Rs12979860

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Geno Mag Summary
(C;C) 2 ~80% of such hepatitis C patients respond to treatment
(C;T) 2.5 ~20-40% of such hepatitis C patients respond to treatment
(T;T) 3 ~20-25% of such hepatitis C patients respond to treatment
ReferenceGRCh38 38.1/141
Chromosome19
Position39248147
GeneIFNL4
is asnp
is mentioned by
dbSNPrs12979860
PheGenIrs12979860
nextbiors12979860
hapmaprs12979860
1000 genomesrs12979860
hgdprs12979860
ensemblrs12979860
gopubmedrs12979860
geneviewrs12979860
scholarrs12979860
googlers12979860
pharmgkbrs12979860
gwascentralrs12979860
openSNPrs12979860
23andMers12979860
23andMe allrs12979860
SNP Nexus

SNPshotrs12979860
SNPdbers12979860
MSV3drs12979860
GMAF0.3388
Max Magnitude3
? (C;C) (C;T) (T;T) 28
rs12979860 is a SNP near the IL28B gene, encoding interferon-lambda-3 (IFN-lambda-3).

Several studies now indicate that this SNP predicts hepatitis C treatment-induced viral clearance. It is associated with an approximately twofold change in response to pegylated interferon-alpha (PEG-IFN-alpha) plus ribavirin (RBV) treatment, both among patients of European ancestry (p = 1.06 x 10e-25) and African-Americans (p = 2.06 x 10e-3). These studies indicate that the virus was eradicated in ~80% of (C;C) patients, compared to only about 25% of those with (T;T), while (C;T) response was intermediate.[PMID 19684573, PMID 19749758, PMID 19749757]

23andMe blog

rs8099917(C) less likely to respond to Hepatitis C treatment.

rs12979860(C;C) better able to become naturally Hepatitis C virus-free. rs12980275(A) usually corresponds to the rs12979860(C)

GWAS snp
PMID [PMID 19684573]
Trait Response to Hepatitis C treatment
Title Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
Risk Allele C
P-val 1E-28
Odds Ratio 2.00 [1.8-2.3] (European-Americans)
OMIM607402
DescINTERLEUKIN 28B; IL28B
Variant
Relatedalso
[PMID 20176026OA-icon.png] Replicated Association between an IL28B Gene Variant and a Sustained Response to Pegylated Interferon and Ribavirin


[PMID 20235331OA-icon.png] Interferon-lambda genotype and low serum low-density lipoprotein cholesterol levels in patients with chronic hepatitis C infection

[PMID 20389235] Association of a single nucleotide polymorphism near the interleukin-28B gene with response to hepatitis C therapy in HIV/hepatitis C virus-coinfected patients

[PMID 20578254] Interleukin-28B genetic variants and hepatitis virus infection by different viral genotypes

[PMID 20637200] A polymorphism near IL28B is associated with spontaneous clearance, of acute hepatitis C virus and jaundice

[PMID 20964522] Modeling the Probability of Sustained Virological Response to Therapy with Pegylated Interferon plus Ribavirin in Patients Coinfected with Hepatitis C Virus and HIV


[PMID 21068134] HCV substitutions and IL28B polymorphisms on outcome of peg-interferon plus ribavirin combination therapy

[PMID 21070502] Interleukin-28B polymorphisms are associated with hepatitis C virus clearance and viral load in a HIV-1-infected cohort

OMIM609532
Desc
Variant
Relatedalso


[PMID 21413051] Genetic variation in IL28B with respect to vertical transmission of hepatitis C virus and spontaneous clearance in HCV infected children


[PMID 21447862] Association of genetic variation in IL28B with hepatitis C treatment-induced viral clearance in the Chinese Han population


[PMID 21505315] IL28B gene polymorphisms and viral kinetics in HIV/hepatitis C virus-coinfected patients treated with pegylated interferon and ribavirin


[PMID 21618576] Impact of viral amino acid substitutions and host IL28B polymorphism on replication and susceptibility to interferon of hepatitis C virus


[PMID 21647799] Role of Interleukin 28B rs12979860 C/T Polymorphism on the Histological Outcome of Chronic Hepatitis C: Relationship with Gender and Viral Genotype


[PMID 21722179] Predicting response to therapy in chronic hepatitis C: an approach combining IL28B gene polymorphisms and clinical data


[PMID 21750736OA-icon.png] Characterization of Serum Proteins Associated with IL28B Genotype among Patients with Chronic Hepatitis C


[PMID 21790472] IL28B Polymorphism Associated with Spontaneous Clearance of Hepatitis C Infection in a Southern Brazilian HIV Type 1 Population


[PMID 21606533] Interleukin 28B gene variation at rs12979860 determines early viral kinetics during treatment in patients carrying genotypes 2 or 3 of hepatitis C virus


