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From SNPedia

Geno Mag Summary
(G;G) 0 normal
(G;T) 1.1 1.1x increased risk for schizophrenia
(T;T) 1.2 1.2x increased risk for schizophrenia
ReferenceGRCh38 38.1/142
is asnp
is mentioned by
1000 genomesrs1344706
23andMe allrs1344706
SNP Nexus

GWAS Ctlgrs1344706
Max Magnitude1.2
? (G;G) (G;T) (T;T) 28
rs1344706 is a SNP in the ZNF804A gene, and it is probably the first SNP to have been reported as achieving genome-wide significance for psychosis.

[PMID 20688871OA-icon.png] Reviews the literature, and concludes that rs1344706 is "robustly, if modestly" associated with increased risk for schizophrenia.

[PMID 18677311] A genome-wide association study of schizophrenia (479 cases, 2,937 controls) followed by additional testing and a meta-analysis concluded that the strongest evidence for association was around ZNF804A (rs1344706; p = 1.61 x 10e-7) and that the finding was strengthened when the affected phenotype included bipolar disorder (p = 9.96 x 10e-9).

SNP rs1344706
PubMedID [PMID 18677311]
Condition Schizophrenia
Gene ZNF804A
Risk Allele T
pValue 2.00E-007
OR 1.12
95% CI

[PMID 19407193] Neural mechanisms of a genome-wide supported psychosis variant

[PMID 19844207OA-icon.png] Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample

[PMID 20603450] Psychosis Susceptibility Gene ZNF804A and Cognitive Performance in Schizophrenia

[PMID 20664580OA-icon.png] A Schizophrenia Risk Gene, ZNF804A, Influences Neuroanatomical and Neurocognitive Phenotypes

[PMID 20688871OA-icon.png] The Psychosis Susceptibility Gene ZNF804A: Associations, Functions, and Phenotypes

[PMID 20946959] Cognitive state and connectivity effects of the genome-wide significant psychosis variant in ZNF804A

[PMID 21234901] Evaluation of risk loci for schizophrenia derived from genome-wide association studies in a German population

[PMID 21525856OA-icon.png] The ZNF804A Gene: Characterization of a Novel Neural Risk Mechanism for the Major Psychoses

[PMID 21890790] Allelic Differences Between Han Chinese and Europeans for Functional Variants in ZNF804A and Their Association With Schizophrenia

[PMID 21276201] Bipolar disorder risk alleles in adult ADHD patients

[PMID 21988329] A Polymerase Chain Reaction-Restriction Fragment Length Polymorphism Method for Screening ZNF804A Gene Polymorphism (rs1344706) in Patients with Schizophrenia: A Significant Association

[PMID 21993378] Is the conserved mammalian region of ZNF804A locus associated with schizophrenia? A population-based genetics analysis

[PMID 22042765] Partial support for ZNF804A genotype-dependent alterations in prefrontal connectivity

[PMID 22373944OA-icon.png] Evidence of IQ-Modulated Association Between ZNF804A Gene Polymorphism and Cognitive Function in Schizophrenia Patients

[PMID 19693005OA-icon.png] Executive function, neural circuitry, and genetic mechanisms in schizophrenia.

[PMID 19721717OA-icon.png] Apoptotic engulfment pathway and schizophrenia.

[PMID 19911060OA-icon.png] Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.

[PMID 20048749OA-icon.png] Expanding the range of ZNF804A variants conferring risk of psychosis.

[PMID 20231838] Effects of a genome-wide supported psychosis risk variant on neural activation during a theory-of-mind task.

[PMID 20368704OA-icon.png] Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder.

[PMID 20485477OA-icon.png] New Genetic Findings in Schizophrenia: Is there Still Room for the Dopamine Hypothesis of Schizophrenia?

[PMID 20934520] ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia.

[PMID 20957649] The impact of a genome-wide supported psychosis variant in the ZNF804A gene on memory function in schizophrenia.

[PMID 21040459] ZNF804A may be associated with executive control of attention.

[PMID 21302348] Evaluation of risk loci for schizophrenia derived from genome-wide association studies in a German population.

