Rs10994336

Orientation

plus

is a	snp
is	mentioned by
dbSNP	rs10994336
PheGenI	rs10994336
nextbio	rs10994336
hapmap	rs10994336
1000 genomes	rs10994336
hgdp	rs10994336
ensembl	rs10994336
gopubmed	rs10994336
geneview	rs10994336
scholar	rs10994336
google	rs10994336
pharmgkb	rs10994336
gwascentral	rs10994336
openSNP	rs10994336
23andMe	rs10994336
23andMe all	rs10994336
SNP Nexus
SNPshot	rs10994336
SNPdbe	rs10994336
MSV3d	rs10994336

Gene

ANK3

Chromosome

10

Orientation

plus

GMAF

0.1319

Position

62179812

Reference

GRCh37.p5 37.3/135

Max Magnitude

0

Geno	Mag	Summary
(C;C)	0	common on affy axiom data

Make rs10994336(C;T)

Make rs10994336(T;T)

?	(C;C) (C;T) (T;T)	28

23andMe blog rs10994336 or (rs4948418) Each T at this SNP increased the odds of developing bipolar disorder by 1.45 times compared to the CC genotype.

GWAS
SNP	rs10994336
PubMedID	[PMID 18711365]
Condition	Bipolar disorder
Gene	ANK3
Risk Allele	T
pValue	9.00E-009
OR	1.45
95% CI

[PMID 19416921] Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry

OMIM	125480
Desc	MAJOR AFFECTIVE DISORDER 1; MAFD1
Variant
Related	also

OMIM	612357
Desc	MAJOR AFFECTIVE DISORDER 8; MAFD8
Variant
Related	also

[PMID 20636642] Evidence for cis-acting regulation of ANK3 and CACNA1C gene expression

[PMID 21676128] The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy males

[PMID 19088739] Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder.

[PMID 21304963] The cognitive impact of the ANK3 risk variant for bipolar disorder: initial evidence of selectivity to signal detection during sustained attention.

[PMID 21395576] No association between bipolar disorder risk polymorphisms in ANK3 and CACNA1C and common migraine.

[PMID 21438140] Association of ANK3 with bipolar disorder confirmed in East Asia.

[PMID 21767209] ANK3, CACNA1C and ZNF804A gene variants in bipolar disorders and psychosis subphenotype.

[PMID 21972176] Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples.

[PMID 22079454] Genome-wide supported risk variant for bipolar disorder alters anatomical connectivity in the human brain.

GET Evidence
rs10994336
aa_change
aa_change_short
impact	pathogenic
qualified_impact	Insufficiently evaluated pathogenic
overall_frequency	0.09375
summary

[PMID 23109352] ANK3 as a risk gene for schizophrenia: New data in han Chinese and meta analysis