rs12980275

Orientation

plus

Stabilized

plus

Make rs12980275(A;A)

Make rs12980275(A;G)

Make rs12980275(G;G)

Reference

GRCh38 38.1/141

Chromosome

19

Position

39241143

is a	snp
is	mentioned by
dbSNP	rs12980275
dbSNP (classic)	rs12980275
ClinGen	rs12980275
ebi	rs12980275
HLI	rs12980275
Exac	rs12980275
Gnomad	rs12980275
Varsome	rs12980275
LitVar	rs12980275
Map	rs12980275
PheGenI	rs12980275
Biobank	rs12980275
1000 genomes	rs12980275
hgdp	rs12980275
ensembl	rs12980275
geneview	rs12980275
scholar	rs12980275
google	rs12980275
pharmgkb	rs12980275
gwascentral	rs12980275
openSNP	rs12980275
23andMe	rs12980275
SNPshot	rs12980275
SNPdbe	rs12980275
MSV3d	rs12980275
GWAS Ctlg	rs12980275

GMAF

0.314

Max Magnitude

0

?	(A;A) (A;G) (G;G)	28

23andMe blog

rs8099917(C) less likely to respond to Hepatitis C treatment.

rs12979860(C;C) better able to become naturally Hepatitis C virus-free. rs12980275(A) usually corresponds to the rs12979860(C)

[PMID 19749757] Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C

OMIM	607402
Desc	INTERLEUKIN 28B; IL28B
Variant
Related	also

OMIM	609532
Desc
Variant
Related	also

[PMID 21390311] Response prediction in chronic hepatitis C by assessment of IP-10 and IL28B-related single nucleotide polymorphisms

[PMID 21987611] IL28B polymorphisms associated with therapy response in Chilean chronic hepatitis C patients

[PMID 22118055] Single and combined IL28B, ITPA and SLC28A3 host genetic markers modulating response to anti-hepatitis C therapy

[PMID 22234924] Combined effects of different IL28B gene variants on the outcome of dual combination therapy in chronic HCV type 1 infection

[PMID 22253715] Impact of IL28B-Related Single Nucleotide Polymorphisms on Liver Histopathology in Chronic Hepatitis C Genotype 2 and 3

[PMID 22108195] Polymorphisms near IL28B and serologic response to peginterferon in HBeAg-positive patients with chronic hepatitis B

[PMID 22649509] IL28B Genetic Variation Is Associated with Spontaneous Clearance of Hepatitis C Virus, Treatment Response, Serum IL-28B Levels in Chinese Population

[PMID 22329371] IL28B genetic variants and gender are associated with spontaneous clearance of hepatitis C virus infection

GWAS snp
PMID	[PMID 22497812]
Trait
Title	Interleukin 28B polymorphisms are the only common genetic variants associated with low-density lipoprotein cholesterol (LDL-C) in genotype-1 chronic hepatitis C and determine the association between LDL-C and treatment response.
Risk Allele
P-val	5E-17
Odds Ratio	None None

[PMID 20708617] Variants in IL28B in liver recipients and donors correlate with response to peg-interferon and ribavirin therapy for recurrent hepatitis C.

[PMID 21112657] Importance of IL28B gene polymorphisms in hepatitis C virus genotype 2 and 3 infected patients.

[PMID 21112660] Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b.

[PMID 21274371] Peginterferon and ribavirin treatment for hepatitis C virus infection.

[PMID 21354446] IL28B polymorphisms predict reduction of HCV RNA from the first day of therapy in chronic hepatitis C.

[PMID 21443535] IL28B polymorphisms, IP-10 and viral load predict virological response to therapy in chronic hepatitis C.

[PMID 22310928] Genetic variation in IL28B is associated with the development of hepatitis B-related hepatocellular carcinoma.

[PMID 23103287] IL28B polymorphisms are associated with severity of liver disease in human immunodeficiency virus (HIV) patients coinfected with hepatitis C virus.

[PMID 23135173] Analysis of IL28B alleles with virologic response patterns and plasma cytokine levels in HIV/HCV-coinfected patients.

[PMID 23314745] Impact of IL-28B polymorphisms on pegylated interferon plus ribavirin treatment response in children and adolescents infected with HCV genotypes 1 and 4.

[PMID 23565619] IL28RA polymorphism is associated with early hepatitis C virus (HCV) treatment failure in human immunodeficiency virus-/HCV-coinfected patients.

[PMID 24999753] Interleukin 28B Polymorphisms and Therapy Response in Egyptian Hepatitis C Genotype-4 Patients

[PMID 25032184] No association between the IL28B SNP and response to peginterferon plus ribavirin combination treatment in Korean chronic hepatitis C patients

[PMID 25652367] IL28B rs12980275 polymorphism shows association with response to treatment in Pakistani patients with Chronic Hepatitis C

[PMID 25769643] IL28B rs12980275 variant as a predictor of sustained virologic response to pegylated-interferon and ribavirin in chronic hepatitis C patients: A systematic review and meta-analysis

[PMID 24118788] Genetic variation in interleukin 28B and correlation with chronic hepatitis B virus infection in Saudi Arabian patients

[PMID 24924923] The relationship between IL-28B polymorphisms and the response to peginterferon alfa-2a monotherapy in anti-HBe-positive patients with chronic HBV infection

[PMID 25938745] IL28B polymorphisms of both recipient and donor cooperate to influence IFN treatment response in HCV recurrence after liver transplantation, but IL28B SNPs of the recipient play a major role in IFN-induced blocking of HCV replication

[PMID 25663241] Genetic Variants in Interleukin-28B Are Associated with Diabetes and Diabetes-Related Complications in Patients with Chronic Hepatitis C Virus Infection

[PMID 25661337] Role of pharmacogenetic in ribavirin outcome prediction and pharmacokinetics in an Italian cohort of HCV-1 and 4 patients

[PMID 24840315] Interleukin-28 gene polymorphisms may contribute to HBsAg persistence and the development of HBeAg-negative chronic hepatitis B

[PMID 26740868] Prevalence of Hepatitis C among Egyptian Children with Sickle Cell Disease and the Role of IL28b Gene Polymorphisms in Spontaneous Viral Clearance.

[PMID 32058988] IL-28B genotypes as predictors of long-term outcome in patients with hepatitis C-related severe liver injury.

[PMID 32478085] IFNL3 rs12980275 Polymorphism Predicts Septic Shock-Related Death in Patients Undergoing Major Surgery: A Retrospective Study.