Rs10883866

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ReferenceGRCh37 37.1/131
Chromosome10
Position83643639
GeneNRG3
is asnp
is mentioned by
dbSNPrs10883866
Exacrs10883866
PheGenIrs10883866
nextbiors10883866
hapmaprs10883866
1000 genomesrs10883866
hgdprs10883866
ensemblrs10883866
gopubmedrs10883866
geneviewrs10883866
scholarrs10883866
googlers10883866
pharmgkbrs10883866
gwascentralrs10883866
openSNPrs10883866
23andMers10883866
23andMe allrs10883866
SNP Nexus

SNPshotrs10883866
SNPdbers10883866
MSV3drs10883866
GMAF0.1079
Max Magnitude
? (C;C) (C;G) (G;G) 28
rs10883866 is a SNP in the neuregulin 3 NRG3 gene.

Based on a study of 1515 Ashkenazi Jewish individuals, including 285 parent-child trios, 173 unrelated cases, and 487 unrelated controls, three SNPs (rs10883866, rs10748842, and rs6584400) were found to be associated with the "delusion" factor as a quantitative trait in schizophrenia, even though no SNP in this study withstood multiple test correction for association with the binary schizophrenia phenotype itself. After replication in an independent set of 153 Ashkenazi Jewish samples, the empirical study-wide significance across all 9 factors studied was estimated to be p = 2.7x10e-3.[PMID 19118813OA-icon.png]

OMIM608078
DescSCHIZOPHRENIA 11
Variant
Relatedalso
[PMID 20713722OA-icon.png] Common genetic variation in Neuregulin 3 (NRG3) influences risk for schizophrenia and impacts NRG3 expression in human brain


[PMID 20548296] Neuregulin 3 (NRG3) as a susceptibility gene in a schizophrenia subtype with florid delusions and relatively spared cognition.


GET Evidence
rs10883866
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.148438
summary