[PMID 21390311OA-icon.png] Response prediction in chronic hepatitis C by assessment of IP-10 and IL28B-related single nucleotide polymorphisms


[PMID 21884517OA-icon.png] IL28B Genotype Does Not Correlate with HIV Control in African Americans


[PMID 21933876OA-icon.png] Genetic Polymorphism in IL28B Is Associated With Spontaneous Clearance of Hepatitis C Virus Genotype 4 Infection in an Egyptian Cohort


[PMID 21987611OA-icon.png] IL28B polymorphisms associated with therapy response in Chilean chronic hepatitis C patients


[PMID 21994136OA-icon.png] Ultra-Rapid Virological Response, Young Age, Low ?-GT/ALT-Ratio, and Absence of Steatosis Identify a Subgroup of HCV Genotype 3 Patients Who Achieve SVR with IFN-?(2a) Monotherapy


[PMID 21760886OA-icon.png] An IL28B genotype-based clinical prediction model for treatment of chronic hepatitis C


[PMID 22087138OA-icon.png] Single nucleotide polymorphisms of the IL28B and sustained virologic response of patients with chronic hepatitis C to PEG-interferon/ribavirin therapy: A meta-analysis: Meta-analysis of IL28B


[PMID 22118055] Single and combined IL28B, ITPA and SLC28A3 host genetic markers modulating response to anti-hepatitis C therapy


[PMID 22234924] Combined effects of different IL28B gene variants on the outcome of dual combination therapy in chronic HCV type 1 infection


[PMID 22239156] IL28B rs12979860 polymorphism dose not influence outcomes of hepatitis B virus infection


[PMID 22257210] A Tetra-Primer Amplification Refractory Mutation System-Polymerase Chain Reaction for the Detection of rs8099917 IL28B Genotype


[PMID 22374338] Evaluation of interleukin 28B single nucleotide polymorphisms in infants suffering from bronchiolitis


[PMID 22473858] IL28B polymorphisms predict interferon-related HBsAg seroclearance in genotype D HBeAg-negative patients with chronic hepatitis B


[PMID 22509814] Frequency of IL28B rs12979860 Single-Nucleotide Polymorphism Alleles in Newborn Infants and in Patients with Chronic Hepatitis C in Morocco


[PMID 22521237] Closed tube method for rapid screening of IL28B polymorphisms involved in response to hepatitis C treatment


[PMID 22530607] Implications of PNPLA3 polymorphism in chronic hepatitis C patients receiving peginterferon plus ribavirin


[PMID 22550527OA-icon.png] Development and Validation of a Simple, Rapid and Inexpensive PCR-RFLP Method for Genotyping of Common IL28B Polymorphisms: A Useful Pharmacogenetic Tool for Prediction of Hepatitis C Treatment Response


[PMID 22108195] Polymorphisms near IL28B and serologic response to peginterferon in HBeAg-positive patients with chronic hepatitis B


[PMID 21889467] Determination of IL28B polymorphisms in liver biopsies obtained after liver transplantation


[PMID 22634340] Association of the IL28B genotype with insulin resistance in patients with chronic hepatitis C


[PMID 22253847OA-icon.png] Sequence analysis of the IL28A/IL28B inverted gene duplication that contains polymorphisms associated with treatment response in hepatitis C patients


[PMID 22253715OA-icon.png] Impact of IL28B-related single nucleotide polymorphisms on liver histopathology in chronic hepatitis C genotype 2 and 3


[PMID 22649509OA-icon.png] IL28B Genetic Variation Is Associated with Spontaneous Clearance of Hepatitis C Virus, Treatment Response, Serum IL-28B Levels in Chinese Population


[PMID 22666430OA-icon.png] Relation of IL28B Gene Polymorphism with Biochemical and Histological Features in Hepatitis C Virus-Induced Liver Disease


[PMID 22664940] Spontaneous clearance of hepatitis C infection after liver transplantation from IL28B rs12979860 CC donors


[PMID 22720022OA-icon.png] A multicentre molecular analysis of hepatitis B and blood-borne virus coinfections in viet nam


[PMID 22790387] Increased Risk of Severe Hepatitis C Virus Recurrence After Liver Transplantation in Patients With a T Allele of IL28B rs12979860

[PMID 19759533OA-icon.png] Genetic variation in IL28B and spontaneous clearance of hepatitis C virus.

[PMID 20399780] Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus.

[PMID 20621700] An IL28B polymorphism determines treatment response of hepatitis C virus genotype 2 or 3 patients who do not achieve a rapid virologic response.

[PMID 20659305] A tetra-primer amplification refractory mutation system polymerase chain reaction for the evaluation of rs12979860 IL28B genotype.

[PMID 20728570] Impact of IL28B genotype on the early and sustained virologic response in treatment-naive patients with chronic hepatitis C.

