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Rs1344706

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Geno Mag Summary
(G;G) 0 normal
(G;T) 1.1 1.1x increased risk for schizophrenia
(T;T) 1.2 1.2x increased risk for schizophrenia
ReferenceGRCh38 38.1/141
Chromosome2
Position184913701
GeneZNF804A
is asnp
is mentioned by
dbSNPrs1344706
PheGenIrs1344706
nextbiors1344706
hapmaprs1344706
1000 genomesrs1344706
hgdprs1344706
ensemblrs1344706
gopubmedrs1344706
geneviewrs1344706
scholarrs1344706
googlers1344706
pharmgkbrs1344706
gwascentralrs1344706
openSNPrs1344706
23andMers1344706
23andMe allrs1344706
SNP Nexus

SNPshotrs1344706
SNPdbers1344706
MSV3drs1344706
GMAF0.3453
Max Magnitude1.2
? (G;G) (G;T) (T;T) 28
rs1344706 is a SNP in the ZNF804A gene, and it is probably the first SNP to have been reported as achieving genome-wide significance for psychosis.

[PMID 20688871OA-icon.png] Reviews the literature, and concludes that rs1344706 is "robustly, if modestly" associated with increased risk for schizophrenia.

[PMID 18677311] A genome-wide association study of schizophrenia (479 cases, 2,937 controls) followed by additional testing and a meta-analysis concluded that the strongest evidence for association was around ZNF804A (rs1344706; p = 1.61 x 10e-7) and that the finding was strengthened when the affected phenotype included bipolar disorder (p = 9.96 x 10e-9).

GWAS
SNP rs1344706
PubMedID [PMID 18677311]
Condition Schizophrenia
Gene ZNF804A
Risk Allele T
pValue 2.00E-007
OR 1.12
95% CI


[PMID 19407193] Neural mechanisms of a genome-wide supported psychosis variant

OMIM181500
DescSCHIZOPHRENIA; SCZD
Variant
Relatedalso
OMIM612361
DescSCHIZOPHRENIA 13
Variant
Relatedalso
[PMID 19844207OA-icon.png] Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample



[PMID 20603450] Psychosis Susceptibility Gene ZNF804A and Cognitive Performance in Schizophrenia

[PMID 20664580OA-icon.png] A Schizophrenia Risk Gene, ZNF804A, Influences Neuroanatomical and Neurocognitive Phenotypes

[PMID 20688871OA-icon.png] The Psychosis Susceptibility Gene ZNF804A: Associations, Functions, and Phenotypes

[PMID 20946959] Cognitive state and connectivity effects of the genome-wide significant psychosis variant in ZNF804A


[PMID 21234901] Evaluation of risk loci for schizophrenia derived from genome-wide association studies in a German population


[PMID 21525856OA-icon.png] The ZNF804A Gene: Characterization of a Novel Neural Risk Mechanism for the Major Psychoses


[PMID 21890790] Allelic Differences Between Han Chinese and Europeans for Functional Variants in ZNF804A and Their Association With Schizophrenia


[PMID 21276201] Bipolar disorder risk alleles in adult ADHD patients


[PMID 21988329] A Polymerase Chain Reaction-Restriction Fragment Length Polymorphism Method for Screening ZNF804A Gene Polymorphism (rs1344706) in Patients with Schizophrenia: A Significant Association


[PMID 21993378] Is the conserved mammalian region of ZNF804A locus associated with schizophrenia? A population-based genetics analysis


[PMID 22042765] Partial support for ZNF804A genotype-dependent alterations in prefrontal connectivity


[PMID 22373944OA-icon.png] Evidence of IQ-Modulated Association Between ZNF804A Gene Polymorphism and Cognitive Function in Schizophrenia Patients

[PMID 19693005OA-icon.png] Executive function, neural circuitry, and genetic mechanisms in schizophrenia.

[PMID 19721717OA-icon.png] Apoptotic engulfment pathway and schizophrenia.

[PMID 19911060OA-icon.png] Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.

[PMID 20048749OA-icon.png] Expanding the range of ZNF804A variants conferring risk of psychosis.

