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They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. It would be interesting if there was a connection to survival of those who contracted swine flu. My father, his brothers, and his sister were in an orphanage at the time and I know my aunt died there. John Lloyd Scharf 19:01, 8 October 2011 (UTC)