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From SNPedia

Geno Mag Summary
(A;A) 0 common/normal
(A;G) 0 normal
(G;G) 2 1.4x higher risk for meningiomas
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
dbSNP (classic)rs1801394
1000 genomesrs1801394
GWAS Ctlgrs1801394
Max Magnitude2
? (A;A) (A;G) (G;G) 28

rs1801394, also known as A66G or Ile22Met, is a SNP in the methionine synthase reductase MTRR gene. This gene encodes one of the two enzymes involved in the production of methionine (the other is MTR). The protein encoded by an rs1801394 allele has a lower affinity for MTR ([PMID 12416982]) and is inconsistently associated with homocysteine level, although it is a risk factor for neural tube defects ([PMID 10444342]) and Down syndrome ([PMID 10930360OA-icon.png]) in conditions of higher homocysteine.

Based on a study of British patients with primary brain tumors, (1,005 glioma cases and 631 meningioma cases), rs1801394(G;G) individuals were at higher risk for meningioma (odds ratio 1.41, CI: 1.02-1.94). In general, genotypes associated with increased 5,10-methylenetetrahydrofolate levels are associated with elevated risk for these types of brain cancer.[PMID 18483342]

[PMID 27342765OA-icon.png] Genetic impairments in folate enzymes increase dependence on dietary choline for phosphatidylcholine production at the expense of betaine synthesis

[PMID 19493349OA-icon.png] 118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects

[PMID 18682255] Arsenic metabolism is influenced by polymorphisms in genes involved in one-carbon metabolism and reduction reactions

[PMID 20883119] Common polymorphisms in six genes of the methyl group metabolism pathway and obesity in European adolescents

[PMID 21211571] MTHFR and MTRR genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from the Czech Republic


[PMID 22005284] Importance of gene variants and co-factors of folate metabolic pathway in the etiology of idiopathic intellectual disability

[PMID 21429654] Polymorphic variants of folate and choline metabolism genes and the risk of endometriosis-associated infertility

[PMID 22796266] Polymorphisms of tumor-related genes IL-10, PSCA, MTRR and NOC3L are associated with the risk of gastric cancer in the Chinese Han population

[PMID 17035141OA-icon.png] Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions.

[PMID 18191955OA-icon.png] Correlating observed odds ratios from lung cancer case-control studies to SNP functional scores predicted by bioinformatic tools.

[PMID 18199722] Dietary vitamin B6 intake and the risk of colorectal cancer.

[PMID 18203168OA-icon.png] Folate and one-carbon metabolism gene polymorphisms and their associations with oral facial clefts.

[PMID 18521744OA-icon.png] BRCA1 promoter methylation is associated with increased mortality among women with breast cancer.

[PMID 18708404OA-icon.png] B-vitamin intake, one-carbon metabolism, and survival in a population-based study of women with breast cancer.

[PMID 18708408OA-icon.png] Vitamins B2, B6, and B12 and risk of new colorectal adenomas in a randomized trial of aspirin use and folic acid supplementation.

[PMID 18936436OA-icon.png] Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.

[PMID 18992148OA-icon.png] Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.

[PMID 19064578OA-icon.png] No association of single nucleotide polymorphisms in one-carbon metabolism genes with prostate cancer risk.

[PMID 19336559OA-icon.png] Global DNA hypomethylation (LINE-1) in the normal colon and lifestyle characteristics and dietary and genetic factors.

[PMID 19376481OA-icon.png] One-carbon metabolism and breast cancer: an epidemiological perspective.

[PMID 19657388OA-icon.png] Lack of association between genetic polymorphisms in enzymes associated with folate metabolism and unexplained reduced sperm counts.

[PMID 19706844] Association of folate-pathway gene polymorphisms with the risk of prostate cancer: a population-based nested case-control study, systematic review, and meta-analysis.

[PMID 19776626OA-icon.png] Polymorphisms in methionine synthase, methionine synthase reductase and serine hydroxymethyltransferase, folate and alcohol intake, and colon cancer risk.

[PMID 20852008] Associations of folate, vitamin B12, homocysteine, and folate-pathway polymorphisms with prostate-specific antigen velocity in men with localized prostate cancer.

[PMID 21349258] Folate and choline metabolism gene variants and development of uterine cervical carcinoma.

[PMID 21688148OA-icon.png] Polymorphic variants of genes involved in homocysteine metabolism in celiac disease.

[PMID 22183302] Folate and choline metabolism gene variants in relation to ovarian cancer risk in the Polish population.

Risk Rs1801394(G;G)
Alt Rs1801394(G;G)
Reference Rs1801394(A;A)
Significance Other
Disease Neural tube defects Down syndrome not specified Gastrointestinal stromal tumor Methotrexate response - Toxicity/ADR Disorders of Intracellular Cobalamin Metabolism
Variation info
CLNDBN Neural tube defects, folate-sensitive, susceptibility to Down syndrome, susceptibility to not specified Gastrointestinal stromal tumor methotrexate response - Toxicity/ADR Disorders of Intracellular Cobalamin Metabolism
Reversed 0
HGVS NC_000005.9:g.7870973A>G
CLNSRC OMIM Allelic Variant PharmGKB Clinical Annotation UniProtKB (protein)
CLNACC RCV000007444.2, RCV000007445.2, RCV000126873.4, RCV000144926.1, RCV000211244.1, RCV000264714.1,

[PMID 23401104] Folate-genetics and colorectal neoplasia: what we know and need to know next

[PMID 24261678] MTRR A66G polymorphism and leukemia risk: evidence from published studies

[PMID 22021659OA-icon.png] Genetic variation throughout the folate metabolic pathway influences negative symptom severity in schizophrenia.

[PMID 22706675] Folic acid supplementation, MTHFR and MTRR polymorphisms, and the risk of childhood leukemia: the ESCALE study (SFCE).

[PMID 23560644] Polymorphisms in genes involved in the free-radical process in patients with sudden sensorineural hearing loss and Meniere's disease.

[PMID 26196053] Association between genetic polymorphisms in folate-related enzyme genes and infertile men with non-obstructive azoospermia

[PMID 28405167OA-icon.png] Genetic variants and increased risk of meningioma: an updated meta-analysis.

[PMID 28700981] Folate metabolism genetic polymorphisms and meningioma and glioma susceptibility in adults.

[PMID 28915669OA-icon.png] Folate metabolism genetic polymorphisms and meningioma and glioma susceptibility in adults.

[PMID 29392422] Association of main folate metabolic pathway gene polymorphisms with neural tube defects in Han population of Northern China.

[PMID 32124929OA-icon.png] SNPs  in folate pathway are associated with the risk of nonsyndromic cleft lip with or without cleft palate, a meta-analysis.