rs12807809
| Orientation | plus |
| Stabilized | plus |
| Make rs12807809(C;C) |
| Make rs12807809(C;T) |
| Make rs12807809(T;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 11 |
| Position | 124736389 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs12807809 |
| dbSNP (classic) | rs12807809 |
| ClinGen | rs12807809 |
| ebi | rs12807809 |
| HLI | rs12807809 |
| Exac | rs12807809 |
| Gnomad | rs12807809 |
| Varsome | rs12807809 |
| LitVar | rs12807809 |
| Map | rs12807809 |
| PheGenI | rs12807809 |
| Biobank | rs12807809 |
| 1000 genomes | rs12807809 |
| hgdp | rs12807809 |
| ensembl | rs12807809 |
| geneview | rs12807809 |
| scholar | rs12807809 |
| rs12807809 | |
| pharmgkb | rs12807809 |
| gwascentral | rs12807809 |
| openSNP | rs12807809 |
| 23andMe | rs12807809 |
| SNPshot | rs12807809 |
| SNPdbe | rs12807809 |
| MSV3d | rs12807809 |
| GWAS Ctlg | rs12807809 |
| GMAF | 0.213 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
- rs3131296(C) increased the odds of schizophrenia by 1.19x
- rs12807809(T) increased the odds of schizophrenia by 1.15x
- rs9960767(C) increased the odds of schizophrenia by 1.23 times.
[PMID 20673877] Although several of the SNPs reported in [PMID 19571808
] to be associated with increased risk for schizophrenia were replicated in this study of Han Chinese, rs12807809 did not (i.e. it was not found to be associated with increased risk in this study of ~2,500 Chinese patients).
| GWAS snp | |
|---|---|
| PMID | [PMID 19571808]
|
| Trait | Schizophrenia |
| Title | Common variants conferring risk of schizophrenia |
| Risk Allele | T |
| P-val | 2E-9 |
| Odds Ratio | 1.15 [NR] |
[PMID 21538840] Analysis of neurogranin (NRGN) in schizophrenia
[PMID 22461181] Functional genetic variation at the NRGN gene and schizophrenia: Evidence from a gene-based case-control study and gene expression analysis
[PMID 22253779] Impact of the Genome Wide Supported NRGN Gene on Anterior Cingulate Morphology in Schizophrenia
[PMID 20485477] New Genetic Findings in Schizophrenia: Is there Still Room for the Dopamine Hypothesis of Schizophrenia?
[PMID 21112188] A neuropsychological investigation of the genome wide associated schizophrenia risk variant NRGN rs12807809.
[PMID 22306195] Genetic and functional analysis of the gene encoding neurogranin in schizophrenia.
[PMID 24386483] Effects of the Neurogranin Variant rs12807809 on Thalamocortical Morphology in Schizophrenia
[PMID 21799211] The effect of neurogranin on neural correlates of episodic memory encoding and retrieval.
[PMID 22005930] Genome-wide association study of Alzheimer's disease with psychotic symptoms.
[PMID 24098564] The impact of genome-wide supported schizophrenia risk variants in the neurogranin gene on brain structure and function
[PMID 25739323] Influence of NRGN rs12807809 polymorphism on symptom severity in individuals with schizophrenia in the Han population but not the Zhuang population of south China
[PMID 28389239] Minor allele C of rs12807809 polymorphism in NRGN contributes to the severity of psychosis in patients with Schizophrenia in South Indian population.
[PMID 31861040] The association between rs12807809 polymorphism in neurogranin gene and risk of schizophrenia: A meta-analysis.
