SOST
From SNPedia
| is a | gene |
| is | mentioned by |
| ClinVar | SOST |
| GeneCards | SOST |
| Diseases | SOST |
| wikipedia | SOST |
| SOST | |
| gopubmed | SOST |
| EVS | SOST |
| HEFalMp | SOST |
| MyGene2 | SOST |
| 23andMe | SOST |
| # SNPs | 4 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| rs104894644 | 0 | 43,755,612 | |
| rs104894645 | 0 | 43,755,608 | |
| rs387906320 | 3 | 43,758,672 | |
| rs387907169 | 0 | 43,758,681 |
Located on chromosome 17, the SOST gene encodes a protein called sclerostin. Sclerosis is a secreted glycoprotein produced primarily by osteocytes, and it has anti-anabolic effects on bone formation.Wikipedia
In 2001, scientists discovered that certain recessively inherited mutations in the SOST gene Afrikaner families gave rise to sclerosteosis, a severe sclerosing bone dysplasia disease characterized by progressive skeletal overgrowth. After many years of related research and drug development, in 2019 the FDA approved a drug to treat osteoporesis that mimics this type of SOST gene mutation.NY Times