[PMID 20804372] Prediction of response to pegylated interferon plus ribavirin by IL28B gene variation in patients coinfected with HIV and hepatitis C virus.

[PMID 20889274] IL28B polymorphisms and chronic hepatitis C.

[PMID 20931559OA-icon.png] IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C.

[PMID 20977343OA-icon.png] IL28B polymorphism does not determine outcomes of hepatitis B virus or HIV infection.

[PMID 21080244] The IL-28 genotype: how it will affect the care of patients with hepatitis C virus infection.

[PMID 21112657] Importance of IL28B gene polymorphisms in hepatitis C virus genotype 2 and 3 infected patients.

[PMID 21112660] Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b.

[PMID 21145807] Early virologic response and IL28B polymorphisms in patients with chronic hepatitis C genotype 3 treated with peginterferon alfa-2a and ribavirin.

[PMID 21145813] Interferon-lambda serum levels in hepatitis C.

[PMID 21146242] IL-28B rs12979860 C/T allele distribution in patients with liver cirrhosis: role in the course of chronic viral hepatitis and the development of HCC.

[PMID 21147186] Impact of donor and recipient IL28B rs12979860 genotypes on hepatitis C virus liver graft reinfection.

[PMID 21157362OA-icon.png] Pharmacodynamics of PEG-IFN-[alpha]-2a and HCV response as a function of IL28B polymorphism in HIV/HCV-coinfected patients.

[PMID 21228123] IL-28B predicts response to chronic hepatitis C therapy--fine-mapping and replication study in Asian populations.

[PMID 21254158OA-icon.png] Quantitation of pretreatment serum interferon-gamma-inducible protein-10 improves the predictive value of an IL28B gene polymorphism for hepatitis C treatment response.

[PMID 21254179OA-icon.png] Interleukin-28B polymorphisms are associated with histological recurrence and treatment response following liver transplantation in patients with hepatitis C virus infection.

[PMID 21274371OA-icon.png] Peginterferon and ribavirin treatment for hepatitis C virus infection.

[PMID 21354446] IL28B polymorphisms predict reduction of HCV RNA from the first day of therapy in chronic hepatitis C.

[PMID 21374656] IL28B genetic variation and treatment response in patients with hepatitis C virus genotype 3 infection.

[PMID 21375685] Different distributions of hepatitis C virus genotypes among HIV-infected patients with acute and chronic hepatitis C according to interleukin-28B genotype.

[PMID 21376050OA-icon.png] Coffee consumption is associated with response to peginterferon and ribavirin therapy in patients with chronic hepatitis C.

[PMID 21378537] Association between IL28B gene polymorphisms and plasma HCV-RNA levels in HIV/HCV-co-infected patients.

[PMID 21389156OA-icon.png] The rs8099917 polymorphism, when determined by a suitable genotyping method, is a better predictor for response to pegylated alpha interferon/ribavirin therapy in Japanese patients than other single nucleotide polymorphisms associated with interleukin-28B.

[PMID 21397726] Portal pressure predicts outcome and safety of antiviral therapy in cirrhotic patients with hepatitis C virus infection.

[PMID 21466653] Donor and recipient IL28B polymorphisms in HCV-infected patients undergoing antiviral therapy before and after liver transplantation.

[PMID 21488075] Impact of patatin-like phospholipase-3 (rs738409 C>G) polymorphism on fibrosis progression and steatosis in chronic hepatitis C.

[PMID 21549150] Real-time polymerase chain reaction assay based on high-resolution melting analysis for the determination of the rs12979860 polymorphism involved in hepatitis C treatment response.

[PMID 21572301] Low-density lipoprotein receptor genotyping enhances the predictive value of IL28B genotype in HIV/hepatitis C virus-coinfected patients.

[PMID 21592993] Influence of interleukin-28B single-nucleotide polymorphisms on progression to liver cirrhosis in human immunodeficiency virus-hepatitis C virus-coinfected patients receiving antiretroviral therapy.

[PMID 21600205OA-icon.png] A polymorphism in IL28B distinguishes exposed, uninfected individuals from spontaneous resolvers of HCV infection.

[PMID 21613433OA-icon.png] Interleukin-28B genotyping by melt-mismatch amplification mutation assay PCR analysis using single nucleotide polymorphisms rs12979860 and rs8099917, a useful tool for prediction of therapy response in hepatitis C patients.

[PMID 21626525] Limited use of interleukin 28B in the setting of response-guided treatment with detailed on-treatment virological monitoring.

[PMID 21670772] Importance of host genetic factors HLA and IL28B as predictors of response to pegylated interferon and ribavirin.

[PMID 21692944] IL28B polymorphisms determine early viral kinetics and treatment outcome in patients receiving peginterferon/ribavirin for chronic hepatitis C genotype 1.

[PMID 21703198OA-icon.png] Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C.

