From SNPedia
spittoon rs1006737 or (rs2159100) Each T at this SNP increased the odds of bipolar disorder by 1.18 times compared to having two CC copies
| ? | (A;A) (A;G) (G;G) |
|---|
 |
| GWAS snp
|
| PMID
| [PMID 18711365]
|
| Trait
| Bipolar disorder
|
| Title
| Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
|
| Risk Allele
| A
|
| P-val
| 7E-8
|
| Odds Ratio
| 1.18 [NR]
|
Related to MAJOR AFFECTIVE DISORDER 1; MAFD1
according to
omim 125480. See
also
Related to MAJOR AFFECTIVE DISORDER 9; MAFD9
according to
omim 612372. See
also
[PMID 19621016] The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia
[PMID 19781653] Effect of CACNA1C rs1006737 on neural correlates of verbal fluency in healthy individuals
| PharmGKB | PA162355589 |
| Name | |
| Annotation | A genome-wide association analysis study in 4,387 cases and 6,209 controls identified a strong association of this variant in the CACNA1C gene with bipolar disorder. |
| Gene | CACNA1C |
| Featue | |
| Evidence | PubMed ID:18711365 |
| Drugs | |
| Diseases | Bipolar Disorder |
| Curation Level | Curated |