[PMID 20231838] Effects of a genome-wide supported psychosis risk variant on neural activation during a theory-of-mind task.

[PMID 20368704OA-icon.png] Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder.

[PMID 20485477OA-icon.png] New Genetic Findings in Schizophrenia: Is there Still Room for the Dopamine Hypothesis of Schizophrenia?

[PMID 20934520] ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia.

[PMID 20957649] The impact of a genome-wide supported psychosis variant in the ZNF804A gene on memory function in schizophrenia.

[PMID 21040459] ZNF804A may be associated with executive control of attention.

[PMID 21302348] Evaluation of risk loci for schizophrenia derived from genome-wide association studies in a German population.

[PMID 21349497] Evidence of sex-modulated association of ZNF804A with schizophrenia.

[PMID 21457757] Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene.

[PMID 21767209] ANK3, CACNA1C and ZNF804A gene variants in bipolar disorders and psychosis subphenotype.

[PMID 21810628] Altered cortical network dynamics: a potential intermediate phenotype for schizophrenia and association with ZNF804A.

[PMID 21892778] The schizophrenia risk gene ZNF804A influences the antipsychotic response of positive schizophrenia symptoms.

[PMID 21911029] Association of the ZNF804A gene polymorphism rs1344706 with white matter density changes in Chinese schizophrenia.

[PMID 22328493] Genome-wide supported psychosis risk variant in ZNF804A gene and impact on cortico-limbic WM integrity in schizophrenia.

[PMID 22384243OA-icon.png] ZNF804a regulates expression of the schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2.

[PMID 22416237OA-icon.png] The effects of psychosis risk variants on brain connectivity: a review.

[PMID 22425527] Association analysis of ZNF804A (zinc finger protein 804A) rs1344706 with therapeutic response to atypical antipsychotics in first-episode Chinese patients with schizophrenia.


GET Evidence
rs1344706
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.273438
summary



[PMID 23212061] Evidence That Schizophrenia Risk Variation in the ZNF804A Gene Exerts Its Effects During Fetal Brain Development


[PMID 23351715OA-icon.png] Investigation of the ZNF804A gene polymorphism with genetic risk for bipolar disorder in attention deficit hyperactivity disorder


[PMID 23562677] ZNF804A and cortical thickness in schizophrenia and bipolar disorder


[PMID 24066410] Evaluation of the relationship between the ZNF804A single nucleotide polymorphism rs1344706 A/C variant and schizophrenia subtype in Han Chinese patients


[PMID 24247043] Further Evidence for The Impact of a Genome-Wide Supported Psychosis Risk Variant in ZNF804A on The Theory of Mind Network


[PMID 24315717] Evidence of allelic imbalance in the schizophrenia susceptibility gene ZNF804A in human dorsolateral prefrontal cortex


[PMID 24424391OA-icon.png] Effects of ZNF804A on auditory P300 response in schizophrenia


[PMID 24462263] Allelic imbalance associated with the schizophrenia risk SNP rs1344706 indicates a cis-acting variant in ZNF804A


[PMID 22005930OA-icon.png] Genome-wide association study of Alzheimer's disease with psychotic symptoms.


[PMID 22775511] ZNF804A rs1344706 variant and schizophrenia in a Romanian population from Cluj Napoca.


[PMID 22781169OA-icon.png] Evidence for the involvement of ZNF804A in cognitive processes of relevance to reading and spelling.


[PMID 22840435OA-icon.png] An investigation of a genomewide supported psychosis variant in ZNF804A and white matter integrity in the human brain.


[PMID 22871346] Further evidence for the association of genetic variants of ZNF804A with schizophrenia and a meta-analysis for genome-wide significance variant rs1344706.


[PMID 22887939] ZNF804A and schizophrenia susceptibility in Asian populations.


[PMID 23147122] No association of ZNF804A rs1344706 with white matter integrity in schizophrenia: a tract-based spatial statistics study.


[PMID 23295962OA-icon.png] ZNF804A genotype modulates neural activity during working memory for faces.


[PMID 23590871] Association of rs1344706 in the ZNF804A gene with schizophrenia in a case/control sample from Indonesia.