[PMID 21703201] The predictive value of IL28B gene polymorphism for spontaneous clearance in a single source outbreak cohort is limited in patients carrying the CCR5Delta32 mutation.

[PMID 21704279OA-icon.png] Simultaneous genotyping of rs12979860 and rs8099917 variants near the IL28B locus associated with HCV clearance and treatment response.

[PMID 21721028] Genetic variation in the interleukin-28B gene is not associated with fibrosis progression in patients with chronic hepatitis C and known date of infection.

[PMID 21726252] IL28B rs12979860 C/T polymorphism in elderly chronic hepatitis C patients treated with pegylated-interferon and ribavirin.

[PMID 21739451] Inverse association of IL28B genotype and liver mRNA expression of genes promoting or suppressing antiviral state.

[PMID 21742841OA-icon.png] IL28B genotype effects during early treatment with peginterferon and ribavirin in difficult-to-treat hepatitis C virus infection.

[PMID 21813376OA-icon.png] Progression of liver fibrosis in HIV/HCV genotype 1 co-infected patients is related to the T allele of the rs12979860 polymorphism of the IL28B gene.

[PMID 21854194] Distribution of polymorphisms in cytochrome P450 2B6, histocompatibility complex P5, chemokine coreceptor 5, and interleukin 28B genes in inhabitants from the central area of Argentina.

[PMID 21889215] IL28B polymorphisms are not associated with the response to interferon-beta in multiple sclerosis.

[PMID 21898478] Association of gene expression involving innate immunity and genetic variation in interleukin 28B with antiviral response.

[PMID 21900787] A single IL28B genotype SNP rs12979860 determination predicts treatment response in patients with chronic hepatitis C Genotype 1 virus.

[PMID 21903134] Interleukin 28B genotype determination using DNA from different sources: A simple and reliable tool for the epidemiological and clinical characterization of hepatitis C.

[PMID 21907615] Polymorphism near the IL28B gene in Korean hepatitis C virus-infected patients treated with peg-interferon plus ribavirin.

[PMID 21911885] Genetic variation in interleukin-28B predicts SVR in hepatitis C genotype 1 Argentine patients treated with PEG IFN and ribavirin.

[PMID 21918436] Host genetics.

[PMID 21932410] Treatment of chronic hepatitis C genotype 1 patients at an academic center in Europe involved in prospective, controlled trials: is there a selection bias?

[PMID 21932415] Interleukin 28B polymorphism predicts pegylated interferon plus ribavirin treatment outcome in chronic hepatitis C genotype 4.

[PMID 21951981] IL28B polymorphism is associated with treatment response in patients with genotype 4 chronic hepatitis C.

[PMID 21971821] Efficacy of chronic hepatitis C therapy with pegylated interferon and ribavirin in patients on methadone maintenance treatment.

[PMID 21974859] Association between IL28B polymorphisms and first-phase viral load decrease in chronic hepatitis C virus-infected patients treated with peginterferon alfa-2b/ribavirin.

[PMID 21983945OA-icon.png] Natural killer inhibitory receptor expression associated with treatment failure and interleukin-28B genotype in patients with chronic hepatitis C.

[PMID 22006276] Impact of IL28B on treatment outcome in hepatitis C virus G1/4 patients receiving response-guided therapy with peginterferon alpha-2a (40KD)/ribavirin.

[PMID 22013224OA-icon.png] IL28B rs12979860 genotype and spontaneous clearance of hepatitis C virus in a multi-ethnic cohort of injection drug users: evidence for a supra-additive association.

[PMID 22027585OA-icon.png] Single nucleotide polymorphism upstream of interleukin 28B associated with phase 1 and phase 2 of early viral kinetics in patients infected with HCV genotype 1.

[PMID 22098416] IL28B polymorphisms are markers of therapy response and are influenced by genetic ancestry in chronic hepatitis C patients from an admixed population.

[PMID 22173157] Prediction of response to pegylated interferon plus ribavirin in HIV/hepatitis C virus (HCV)-coinfected patients using HCV genotype, IL28B variations, and HCV-RNA load.

[PMID 22180419OA-icon.png] IL28B polymorphisms influence stage of fibrosis and spontaneous or interferon-induced viral clearance in thalassemia patients with hepatitis C virus infection.

[PMID 22192885] Serum level of IP-10 increases predictive value of IL28B polymorphisms for spontaneous clearance of acute HCV infection.

[PMID 22212648] Contribution of ribavirin transporter gene polymorphism to treatment response in peginterferon plus ribavirin therapy for HCV genotype 1b patients.

[PMID 22222052] Hepatitis C virus viral kinetics during alpha-2a or alpha-2b pegylated interferon plus ribavirin therapy in liver transplant recipients with different immunosuppression regimes.

