Rs10505477
| Orientation | minus |
| is a | snp |
| is | mentioned by |
| dbSNP | rs10505477 |
| PheGenI | rs10505477 |
| nextbio | rs10505477 |
| hapmap | rs10505477 |
| 1000 genomes | rs10505477 |
| hgdp | rs10505477 |
| ensembl | rs10505477 |
| gopubmed | rs10505477 |
| geneview | rs10505477 |
| scholar | rs10505477 |
| rs10505477 | |
| pharmgkb | rs10505477 |
| gwascentral | rs10505477 |
| openSNP | rs10505477 |
| 23andMe | rs10505477 |
| 23andMe all | rs10505477 |
| SNP Nexus | |
| SNPshot | rs10505477 |
| SNPdbe | rs10505477 |
| MSV3d | rs10505477 |
| Chromosome | 8 |
| Orientation | minus |
| GMAF | 0.4606 |
| Position | 128407443 |
| Reference | GRCh37 37.1/131 |
| Max Magnitude |
| Make rs10505477(C;C) |
| Make rs10505477(C;T) |
| Make rs10505477(T;T) |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
[PMID 18839428] colorectal cancer rs10505477 and rs6983267 yielded allelic p-values of 1.42 x 10(-7) and 2.57 x 10(-7), respectively with OR=1.50 (95% CI: 1.29-1.75). Risk region was delineated by SNPs rs10505477 and rs7014346 and comprised 17 kb
| GWAS | |
|---|---|
| SNP | rs10505477 |
| PubMedID | [PMID 17618283] |
| Condition | Colorectal cancer |
| Gene | ORF DQ515897 |
| Risk Allele | A |
| pValue | 3.00E-011 |
| OR | 1.17 |
| 95% CI | 1.12-1.23 |
[PMID 21102338] Possible association between a genetic polymorphism at 8q24 and risk of upper gastrointestinal cancer
[PMID 21129217] Characterization of the association between 8q24 and colon cancer: gene-environment exploration and meta-analysis
[PMID 21722176] Association of 8q24.21 locus with the risk of colorectal cancer: A systematic review and meta-analysis
[PMID 22505654] GWAS-identified colorectal cancer susceptibility loci associated with clinical outcomes
[PMID 17630503] Genetic variation in 8q24 associated with risk of colorectal cancer.
[PMID 18372901] Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.
[PMID 18535017] Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk.
[PMID 18577746] Multiple loci with different cancer specificities within the 8q24 gene desert.
[PMID 18670647] Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer.
[PMID 18973230] Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations.
[PMID 19155440] Meta association of colorectal cancer confirms risk alleles at 8q24 and 18q21.
[PMID 19520795] Novel single nucleotide polymorphism associations with colorectal cancer on chromosome 8q24 in African and European Americans.
[PMID 20158306] Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer.
[PMID 20437058] The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer.
[PMID 21455501] Genetic variants on chromosome 8q24 and colorectal neoplasia risk: a case-control study in China and a meta-analysis of the published literature.
| GET Evidence | |
|---|---|
| rs10505477 | |
| aa_change | |
| aa_change_short | |
| impact | pathogenic |
| qualified_impact | Insufficiently evaluated pathogenic |
| overall_frequency | 0.46875 |
| summary | |
[PMID 23677573] Genome-wide association study identifies possible genetic risk factors for colorectal adenomas
