From SNPedia
rs10918594, a SNP in the NOS1AP gene encoding the nitric oxide synthase I protein, accounts for some of the variation seen in abnormal heart rhythms, in particular, the QT interval. Based on studies totaling ~4,000 individuals of Caucasian ancestry, homozygotes for one allele have shorter QT intervals, while homozygotes for the other allele have a longer QT interval. [PMID 16648850]
A follow-up study determined that one rs10918594(G) allele was associated with a 3.6-ms (CI: 2.7 - 4.4ms, p=6.9x10(-17)) increase in QT interval duration, and two (G) alleles had twice that increase. No increase in risk for sudden death due to a cardiac problem was associated with this SNP, though. [PMID 17576865]
[PMID 18235038] rs10494366 minor homozygotes had a 9.3 msec longer QT interval compared to major homozygotes (p=5.7x10(-5)); rs10918594 minor homozygotes had a 12.5 msec longer QT interval compared to major homozygotes (p=1.5x10(-6)). Restricting analyses to the diabetic EAs strengthened the effect despite the reduction in sample size (11.3 msec difference, p=5.1x10(-5); 13.9 msec difference, p=1.6x10(-6), respectively).
[PMID 19247217] Calcium channel blockers, NOS1AP, and heart-rate-corrected QT prolongation
| PharmGKB | PA163993333 |
| Name | |
| Annotation | In a study of 112 patients taking verapamil, patients with genotype GG of this SNP showed significantly more QTc prolongation than users with the CC genotype. Genotype at this SNP was not significantly associated with QTc prolongation in the 44 patients studied who were taking isradipine. |
| Gene | NOS1AP |
| Featue | |
| Evidence | PubMed ID:19247217 |
| Drugs | isradipine, verapamil |
| Diseases | |
| Curation Level | Curated |
[PMID 20215044] Relationship of Common Candidate Gene Variants to Electrocardiographic T-Wave Peak to T-Wave End Interval and T-Wave Morphology Parameters