[PMID 22234804OA-icon.png] Spontaneous clearance of primary acute hepatitis C virus infection correlated with high initial viral RNA level and rapid HVR1 evolution.

[PMID 22248659] Effect of IL28B genotype on early viral kinetics during interferon-free treatment of patients with chronic hepatitis C.

[PMID 22285807] Hepatic cell-type specific gene expression better predicts HCV treatment outcome than IL28B genotype.

[PMID 22294646OA-icon.png] Impact of IL28B gene polymorphisms on interferon-lambda3 plasma levels during pegylated interferon-alpha/ribavirin therapy for chronic hepatitis C in patients coinfected with HIV.

[PMID 22298465] Early viral load and recipient interleukin-28B rs12979860 genotype are predictors of the progression of hepatitis C after liver transplantation.

[PMID 22300408] Recipient IL28B polymorphism is an important independent predictor of posttransplant diabetes mellitus in liver transplant patients with chronic hepatitis C.

[PMID 22310928] Genetic variation in IL28B is associated with the development of hepatitis B-related hepatocellular carcinoma.

[PMID 22314430] IL28B and PNPLA3 polymorphisms affect histological liver damage in patients with non-alcoholic fatty liver disease.

[PMID 22324878] Does Interleukin-28B Single Nucleotide Polymorphisms Influence the Natural History of Hepatitis B?

[PMID 22329371] IL28B genetic variants and gender are associated with spontaneous clearance of hepatitis C virus infection.

[PMID 22329378] Discordant results using T-ARMS-PCR and sequencing for the evaluation of rs12979860 IL28B genotype.

[PMID 22331604OA-icon.png] Dysregulation of innate immunity in hepatitis C virus genotype 1 IL28B-unfavorable genotype patients: Impaired viral kinetics and therapeutic response.

[PMID 22331649OA-icon.png] HCV RNA levels in a multiethnic cohort of injection drug users: Human genetic, viral and demographic associations.

[PMID 22362153] Differences in virological response to peginterferon-alpha plus ribavirin in HIV-positive patients coinfected with HCV subtypes 1a or 1b.

[PMID 22387386] Predicting sustained viral response to hepatitis C using a rapid and simple IL28B rs8099917 genotyping assay.

[PMID 22411462] Role of IL28B polymorphism in the development of hepatitis C virus-induced hepatocellular carcinoma, graft fibrosis, and posttransplant antiviral therapy.

[PMID 22431022] The interleukin 28B rs12979860 C/T polymorphism and serum cholesterol as predictors of fibrosis progression in patients with chronic hepatitis C and persistently normal transaminases.

[PMID 22438096] Association of two polymorphisms of the IL28B gene with viral factors and treatment response in 1,518 patients infected with hepatitis C virus.

[PMID 22460962] Development of tropical spastic paraparesis in human T-lymphotropic virus type 1 carriers is influenced by interleukin 28B gene polymorphisms.

[PMID 22495472] Recipient interleukin-28B Rs12979860 C/T polymorphism and acute cellular rejection after liver transplantation: role of the calcineurin inhibitor used.

[PMID 22505587] Vitamin D levels and IL28B polymorphisms are related to rapid virological response to standard of care in genotype 1 chronic hepatitis C.

[PMID 22537149] Development of new IL28B genotyping method using Invader Plus assay.

[PMID 22543885OA-icon.png] The association of genetic variants with hepatic steatosis in patients with genotype 1 chronic hepatitis C infection.

[PMID 22545770] IL28B CC Genotype Is Associated with Higher All-Cause Mortality in Antiretroviral-Treated HIV-Infected Patients.

[PMID 22569080OA-icon.png] IL28B favorable genotype and ultrarapid viral response as the earliest treatment predictors of a sustained viral response in a Georgian cohort infected with the hepatitis C genotype 1.

[PMID 22610885] Vitamin D binding protein gene polymorphisms and baseline vitamin D levels as predictors of antiviral response in chronic hepatitis C.

[PMID 22613675] Comparison of three different methods for the evaluation of IL28 and ITPA polymorphisms in patients infected with HCV.

[PMID 22641049] Genetics of IL28B and HCV-response to infection and treatment.

[PMID 22664181] A straightforward genotyping of the relevant IL28B SNPs for the prediction of hepatitis C treatment outcome.