[PMID 21349497] Evidence of sex-modulated association of ZNF804A with schizophrenia.

[PMID 21457757] Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene.

[PMID 21767209] ANK3, CACNA1C and ZNF804A gene variants in bipolar disorders and psychosis subphenotype.

[PMID 21810628] Altered cortical network dynamics: a potential intermediate phenotype for schizophrenia and association with ZNF804A.

[PMID 21892778] The schizophrenia risk gene ZNF804A influences the antipsychotic response of positive schizophrenia symptoms.

[PMID 21911029] Association of the ZNF804A gene polymorphism rs1344706 with white matter density changes in Chinese schizophrenia.

[PMID 22328493] Genome-wide supported psychosis risk variant in ZNF804A gene and impact on cortico-limbic WM integrity in schizophrenia.

[PMID 22384243OA-icon.png] ZNF804a regulates expression of the schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2.

[PMID 22416237OA-icon.png] The effects of psychosis risk variants on brain connectivity: a review.

[PMID 22425527] Association analysis of ZNF804A (zinc finger protein 804A) rs1344706 with therapeutic response to atypical antipsychotics in first-episode Chinese patients with schizophrenia.

GET Evidence
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.273438

[PMID 23212061] Evidence That Schizophrenia Risk Variation in the ZNF804A Gene Exerts Its Effects During Fetal Brain Development

[PMID 23351715OA-icon.png] Investigation of the ZNF804A gene polymorphism with genetic risk for bipolar disorder in attention deficit hyperactivity disorder

[PMID 23562677] ZNF804A and cortical thickness in schizophrenia and bipolar disorder

[PMID 24066410] Evaluation of the relationship between the ZNF804A single nucleotide polymorphism rs1344706 A/C variant and schizophrenia subtype in Han Chinese patients

[PMID 24247043OA-icon.png] Further Evidence for The Impact of a Genome-Wide Supported Psychosis Risk Variant in ZNF804A on The Theory of Mind Network

[PMID 24315717OA-icon.png] Evidence of allelic imbalance in the schizophrenia susceptibility gene ZNF804A in human dorsolateral prefrontal cortex

[PMID 24424391OA-icon.png] Effects of ZNF804A on auditory P300 response in schizophrenia

[PMID 24462263] Allelic imbalance associated with the schizophrenia risk SNP rs1344706 indicates a cis-acting variant in ZNF804A

[PMID 22005930OA-icon.png] Genome-wide association study of Alzheimer's disease with psychotic symptoms.

[PMID 22775511] ZNF804A rs1344706 variant and schizophrenia in a Romanian population from Cluj Napoca.

[PMID 22781169OA-icon.png] Evidence for the involvement of ZNF804A in cognitive processes of relevance to reading and spelling.

[PMID 22840435OA-icon.png] An investigation of a genomewide supported psychosis variant in ZNF804A and white matter integrity in the human brain.

[PMID 22871346] Further evidence for the association of genetic variants of ZNF804A with schizophrenia and a meta-analysis for genome-wide significance variant rs1344706.

[PMID 22887939] ZNF804A and schizophrenia susceptibility in Asian populations.

[PMID 23147122OA-icon.png] No association of ZNF804A rs1344706 with white matter integrity in schizophrenia: a tract-based spatial statistics study.

[PMID 23295962OA-icon.png] ZNF804A genotype modulates neural activity during working memory for faces.

[PMID 23590871] Association of rs1344706 in the ZNF804A gene with schizophrenia in a case/control sample from Indonesia.

[PMID 25162540] Expression of ZNF804A in Human Brain and Alterations in Schizophrenia, Bipolar Disorder, and Major Depressive Disorder: A Novel Transcript Fetally Regulated by the Psychosis Risk Variant rs1344706

[PMID 25757652] Modulation of hippocampal theta and hippocampal-prefrontal cortex function by a schizophrenia risk gene

[PMID 25921517] ZNF804A rs1344706 is associated with cortical thickness, surface area, and cortical volume of the unmedicated first episode schizophrenia and healthy controls

[PMID 26382569] Replication of ZNF804A gene variant associations with risk of heroin addiction