rs11805303
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | normal |
| (C;T) | 1.4x risk of Crohn's disease | |
| (T;T) | 1.8x risk of Crohn's disease |
| Reference | GRCh38 38.1/141 |
| Chromosome | 1 |
| Position | 67209833 |
| Gene | IL23R |
| is a | snp |
| is | mentioned by |
| dbSNP | rs11805303 |
| dbSNP (classic) | rs11805303 |
| ClinGen | rs11805303 |
| ebi | rs11805303 |
| HLI | rs11805303 |
| Exac | rs11805303 |
| Gnomad | rs11805303 |
| Varsome | rs11805303 |
| LitVar | rs11805303 |
| Map | rs11805303 |
| PheGenI | rs11805303 |
| Biobank | rs11805303 |
| 1000 genomes | rs11805303 |
| hgdp | rs11805303 |
| ensembl | rs11805303 |
| geneview | rs11805303 |
| scholar | rs11805303 |
| rs11805303 | |
| pharmgkb | rs11805303 |
| gwascentral | rs11805303 |
| openSNP | rs11805303 |
| 23andMe | rs11805303 |
| SNPshot | rs11805303 |
| SNPdbe | rs11805303 |
| MSV3d | rs11805303 |
| GWAS Ctlg | rs11805303 |
| GMAF | 0.3333 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs11805303 has been reported in a large study to be associated with Crohn's disease.
The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 1.39 (CI 1.22-1.58), and for homozygotes, 1.86 (CI 1.54-2.24). [PMID 17554300
]
[PMID 18438406] Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
[PMID 18533027] Worldwide population differentiation at disease-associated SNPs.
[PMID 19249008] Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease.
[PMID 19522770] Variants of the IL23R gene are associated with ankylosing spondylitis but not with Sjogren syndrome in Hungarian population samples.
[PMID 19757086] Interleukin-23 receptor gene variants in Hungarian systemic lupus erythematosus patients.
[PMID 19918037] Association of interleukin 23 receptor polymorphisms with anti-topoisomerase-I positivity and pulmonary hypertension in systemic sclerosis.
[PMID 20978829] Polymorphisms of the IL23R gene are associated with psoriasis but not with immunoglobulin A nephropathy in a Hungarian population.
[PMID 22426692] Confirmation of three inflammatory bowel disease susceptibility loci in a Chinese cohort.
[PMID 23093364] Difference of interleukin-23 receptor gene haplotype variants in ulcerative colitis compared to Crohn's disease and psoriasis