[PMID 22966241OA-icon.png] The impact of interferon lambda 3 gene polymorphism on natural course and treatment of hepatitis C


[PMID 22974940] Measurement and Clinical Significance of Interleukin 28B in Hepatitis C Virus-Infected Liver Transplant Patients


[PMID 22766768] The course of posttransplant hepatitis C infection: comparative impact of donor and recipient source of the favorable IL28B genotype and other variables


[PMID 23032421] Low vitamin D levels are associated with impaired virologic response to PEGIFN+RBV therapy in HIV/HCV coinfected patients


[PMID 23080496OA-icon.png] A single nucleotide polymorphism in IL28B affects viral evolution of hepatitis C quasispecies after pegylated interferon and ribavirin therapy


GET Evidence
rs12979860
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.383929
summary



[PMID 23090351OA-icon.png] Optimum Ribavirin Exposure Overcomes Racial Disparity in Efficacy of Peginterferon and Ribavirin Treatment for Hepatitis C Genotype 1


[PMID 22591106] Meta-analysis: IL28B polymorphisms predict sustained viral response in HCV patients treated with pegylated interferon-α and ribavirin


[PMID 23137758] Genetic polymorphisms of ICAM 1 and IL28 as predictors of liver fibrosis severity and viral clearance in hepatitis C genotype 4


[PMID 23164695] IL28B rs12979860 polymorphism influences serum TNFalpha levels in chronic hepatitis C


[PMID 23173032OA-icon.png] None of the Six SNPs of IL28B Could Predict Treatment Responses in Genotype 2 Chronic HCV Infected Patients by Propensity Score Matching Analysis


[PMID 22719902OA-icon.png] Analysis of IL28B variants in an Egyptian population defines the 20 kilobases minimal region involved in spontaneous clearance of hepatitis C virus


[PMID 23252241] [Immunogenetic predictors of a rapid virologic response to antiviral therapy in patients with chronic hepatitis C]


[PMID 23259930OA-icon.png] Lack of evidence to support the association of a single IL28B genotype SNP rs12979860 with the HTLV-1 clinical outcomes and proviral load


[PMID 23420232OA-icon.png] Genome-Wide Association Study of Spontaneous Resolution of Hepatitis C Virus Infection: Data From Multiple Cohorts


[PMID 23440114OA-icon.png] Response to treatment in Brazilian patients with chronic hepatitis C is associated with a single-nucleotide polymorphism near the interleukin-28B gene


[PMID 23442843] Role of Interleukin 28B-related Gene Polymorphisms in Chronic Hepatitis C and the Response to Antiviral Therapy in Koreans


[PMID 22727259] Different impact of IL28B polymorphisms on response to peginterferon-α plus ribavirin in HIV-positive patients infected with HCV subtypes 1a or 1b


[PMID 23490382] Lack of clinical and histological progression of chronic hepatitis C in individuals with true persistently normal ALT: the result of a 17-year follow-up


[PMID 23029188OA-icon.png] Test of IL28B polymorphisms in chronic hepatitis C patients treated with PegIFN and ribavirin depends on HCV genotypes: results from a meta-analysis


[PMID 23109451] IL28B polymorphisms predict the response to chronic hepatitis C virus infection treatment in a Mexican population


[PMID 23020144] Polymorphisms in interleukin-10 and interleukin-28B genes in Egyptian patients with chronic hepatitis C virus genotype 4 and their effect on the response to pegylated interferon/ribavirin-therapy


[PMID 23712427OA-icon.png] IL28B expression depends on a novel TT/-G polymorphism which improves HCV clearance prediction


[PMID 23784926] Role of IL28B gene polymorphism and cell mediated immunity in spontaneous resolution of acute hepatitis C


[PMID 23782163] Interleukin-28B genetic variations and spontaneous clearance of hepatitis C antibody-positive blood donors in China


[PMID 23835502] The impact of interleukin 28B rs12979860 single nucleotide polymorphism and liver fibrosis stage on response-guided therapy in HIV/HCV-coinfected patients


[PMID 23860735] Genetic variation near interleukin 28B and the risk of hepatocellular carcinoma in patients with chronic hepatitis C


[PMID 23866096] The predictive value of IL28B rs12979860, rs11881222 and rs8099917 polymorphisms and IP-10 in the therapeutic response of Egyptian genotype 4 patients


[PMID 23063570OA-icon.png] IL28B rs12979860 is not associated with histologic features of NAFLD in a cohort of Caucasian North American patients


[PMID 23063569] Reply to: "IL28B rs12979860 is not associated with histologic features of NAFLD in a cohort of Caucasian North American patients"


[PMID 23880623] Single-Nucleotide Polymorphisms of IL-10 and IL-28B as Predictors of the Response of IFN Therapy in HCV Genotype 4-infected Children


[PMID 23939236] Variation in IFNL4 genotype and response to interferon-based therapy of hepatitis C in HIV-positive patients with acute and chronic hepatitis C


[PMID 23231085] IL28B polymorphisms predict response to therapy among chronic hepatitis C patients with HCV genotype 4


[PMID 24072198] IFNL4 ss469415590 variant is a better predictor than ILF3 (IL28B) rs12979860 of pegylated interferon-alpha/ribavirin therapy failure in hepatitis C virus/HIV-1 coinfected patients


[PMID 24085431] Association of the interleukin-28B gene polymorphism with development of hepatitis virus-related hepatocellular carcinoma and liver cirrhosis: a meta-analysis


