23andMe blog rs10994336 or (rs4948418) Each T at this SNP increased the odds of developing bipolar disorder by 1.45 times compared to the CC genotype.
This is one of the SNPs reported by NutraHacker.
[PMID 19416921] Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry
[PMID 20636642] Evidence for cis-acting regulation of ANK3 and CACNA1C gene expression
[PMID 21676128] The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy males
[PMID 19088739] Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder.
[PMID 21304963] The cognitive impact of the ANK3 risk variant for bipolar disorder: initial evidence of selectivity to signal detection during sustained attention.
[PMID 21395576] No association between bipolar disorder risk polymorphisms in ANK3 and CACNA1C and common migraine.
[PMID 21438140] Association of ANK3 with bipolar disorder confirmed in East Asia.
[PMID 21767209] ANK3, CACNA1C and ZNF804A gene variants in bipolar disorders and psychosis subphenotype.
[PMID 21972176] Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples.
[PMID 22079454] Genome-wide supported risk variant for bipolar disorder alters anatomical connectivity in the human brain.
|qualified_impact||Insufficiently evaluated pathogenic|
[PMID 23109352] ANK3 as a risk gene for schizophrenia: New data in han Chinese and meta analysis
[PMID 24016415] Association of a risk allele of ANK3 with cognitive performance and cortical thickness in patients with first-episode psychosis
[PMID 24108394] Independent Modulation of Engagement and Connectivity of the Facial Network During Affect Processing by CACNA1C and ANK3 Risk Genes for Bipolar Disorder
[PMID 24361380] Genetic modulation of working memory deficits by ankyrin 3 gene in schizophrenia
[PMID 22005930] Genome-wide association study of Alzheimer's disease with psychotic symptoms.
[PMID 22498896] Bipolar disorder ANK3 risk variant effect on sustained attention is replicated in a large healthy population.
[PMID 23070075] Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample.
[PMID 24914473] Genetic association of LMAN2L gene in schizophrenia and bipolar disorder and its interaction with ANK3 gene polymorphism