Rs1050283

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is asnp
is mentioned by
dbSNPrs1050283
hapmaprs1050283
hgdprs1050283
ensemblrs1050283
gopubmedrs1050283
scholarrs1050283
googlers1050283
pharmgkbrs1050283
hgvbaseg2prs1050283
medrefsnprs1050283
23andMers1050283
SNP Nexus

GeneOLR1
Chromosome12
Orientationminus
Position10203555
GenotypeEffect
rs1050283(C;C)increased risk for Alzheimer's
rs1050283(C;T)increased risk for Alzheimer's
rs1050283(T;T)normal risk


Genotypes Magnitude Summary
Rs1050283(C;C) increased risk for Alzheimer's
Rs1050283(C;T) increased risk for Alzheimer's
Rs1050283(T;T) 00 normal risk
rs1050283, a SNP also known as +1073, is located in the 3' untranslated region of the oxidized low density lipoprotein (lectin-like) receptor 1 OLR1 gene, which is also known as the LOX-1 gene.

The rs1050283(C) allele has been associated with increased risk for Alzheimer's disease in several studies of ~200 Southern Italian Alzheimer patients. The risk is independent of ApoE status, and may also be defined by haplotypes including one or both of neighboring SNPs rs12316150 and rs669.[PMID 15860461, PMID 18191876]

? (C;C) (C;T) (T;T)
Neighborrs12316150
Distance2