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Rs10505477

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Orientationminus
is asnp
is mentioned by
dbSNPrs10505477
PheGenIrs10505477
nextbiors10505477
hapmaprs10505477
1000 genomesrs10505477
hgdprs10505477
ensemblrs10505477
gopubmedrs10505477
geneviewrs10505477
scholarrs10505477
googlers10505477
pharmgkbrs10505477
gwascentralrs10505477
openSNPrs10505477
23andMers10505477
23andMe allrs10505477
SNP Nexus

SNPshotrs10505477
SNPdbers10505477
MSV3drs10505477
GeneLOC101930033
Chromosome8
Orientationminus
GMAF0.461
Position127395198
ReferenceGRCh38 38.1/141
Max Magnitude
Make rs10505477(C;C)
Make rs10505477(C;T)
Make rs10505477(T;T)
? (C;C) (C;T) (T;T) 28
[PMID 18056436] Associated with risk of colorectal cancer; (P = 0.005)

[PMID 18839428] colorectal cancer rs10505477 and rs6983267 yielded allelic p-values of 1.42 x 10(-7) and 2.57 x 10(-7), respectively with OR=1.50 (95% CI: 1.29-1.75). Risk region was delineated by SNPs rs10505477 and rs7014346 and comprised 17 kb

GWAS
SNP rs10505477
PubMedID [PMID 17618283]
Condition Colorectal cancer
Gene ORF DQ515897
Risk Allele A
pValue 3.00E-011
OR 1.17
95% CI 1.12-1.23


OMIM611469
DescCOLORECTAL CANCER, SUSCEPTIBILITY TO, 2; CRCS2
Variant
Relatedalso
[PMID 21102338OA-icon.png] Possible association between a genetic polymorphism at 8q24 and risk of upper gastrointestinal cancer

[PMID 21129217OA-icon.png] Characterization of the association between 8q24 and colon cancer: gene-environment exploration and meta-analysis


[PMID 21722176] Association of 8q24.21 locus with the risk of colorectal cancer: A systematic review and meta-analysis


[PMID 22505654] GWAS-identified colorectal cancer susceptibility loci associated with clinical outcomes


[PMID 17630503] Genetic variation in 8q24 associated with risk of colorectal cancer.


[PMID 18372901OA-icon.png] Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.


[PMID 18535017OA-icon.png] Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk.


[PMID 18577746OA-icon.png] Multiple loci with different cancer specificities within the 8q24 gene desert.


[PMID 18670647OA-icon.png] Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer.


[PMID 18973230OA-icon.png] Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations.


[PMID 19155440OA-icon.png] Meta association of colorectal cancer confirms risk alleles at 8q24 and 18q21.


[PMID 19520795OA-icon.png] Novel single nucleotide polymorphism associations with colorectal cancer on chromosome 8q24 in African and European Americans.


[PMID 20158306OA-icon.png] Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer.


[PMID 20437058OA-icon.png] The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer.


[PMID 21455501OA-icon.png] Genetic variants on chromosome 8q24 and colorectal neoplasia risk: a case-control study in China and a meta-analysis of the published literature.


GET Evidence
rs10505477
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.46875
summary



[PMID 23677573] Genome-wide association study identifies possible genetic risk factors for colorectal adenomas


[PMID 22848671OA-icon.png] Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.


[PMID 24854447] Association analysis of colorectal cancer susceptibility variants with gastric cancer in a Chinese Han population


[PMID 24978480] A Colorectal Cancer Susceptibility New Variant at 4q26 in the Spanish Population Identified by Genome-Wide Association Analysis