23andMe blog rs10994336 or (rs4948418) Each T at this SNP increased the odds of developing bipolar disorder by 1.45 times compared to the CC genotype.
[PMID 19416921] Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry
[PMID 20636642] Evidence for cis-acting regulation of ANK3 and CACNA1C gene expression
[PMID 21676128] The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy males
[PMID 19088739] Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder.
[PMID 21304963] The cognitive impact of the ANK3 risk variant for bipolar disorder: initial evidence of selectivity to signal detection during sustained attention.
[PMID 21395576] No association between bipolar disorder risk polymorphisms in ANK3 and CACNA1C and common migraine.
[PMID 21438140] Association of ANK3 with bipolar disorder confirmed in East Asia.
[PMID 21767209] ANK3, CACNA1C and ZNF804A gene variants in bipolar disorders and psychosis subphenotype.
[PMID 21972176] Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples.
[PMID 22079454] Genome-wide supported risk variant for bipolar disorder alters anatomical connectivity in the human brain.
|qualified_impact||Insufficiently evaluated pathogenic|
[PMID 23109352] ANK3 as a risk gene for schizophrenia: New data in han Chinese and meta analysis