Rs12593813

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is asnp
is mentioned by
dbSNPrs12593813
hapmaprs12593813
hgdprs12593813
ensemblrs12593813
gopubmedrs12593813
scholarrs12593813
googlers12593813
pharmgkbrs12593813
hgvbaseg2prs12593813
medrefsnprs12593813
23andMers12593813
SNP Nexus

GeneMAP2K5
Chromosome15
Orientationplus
Position65823905
GenotypeEffect
rs12593813(A;A)<0.71x risk for restless legs
rs12593813(A;G)0.71x risk for restless legs
rs12593813(G;G)common


Genotypes Magnitude Summary
Rs12593813(A;A) <0.71x risk for restless legs
Rs12593813(A;G) 0.71x risk for restless legs
Rs12593813(C;C) 00
Rs12593813(G;G) 00 common
rs12593813, a SNP located in a region of chromosome 15q, has been linked to a lower frequency of restless legs syndrome, a common sleep disorder, with an overall odds ratio of 0.71 (CI: 0.60-0.83) for the (A) minor allele. [PMID 17637780]
Neighborrs11635424
Distance726
? (A;A) (A;G) (G;G)
GWAS
SNP rs12593813
PubMedID [PMID 17637780]
Condition Restless legs syndrome
Gene MAP2K5, LBXCOR1
Risk Allele G
pValue 1.00E-015
OR 1.5
95% CI 1.36-1.66


[PMID 19223043] Exploring the genetic link between RLS and ADHD

PharmGKBPA162355629
Name
AnnotationIn replicated GWAS case-control studies of Caucasian(European and French-Canadian) familial and sporadic RLS, the G allele of rs12593813 was significantly associated with Restless Legs Syndrome.
GeneMAP2K5
Featue
EvidencePubMed ID:17637780
Drugs
DiseasesRestless Legs Syndrome
Curation LevelCurated
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