Rs10010131

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Orientationplus
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ReferenceGRCh38 38.1/141
Chromosome4
Position6291188
GeneWFS1
is asnp
is mentioned by
dbSNPrs10010131
PheGenIrs10010131
nextbiors10010131
hapmaprs10010131
1000 genomesrs10010131
hgdprs10010131
ensemblrs10010131
gopubmedrs10010131
geneviewrs10010131
scholarrs10010131
googlers10010131
pharmgkbrs10010131
gwascentralrs10010131
openSNPrs10010131
23andMers10010131
23andMe allrs10010131
SNP Nexus

SNPshotrs10010131
SNPdbers10010131
MSV3drs10010131
GMAF0.2677
Max Magnitude
? (A;A) (A;G) (G;G) 28
OMIM125853
DescDIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM
Variant
Relatedalso
OMIM606201
DescWFS1 GENE; WFS1
Variant10010131
Relatedalso
[PMID 20028947OA-icon.png] Detailed investigation of the role of common and low frequency WFS1 variants in type 2 diabetes risk


[PMID 20361036OA-icon.png] Gene-gene interactions lead to higher risk for development of type 2 diabetes in an ashkenazi jewish population

[PMID 20802253OA-icon.png] Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion


OMIM606201
Desc
Variant10010131
Relatedalso
OMIM606201
Desc
Variant0021
Relatedalso
[PMID 22513821OA-icon.png] The association of genetic variants of type 2 diabetes with kidney function

[PMID 18040659OA-icon.png] Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations.

[PMID 18060660OA-icon.png] Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program.

[PMID 18426861OA-icon.png] Association analysis of type 2 diabetes Loci in type 1 diabetes.

[PMID 18591388OA-icon.png] Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.

[PMID 18694974OA-icon.png] Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study.

[PMID 18782870OA-icon.png] Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008.

[PMID 18984664] Common type 2 diabetes risk gene variants associate with gestational diabetes.

[PMID 19056611OA-icon.png] Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.

[PMID 19096518OA-icon.png] Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.

[PMID 19207020OA-icon.png] Meta-analysis in genome-wide association studies.

[PMID 19279076OA-icon.png] Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men.

[PMID 19324937OA-icon.png] Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults.

[PMID 19330314] A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion.

[PMID 19341491OA-icon.png] Genome-based prediction of common diseases: methodological considerations for future research.

[PMID 19455305OA-icon.png] No association of multiple type 2 diabetes loci with type 1 diabetes.

[PMID 19460916OA-icon.png] Genetic architecture of type 2 diabetes: recent progress and clinical implications.

[PMID 19502414OA-icon.png] Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.

[PMID 19526209OA-icon.png] Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

[PMID 19602701OA-icon.png] Underlying genetic models of inheritance in established type 2 diabetes associations.

[PMID 19862325OA-icon.png] PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.

[PMID 20017978OA-icon.png] Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study.

[PMID 20018041OA-icon.png] The effect of multiple genetic variants in predicting the risk of type 2 diabetes.

[PMID 20043853OA-icon.png] Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.

[PMID 20144327OA-icon.png] A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel.

[PMID 20509872OA-icon.png] Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population.

[PMID 20712903OA-icon.png] Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.

[PMID 21127832] Decreased insulin secretion and increased risk of type 2 diabetes associated with allelic variations of the WFS1 gene: the Data from Epidemiological Study on the Insulin Resistance Syndrome (DESIR) prospective study.

[PMID 21278902OA-icon.png] Genetic risk profiling for prediction of type 2 diabetes.

[PMID 22461567OA-icon.png] Diabetes-associated common genetic variation and its association with GLP-1 concentrations and response to exogenous GLP-1.


GET Evidence
rs10010131
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.627068
summary



[PMID 23257691] Association of rs734312 and rs10010131 polymorphisms in WFS1 gene with type 2 diabetes mellitus: a meta-analysis


[PMID 22996131OA-icon.png] Monogenic models: what have the single gene disorders taught us?


[PMID 23298195] Association study of genetic variants of 17 diabetes-related genes/loci and cardiovascular risk and diabetic nephropathy in the Chinese She population.