Rs10090154

From SNPedia

rs10090154 is a SNP in chromosome 8q24 "region 1", associated with increased risk for prostate cancer. The odds ratio for the (T) risk allele were 1.42 (CI: 1.07–1.87, p=0.014), and they were not significantly different between Caucasians and African-Americans in this study of ~500 patients.[PMID 18231127]

In follow-up studies looking at disease severity (and not just overall risk), this SNP is reported to account for the risk (from region 1) of advanced prostate cancer.[PMID 18231127]]

Note that a meta-analysis across 10+ studies, including over 15,000 prostate cancer cases, reported the risk for a different SNP (rs1447295) representing the same region, "region 1", of this chromosome.[PMID 1823127]

[PMID 19857256] Association between an 8q24 locus and the risk of colorectal cancer in Japanese

[PMID 19866473] Association of 17 prostate cancer susceptibility loci with prostate cancer risk in Chinese men