23andMe blog coronary artery disease and heart attack
SNP Risk Version Effect
- rs646776 T 1.19
- rs17465637 C 1.14
- rs1746048 C 1.17
- rs6725887 C 1.17
- rs11206510 T 1.15
- rs3184504 T 1.13
- rs2306374 C 1.15
- rs3782886 C 1.44
|Trait||Myocardial infarction (early onset)|
|Title||Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants|
|Odds Ratio||1.15 [1.10-1.21]|
|Title||Common variants at 30 loci contribute to polygenic dyslipidemia|
|Odds Ratio||0.09 [0.05-0.13] SD decrease|
|Title||Newly identified loci that influence lipid concentrations and risk of coronary artery disease|
|Odds Ratio||3.04 [NR] mg/dl higher|
[PMID 20576952] Minor Allele C of Chromosome 1p32 Single Nucleotide Polymorphism rs11206510 Confers Risk of Ischemic Stroke in the Chinese Han Population
[PMID 20699424] Effects of PCSK9 genetic variants on plasma LDL cholesterol levels and risk of premature myocardial infarction in the Italian population
|Title||Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease|
|Odds Ratio||0.03 [0.02-0.04] unit increase|
|Title||Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease|
|Odds Ratio||1.0800 [1.05-1.11]|
[PMID 18193044] Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
[PMID 18852197] Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.
[PMID 19060910] Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
[PMID 19060911] Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
[PMID 19185284] Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study.
[PMID 19435741] Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people.
[PMID 19750184] Genome-wide association studies for atherosclerotic vascular disease and its risk factors.
[PMID 19951432] Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.
[PMID 19956433] Genetics of coronary artery disease: focus on genome-wide association studies.
[PMID 20018036] Using a latent growth curve model for an integrative assessment of the effects of genetic and environmental factors on multiple phenotypes.
[PMID 20835900] Genetics of diabetes complications.
[PMID 22152955] Genetic susceptibility to coronary heart disease in type 2 diabetes: 3 independent studies.
|qualified_impact||Insufficiently evaluated pathogenic|
[PMID 23098650] Impact of variants within seven candidate genes on statin treatment efficacy
[PMID 23380588] Association between PCSK9 and LDLR gene polymorphisms with coronary heart disease: case-control study and meta-analysis.