[PMID 18056436] Associated with risk of colorectal cancer; (P = 0.005)
[PMID 18839428] colorectal cancer rs10505477 and rs6983267 yielded allelic p-values of 1.42 x 10(-7) and 2.57 x 10(-7), respectively with OR=1.50 (95% CI: 1.29-1.75). Risk region was delineated by SNPs rs10505477 and rs7014346 and comprised 17 kb
[PMID 21102338] Possible association between a genetic polymorphism at 8q24 and risk of upper gastrointestinal cancer
[PMID 21129217] Characterization of the association between 8q24 and colon cancer: gene-environment exploration and meta-analysis
[PMID 21722176] Association of 8q24.21 locus with the risk of colorectal cancer: A systematic review and meta-analysis
[PMID 22505654] GWAS-identified colorectal cancer susceptibility loci associated with clinical outcomes
[PMID 17630503] Genetic variation in 8q24 associated with risk of colorectal cancer.
[PMID 18372901] Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.
[PMID 18535017] Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk.
[PMID 18577746] Multiple loci with different cancer specificities within the 8q24 gene desert.
[PMID 18670647] Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer.
[PMID 18973230] Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations.
[PMID 19155440] Meta association of colorectal cancer confirms risk alleles at 8q24 and 18q21.
[PMID 19520795] Novel single nucleotide polymorphism associations with colorectal cancer on chromosome 8q24 in African and European Americans.
[PMID 20158306] Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer.
[PMID 20437058] The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer.
[PMID 21455501] Genetic variants on chromosome 8q24 and colorectal neoplasia risk: a case-control study in China and a meta-analysis of the published literature.
|qualified_impact||Insufficiently evaluated pathogenic|
[PMID 23677573] Genome-wide association study identifies possible genetic risk factors for colorectal adenomas
[PMID 22848671] Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.