Rs11635424

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is asnp
is mentioned by
dbSNPrs11635424
hapmaprs11635424
hgdprs11635424
ensemblrs11635424
gopubmedrs11635424
scholarrs11635424
googlers11635424
pharmgkbrs11635424
hgvbaseg2prs11635424
medrefsnprs11635424
23andMers11635424
SNP Nexus

GeneMAP2K5
Chromosome15
Orientationplus
Position65824631
GenotypeEffect
rs11635424(A;A)<0.70x risk for restless legs
rs11635424(A;G)0.70x risk for restless legs
rs11635424(G;G)common


Genotypes Magnitude Summary
Rs11635424(A;A) <0.70x risk for restless legs
Rs11635424(A;G) 0.70x risk for restless legs
Rs11635424(C;C) 00
Rs11635424(G;G) 00 common
rs11635424, a SNP located in a region of chromosome 15q, has been linked to a lower frequency of restless legs syndrome, a common sleep disorder, with an overall odds ratio of 0.70 (CI: 0.59-0.82) for the (A) minor allele. [PMID 17637780]
Neighborrs12593813
Distance726
? (A;A) (A;G) (G;G)
PharmGKBPA162355630
Name
AnnotationIn replicated GWAS case-control studies of Caucasian(European and French-Canadian) familial and sporadic RLS, the G allele of rs11635424 was significantly associated with Restless Legs Syndrome.
GeneMAP2K5
Featue
EvidencePubMed ID:17637780
Drugs
DiseasesRestless Legs Syndrome
Curation LevelCurated