
Title Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Risk Allele C
P-val 1E-8
Odds Ratio 1.1400 [1.09-1.20]


[PMID 22856164] [Evaluation of association between 9 genetic polymorphism and myocardial infarction in the Siberian population]


[PMID 18654002] Validation of the association of genetic variants on chromosome 9p21 and 1q41 with myocardial infarction in a Japanese population.


[PMID 18979498OA-icon.png] The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts.


[PMID 19750184OA-icon.png] Genome-wide association studies for atherosclerotic vascular disease and its risk factors.


[PMID 19956433OA-icon.png] Genetics of coronary artery disease: focus on genome-wide association studies.


[PMID 20017983OA-icon.png] Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort.


[PMID 20098575OA-icon.png] Genetics and cardiovascular disease: Design and development of a DNA biobank.


[PMID 20835900OA-icon.png] Genetics of diabetes complications.


[PMID 21804106OA-icon.png] Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration.


[PMID 21984477] Genomic risk variants at 1p13.3, 1q41, and 3q22.3 are associated with subsequent cardiovascular outcomes in healthy controls and in established coronary artery disease.


[PMID 22577832] Association Study of MIA3 rs17465637 Polymorphism with Cardiovascular Disease in Rheumatoid Arthritis Patients.


GET Evidence
rs17465637
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.554688
summary



[PMID 24125424] Meta-analysis identifies robust association between SNP rs17465637 in MIA3 on chromosome 1q41 and coronary artery disease