[PMID 24116050OA-icon.png] A Single Nucleotide Polymorphism Associated with Hepatitis C Virus Infections Located in the Distal Region of the IL28B Promoter Influences NF-κB-Mediated Gene Transcription


[PMID 24131527] A polymorphism linked to RRAS, SCAF1, IRF3 and BCL2L12 genes is associated with cirrhosis in hepatitis C virus carriers


[PMID 24167602OA-icon.png] A Fast and Cost-Effective Method for Identifying a Polymorphism of Interleukin 28B Related to Hepatitis C


[PMID 24224717] Genetic variation in toll-like receptors and retinoic acid-inducible gene I and outcome of hepatitis C virus infection: a candidate gene association study


[PMID 23197895OA-icon.png] Novel biosensor-based microarray assay for detecting rs8099917 and rs12979860 genotypes


[PMID 24293567] Interleukin 28B Gene Polymorphisms in Hepatitis C Virus-related Cryoglobulinemic Vasculitis


[PMID 24367041] IFNL4-ΔG Genotype is Associated with Slower Viral Clearance in Hepatitis C, Genotype-1 Patients Treated with Sofosbuvir and Ribavirin


[PMID 24366548] Expression of selected genes in liver biopsy specimens in relation to early virological response in patients with chronic hepatitis C with HCV mono- and HIV/HCV co-infection


[PMID 24398031OA-icon.png] IL28B and IL10R -1087 polymorphisms are protective for chronic genotype 1 HCV infection and predictors of response to interferon-based therapy in an East-Central European cohort


[PMID 22414761] Apolipoprotein-E and hepatitis C lipoviral particles in genotype 1 infection: evidence for an association with interferon sensitivity.


[PMID 22626609] Factors that predict response of patients with hepatitis C virus infection to boceprevir.


[PMID 22711348] Early anemia and rapid virological response improve the predictive efficiency of IL28B-genotype for treatment outcome to antiviral combination therapy in patients infected with chronic HCV genotype 1.


[PMID 22742526] Meta-analysis: the impact of IL28B polymorphisms on rapid and sustained virological response in HCV-2 and -3 patients.


[PMID 22814458OA-icon.png] Targeting both rs12979860 and rs8099917 polymorphisms with a single-tube high-resolution melting assay for IL28b genotyping.


[PMID 22842190] Interleukin-28B polymorphisms on the SVR in the treatment of naive chronic hepatitis C with pegylated interferon-alpha plus ribavirin: a meta-analysis.


[PMID 22850127] The genotype frequencies of IL28B polymorphisms (rs12979860, rs8099917) among Turkish patients with hepatitis C.


[PMID 22863269] Interleukin-28B (IL-28B) single-nucleotide polymorphisms and interferon plus ribavirin treatment outcome in Italian chronically HCV-infected patients.


[PMID 22913807] Genetic polymorphism of IL28B in hepatitis C-infected haemophilia patients in Israel.


[PMID 22924160] Sustained virologic response and IL28B single-nucleotide polymorphisms in patients with chronic hepatitis C treated with pegylated interferon alfa and ribavirin.


[PMID 22930497OA-icon.png] IL28B polymorphism is not associated with HCV protease diversity in patients co-infected with HIV and HCV treated with pegylated interferon and ribavirin.


[PMID 23002361OA-icon.png] IL28B polymorphism as a predictor of antiviral response in chronic hepatitis C.


[PMID 23011083] Combinations of simple baseline variables accurately predict sustained virological response in patients with recurrent hepatitis C after liver transplantation.


[PMID 23030669] Interleukin 28B rs12979860 (CT/TT) genotype is associated with milder hepatic damage in the natural evolution of HCV/HIV coinfection.


[PMID 23121166] Insulin resistance predicts sustained virological response to treatment of chronic hepatitis C independently of the IL28b rs12979860 polymorphism.


[PMID 23121365] IL28B genetic variation and hepatitis C virus-specific CD4(+) T-cell responses in anti-HCV-positive blood donors.


[PMID 23133602OA-icon.png] Pharmacogenetics of efficacy and safety of HCV treatment in HCV-HIV coinfected patients: significant associations with IL28B and SOCS3 gene variants.


[PMID 23142377] Association study of IL28B: rs12979860 and rs8099917 polymorphisms with SVR in patients infected with chronic HCV genotype 1 to PEG-INF/RBV therapy using systematic meta-analysis.


[PMID 23159283] Importance of IL-10 and IL-6 during chronic hepatitis C genotype-1 treatment and their relation with IL28B.


[PMID 23219017] Cytokines genes polymorphisms in chronic hepatitis C: impact on susceptibility to infection and response to therapy.


[PMID 23220171] Effects of IL28B rs12979860 CC genotype on metabolic profile and sustained virologic response in patients with genotype 1 chronic hepatitis C.


