Rs10748842

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Orientationplus
is asnp
is mentioned by
dbSNPrs10748842
PheGenIrs10748842
nextbiors10748842
hapmaprs10748842
1000 genomesrs10748842
hgdprs10748842
ensemblrs10748842
gopubmedrs10748842
geneviewrs10748842
scholarrs10748842
googlers10748842
pharmgkbrs10748842
gwascentralrs10748842
openSNPrs10748842
23andMers10748842
23andMe allrs10748842
SNP Nexus

SNPshotrs10748842
SNPdbers10748842
MSV3drs10748842
GeneNRG3
Chromosome10
Orientationplus
GMAF0.1084
Position83649739
ReferenceGRCh37 37.1/131
Max Magnitude
Make rs10748842(C;C)
Make rs10748842(C;T)
Make rs10748842(T;T)
? (C;C) (C;T) (T;T) 28
rs10748842 is a SNP in the neuregulin 3 NRG3 gene.

Based on a study of 1515 Ashkenazi Jewish individuals, including 285 parent-child trios, 173 unrelated cases, and 487 unrelated controls, three SNPs (rs10883866, rs10748842, and rs6584400) were found to be associated with the "delusion" factor as a quantitative trait in schizophrenia, even though no SNP in this study withstood multiple test correction for association with the binary schizophrenia phenotype itself. After replication in an independent set of 153 Ashkenazi Jewish samples, the empirical study-wide significance across all 9 factors studied was estimated to be p = 2.7x10e-3.[PMID 19118813OA-icon.png]



[PMID 20713722OA-icon.png] Common genetic variation in Neuregulin 3 (NRG3) influences risk for schizophrenia and impacts NRG3 expression in human brain

OMIM605533
DescNEUREGULIN 3; NRG3
Variant
Relatedalso


GET Evidence
rs10748842
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.15625
summary