Rs10994336

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Geno Mag Summary
(C;C) 0 common on affy axiom data
(C;T) 2 1.45x increased odds of developing bipolar disorder
(T;T) 2 2.9x increased odds of developing bipolar disorder
ReferenceGRCh37.p5 37.3/135
Chromosome10
Position62179812
GeneANK3
is asnp
is mentioned by
dbSNPrs10994336
Exacrs10994336
PheGenIrs10994336
nextbiors10994336
hapmaprs10994336
1000 genomesrs10994336
hgdprs10994336
ensemblrs10994336
gopubmedrs10994336
geneviewrs10994336
scholarrs10994336
googlers10994336
pharmgkbrs10994336
gwascentralrs10994336
openSNPrs10994336
23andMers10994336
23andMe allrs10994336
SNP Nexus

SNPshotrs10994336
SNPdbers10994336
MSV3drs10994336
GMAF0.1318
Max Magnitude2
? (C;C) (C;T) (T;T) 28
23andMe blog rs10994336 or (rs4948418) Each T at this SNP increased the odds of developing bipolar disorder by 1.45 times compared to the CC genotype.
GWAS
SNP rs10994336
PubMedID [PMID 18711365OA-icon.png]
Condition Bipolar disorder
Gene ANK3
Risk Allele T
pValue 9.00E-009
OR 1.45
95% CI


This is one of the SNPs reported by NutraHacker.


[PMID 19416921OA-icon.png] Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry

OMIM125480
DescMAJOR AFFECTIVE DISORDER 1; MAFD1
Variant
Relatedalso
OMIM612357
DescMAJOR AFFECTIVE DISORDER 8; MAFD8
Variant
Relatedalso



[PMID 20636642] Evidence for cis-acting regulation of ANK3 and CACNA1C gene expression



[PMID 21676128] The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy males


[PMID 19088739OA-icon.png] Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder.


[PMID 21304963OA-icon.png] The cognitive impact of the ANK3 risk variant for bipolar disorder: initial evidence of selectivity to signal detection during sustained attention.


[PMID 21395576] No association between bipolar disorder risk polymorphisms in ANK3 and CACNA1C and common migraine.


[PMID 21438140] Association of ANK3 with bipolar disorder confirmed in East Asia.


[PMID 21767209] ANK3, CACNA1C and ZNF804A gene variants in bipolar disorders and psychosis subphenotype.


[PMID 21972176] Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples.


[PMID 22079454] Genome-wide supported risk variant for bipolar disorder alters anatomical connectivity in the human brain.


GET Evidence
rs10994336
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.09375
summary



[PMID 23109352] ANK3 as a risk gene for schizophrenia: New data in han Chinese and meta analysis


[PMID 24016415OA-icon.png] Association of a risk allele of ANK3 with cognitive performance and cortical thickness in patients with first-episode psychosis


[PMID 24108394] Independent Modulation of Engagement and Connectivity of the Facial Network During Affect Processing by CACNA1C and ANK3 Risk Genes for Bipolar Disorder


[PMID 24361380] Genetic modulation of working memory deficits by ankyrin 3 gene in schizophrenia


[PMID 22005930OA-icon.png] Genome-wide association study of Alzheimer's disease with psychotic symptoms.


[PMID 22498896] Bipolar disorder ANK3 risk variant effect on sustained attention is replicated in a large healthy population.


[PMID 23070075OA-icon.png] Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample.


[PMID 24914473] Genetic association of LMAN2L gene in schizophrenia and bipolar disorder and its interaction with ANK3 gene polymorphism