Rs1344706

Orientation

minus

is a	snp
is	mentioned by
dbSNP	rs1344706
PheGenI	rs1344706
nextbio	rs1344706
hapmap	rs1344706
1000 genomes	rs1344706
hgdp	rs1344706
ensembl	rs1344706
gopubmed	rs1344706
geneview	rs1344706
scholar	rs1344706
google	rs1344706
pharmgkb	rs1344706
gwascentral	rs1344706
openSNP	rs1344706
23andMe	rs1344706
23andMe all	rs1344706
SNP Nexus
SNPshot	rs1344706
SNPdbe	rs1344706
MSV3d	rs1344706

Gene

ZNF804A

Chromosome

2

Orientation

minus

GMAF

0.3452

Position

185778428

Reference

GRCh37 37.1/131

Max Magnitude

1.2

Geno	Mag	Summary
(G;G)	0	normal
(G;T)	1.1	1.1x increased risk for schizophrenia
(T;T)	1.2	1.2x increased risk for schizophrenia

?	(G;G) (G;T) (T;T)	28

rs1344706 is a SNP in the ZNF804A gene, and it is probably the first SNP to have been reported as achieving genome-wide significance for psychosis.

[PMID 20688871] Reviews the literature, and concludes that rs1344706 is "robustly, if modestly" associated with increased risk for schizophrenia.

[PMID 18677311] A genome-wide association study of schizophrenia (479 cases, 2,937 controls) followed by additional testing and a meta-analysis concluded that the strongest evidence for association was around ZNF804A (rs1344706; p = 1.61 x 10e-7) and that the finding was strengthened when the affected phenotype included bipolar disorder (p = 9.96 x 10e-9).

GWAS
SNP	rs1344706
PubMedID	[PMID 18677311]
Condition	Schizophrenia
Gene	ZNF804A
Risk Allele	T
pValue	2.00E-007
OR	1.12
95% CI

[PMID 19407193] Neural mechanisms of a genome-wide supported psychosis variant

OMIM	181500
Desc	SCHIZOPHRENIA; SCZD
Variant
Related	also

OMIM	612361
Desc	SCHIZOPHRENIA 13
Variant
Related	also

[PMID 19844207] Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample

[PMID 20603450] Psychosis Susceptibility Gene ZNF804A and Cognitive Performance in Schizophrenia

[PMID 20664580] A Schizophrenia Risk Gene, ZNF804A, Influences Neuroanatomical and Neurocognitive Phenotypes

[PMID 20688871] The Psychosis Susceptibility Gene ZNF804A: Associations, Functions, and Phenotypes

[PMID 20946959] Cognitive state and connectivity effects of the genome-wide significant psychosis variant in ZNF804A

[PMID 21234901] Evaluation of risk loci for schizophrenia derived from genome-wide association studies in a German population

[PMID 21525856] The ZNF804A Gene: Characterization of a Novel Neural Risk Mechanism for the Major Psychoses

[PMID 21890790] Allelic Differences Between Han Chinese and Europeans for Functional Variants in ZNF804A and Their Association With Schizophrenia

[PMID 21276201] Bipolar disorder risk alleles in adult ADHD patients

[PMID 21988329] A Polymerase Chain Reaction-Restriction Fragment Length Polymorphism Method for Screening ZNF804A Gene Polymorphism (rs1344706) in Patients with Schizophrenia: A Significant Association

[PMID 21993378] Is the conserved mammalian region of ZNF804A locus associated with schizophrenia? A population-based genetics analysis

[PMID 22042765] Partial support for ZNF804A genotype-dependent alterations in prefrontal connectivity

[PMID 22373944] Evidence of IQ-Modulated Association Between ZNF804A Gene Polymorphism and Cognitive Function in Schizophrenia Patients

[PMID 19693005] Executive function, neural circuitry, and genetic mechanisms in schizophrenia.

[PMID 19721717] Apoptotic engulfment pathway and schizophrenia.

[PMID 19911060] Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.

[PMID 20048749] Expanding the range of ZNF804A variants conferring risk of psychosis.

[PMID 20231838] Effects of a genome-wide supported psychosis risk variant on neural activation during a theory-of-mind task.

[PMID 20368704] Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder.

[PMID 20485477] New Genetic Findings in Schizophrenia: Is there Still Room for the Dopamine Hypothesis of Schizophrenia?

[PMID 20934520] ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia.

[PMID 20957649] The impact of a genome-wide supported psychosis variant in the ZNF804A gene on memory function in schizophrenia.

[PMID 21040459] ZNF804A may be associated with executive control of attention.

[PMID 21302348] Evaluation of risk loci for schizophrenia derived from genome-wide association studies in a German population.

[PMID 21349497] Evidence of sex-modulated association of ZNF804A with schizophrenia.

[PMID 21457757] Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene.

[PMID 21767209] ANK3, CACNA1C and ZNF804A gene variants in bipolar disorders and psychosis subphenotype.

[PMID 21810628] Altered cortical network dynamics: a potential intermediate phenotype for schizophrenia and association with ZNF804A.

[PMID 21892778] The schizophrenia risk gene ZNF804A influences the antipsychotic response of positive schizophrenia symptoms.

[PMID 21911029] Association of the ZNF804A gene polymorphism rs1344706 with white matter density changes in Chinese schizophrenia.

[PMID 22328493] Genome-wide supported psychosis risk variant in ZNF804A gene and impact on cortico-limbic WM integrity in schizophrenia.

[PMID 22384243] ZNF804a regulates expression of the schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2.

[PMID 22416237] The effects of psychosis risk variants on brain connectivity: a review.

[PMID 22425527] Association analysis of ZNF804A (zinc finger protein 804A) rs1344706 with therapeutic response to atypical antipsychotics in first-episode Chinese patients with schizophrenia.

GET Evidence
rs1344706
aa_change
aa_change_short
impact	pathogenic
qualified_impact	Insufficiently evaluated pathogenic
overall_frequency	0.273438
summary

[PMID 23212061] Evidence That Schizophrenia Risk Variation in the ZNF804A Gene Exerts Its Effects During Fetal Brain Development

[PMID 23351715] Investigation of the ZNF804A gene polymorphism with genetic risk for bipolar disorder in attention deficit hyperactivity disorder

[PMID 23562677] ZNF804A and cortical thickness in schizophrenia and bipolar disorder