[PMID 23225905] IL28B single-nucleotide polymorphism rs12979860 is associated with spontaneous HIV control in white subjects.


[PMID 23238552] Low vitamin D levels are associated with impaired virologic response to PEGIFN + RBV therapy in HIV-hepatitis C virus coinfected patients.


[PMID 23258530OA-icon.png] Association of gamma-glutamyl transferase (GGT) activity with treatment and clinical outcomes in chronic hepatitis C (HCV).


[PMID 23266640] Interleukin-28B rs12979860C/T and rs8099917T/G contribute to spontaneous clearance of hepatitis C virus in Caucasians.


[PMID 23274935] IL28B polymorphism, pretreatment CXCL10, and HCV RNA levels predict treatment response in racially diverse HIV/HCV coinfected and HCV monoinfected patients.


[PMID 23291588OA-icon.png] A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus.


[PMID 23301546] Role of IL-28B and inosine triphosphatase polymorphisms in efficacy and safety of Peg-Interferon and ribavirin in chronic hepatitis C compensated cirrhosis with and without oesophageal varices.


[PMID 23301835] IL28B genotype is not useful for predicting treatment outcome in Asian chronic hepatitis B patients treated with pegylated interferon-alpha.


[PMID 23314745OA-icon.png] Impact of IL-28B polymorphisms on pegylated interferon plus ribavirin treatment response in children and adolescents infected with HCV genotypes 1 and 4.


[PMID 23333445OA-icon.png] Differential effects of donor and recipient IL28B and DDX58 SNPs on severity of HCV after liver transplantation.


[PMID 23396730] Vitamin D deficiency and vitamin D therapy in chronic hepatitis C.


[PMID 23439262] A phase 2a trial of 12-week interferon-free therapy with two direct-acting antivirals (ABT-450/r, ABT-072) and ribavirin in IL28B C/C patients with chronic hepatitis C genotype 1.


[PMID 23449268] HLA-DP and IL28B polymorphisms: influence of host genome on hepatitis B surface antigen seroclearance in chronic hepatitis B.


[PMID 23455512OA-icon.png] IL28B SNP screening and distribution in the French Canadian population using a rapid PCR-based test.


[PMID 23490377] Value of IL28B genotyping in patients with HCV-related mixed cryoglobulinemia: results of a large, prospective study.


[PMID 23499727] Natural killer cell dynamic profile is associated with treatment outcome in patients with chronic HCV infection.


[PMID 23564545] Interferon-lambda polymorphisms and hepatitis C virus clearance revisited.


[PMID 23587473] Treatment optimization and prediction of HCV clearance in patients with acute HCV infection.


[PMID 23611115] Impact of interleukin 28B polymorphisms on spontaneous clearance of hepatitis C virus infection: a meta-analysis.


[PMID 23611467] CARD8 gene encoding a protein of innate immunity is expressed in human atherosclerosis and associated with markers of inflammation.


[PMID 23715768] Effects of the genetic pattern defined by low-density lipoprotein receptor and IL28B genotypes on the outcome of hepatitis C virus infection.


[PMID 24776764] The association of il28b genotype with the histological features of chronic hepatitis C is HCV genotype dependent


[PMID 24379268] [The role of hepcidin and polymorphisms in the regulatory region of the IL-28B gene in HCV infections]


[PMID 24914551] Impact of Host IL28B rs12979860, rs8099917 in Interferon Responsiveness and Advanced Liver Disease in Chronic Genotype 3 Hepatitis C Patients


[PMID 24927414] Diversity of Killer Cell Immunoglobulin-Like Receptor (KIR) Genotypes and KIR2DL2/3 Variants in HCV Treatment Outcome


[PMID 24379617] Interleukin 28B polymorphisms as predictor of response in hepatitis C virus genotype 2 and 3 infected patients


[PMID 24999753] Interleukin 28B Polymorphisms and Therapy Response in Egyptian Hepatitis C Genotype-4 Patients


[PMID 25004625] The importance of sCD40 and sCD40L concentration in patients with chronic HCV infection and HIV co-infection


[PMID 25032184] No association between the IL28B SNP and response to peginterferon plus ribavirin combination treatment in Korean chronic hepatitis C patients


[PMID 24204859] Association of IFNL3 rs12979860 and rs8099917 with biochemical predictors of interferon responsiveness in chronic hepatitis C virus infection


[PMID 25204264] Not so sweet: autoimmune diabetes mellitus on triple therapy for chronic hepatitis C infection


[PMID 25227816] IL28B rs12979860 Gene Polymorphism in Egyptian Patients with Chronic Liver Disease Infected with HCV


[PMID 25233462] IL28B Gene Polymorphism SNP rs8099917 Genotype GG Is Associated with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) in HTLV-1 Carriers