Rs11206510
| Orientation | plus |
| is a | snp |
| is | mentioned by |
| dbSNP | rs11206510 |
| PheGenI | rs11206510 |
| nextbio | rs11206510 |
| hapmap | rs11206510 |
| 1000 genomes | rs11206510 |
| hgdp | rs11206510 |
| ensembl | rs11206510 |
| gopubmed | rs11206510 |
| geneview | rs11206510 |
| scholar | rs11206510 |
| rs11206510 | |
| pharmgkb | rs11206510 |
| gwascentral | rs11206510 |
| openSNP | rs11206510 |
| 23andMe | rs11206510 |
| 23andMe all | rs11206510 |
| SNP Nexus | |
| SNPshot | rs11206510 |
| SNPdbe | rs11206510 |
| MSV3d | rs11206510 |
| Chromosome | 1 |
| Orientation | plus |
| GMAF | 0.12 |
| Position | 55496039 |
| Reference | GRCh37 37.1/131 |
| Max Magnitude | 0 |
| Geno | Mag | Summary |
|---|---|---|
| (T;T) | 0 |
| Make rs11206510(C;C) |
| Make rs11206510(C;T) |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
SNP Risk Version Effect
- rs646776 T 1.19
- rs17465637 C 1.14
- rs1746048 C 1.17
- rs6725887 C 1.17
- rs11206510 T 1.15
- rs3184504 T 1.13
- rs2306374 C 1.15
- rs3782886 C 1.44
| GWAS snp | |
|---|---|
| PMID | [PMID 19198609] |
| Trait | Myocardial infarction (early onset) |
| Title | Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants |
| Risk Allele | T |
| P-val | 1E-8 |
| Odds Ratio | 1.15 [1.10-1.21] |
| GWAS snp | |
|---|---|
| PMID | [PMID 19060906] |
| Trait | LDL cholesterol |
| Title | Common variants at 30 loci contribute to polygenic dyslipidemia |
| Risk Allele | C |
| P-val | 4E-8 |
| Odds Ratio | 0.09 [0.05-0.13] SD decrease |
| GWAS snp | |
|---|---|
| PMID | [PMID 18193043] |
| Trait | LDL cholesterol |
| Title | Newly identified loci that influence lipid concentrations and risk of coronary artery disease |
| Risk Allele | T |
| P-val | 3.9999999999999998E-11 |
| Odds Ratio | 3.04 [NR] mg/dl higher |
[PMID 20576952] Minor Allele C of Chromosome 1p32 Single Nucleotide Polymorphism rs11206510 Confers Risk of Ischemic Stroke in the Chinese Han Population
[PMID 20699424] Effects of PCSK9 genetic variants on plasma LDL cholesterol levels and risk of premature myocardial infarction in the Italian population
| GWAS snp | |
|---|---|
| PMID | [PMID 20864672] |
| Trait | |
| Title | Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease |
| Risk Allele | T |
| P-val | 1E-10 |
| Odds Ratio | 0.03 [0.02-0.04] unit increase |
| GWAS snp | |
|---|---|
| PMID | [PMID 21378990] |
| Trait | |
| Title | Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease |
| Risk Allele | T |
| P-val | 9E-8 |
| Odds Ratio | 1.0800 [1.05-1.11] |
[PMID 18193044] Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
[PMID 18852197] Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.
[PMID 19060910] Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
[PMID 19060911] Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
[PMID 19185284] Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study.
[PMID 19435741] Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people.
[PMID 19750184] Genome-wide association studies for atherosclerotic vascular disease and its risk factors.
[PMID 19951432] Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.
[PMID 19956433] Genetics of coronary artery disease: focus on genome-wide association studies.
[PMID 20018036] Using a latent growth curve model for an integrative assessment of the effects of genetic and environmental factors on multiple phenotypes.
[PMID 20835900] Genetics of diabetes complications.
[PMID 22152955] Genetic susceptibility to coronary heart disease in type 2 diabetes: 3 independent studies.
| GET Evidence | |
|---|---|
| rs11206510 | |
| aa_change | |
| aa_change_short | |
| impact | pathogenic |
| qualified_impact | Insufficiently evaluated pathogenic |
| overall_frequency | 0.117188 |
| summary | |
[PMID 23098650] Impact of variants within seven candidate genes on statin treatment efficacy
