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From SNPedia

Make rs28362491(-;-)
Make rs28362491(-;ATTG)
Make rs28362491(ATTG;ATTG)
ReferenceGRCh38 38.1/141
GeneLOC105377621, NFKB1
is asnp
is mentioned by
dbSNP (classic)rs28362491
1000 genomesrs28362491
GWAS Ctlgrs28362491
Merged fromRs28720239
Max Magnitude0

rs28362491, also known as the -94 ATTG insertion/deletion polymorphism, is a SNP in the promoter (upstream) region of the NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 gene.

Several studies have seen differences between men and women for this SNP (such as [PMID 24818816OA-icon.png]), and others have seen differences between Asians and Caucasians (such as [PMID 24827594]). Any genotype summaries for this SNP should state which gender and ethnicity any summary is applicable to.

[PMID 19892748] Relationship between NFKB1 -94 insertion/deletion ATTG polymorphism and susceptibility of cervical squamous cell carcinoma risk

[PMID 20836841OA-icon.png] Polymorphisms in NFkB, PXR, LXR and risk of colorectal cancer in a prospective study of Danes

[PMID 22013908] NFKB1 -94 Insertion/Deletion ATTG Polymorphism Contributes to Risk of Systemic Lupus Erythematosus [PMID 19480714OA-icon.png] Functional polymorphism of the NFKB1 gene promoter is related to the risk of dilated cardiomyopathy.

{{PMID Auto |PMID=19734419 |Title=A polymorphism in NFKB1 is associated with improved effect of interferon-{alpha} maintenance treatment of patients with multiple myeloma after high-dose treatment with stem cell support. |OA=1 }}

[PMID 21245992OA-icon.png] Polymorphisms in NF-kappaB, PXR, LXR, PPARgamma and risk of inflammatory bowel disease.

[PMID 22614238] NFKB1 polymorphism is associated with age-related gene methylation in Helicobacter pylori-infected subjects.

[PMID 23806437] The functional -94 insertion/deletion ATTG polymorphism in the promoter region of NFKB1 gene increases the risk of sporadic colorectal cancer

[PMID 24578542OA-icon.png] Genetic polymorphism of NFKB1 and NFKBIA genes and liver cancer risk: a nested case-control study in Shanghai, China [PMID 22742859] NFKB1-94ATTG ins/del polymorphism (rs28362491) is associated with cardiovascular disease in patients with rheumatoid arthritis.

[PMID 22902396] The nuclear factor-kB functional promoter polymorphism is associated with endometriosis and infertility.

[PMID 23299027] The NFKB1 -94 ATTG insertion/deletion polymorphism (rs28362491) contributes to the susceptibility of congenital heart disease in a Chinese population.

[PMID 23357300] Role of inflammatory gene polymorphisms in left ventricular dysfunction (LVD) susceptibility in coronary artery disease (CAD) patients.

[PMID 23543433] Gene polymorphisms and thyroid function in patients with heart failure.

[PMID 24895544OA-icon.png] Association between NFKB1 -94ins/del ATTG Promoter Polymorphism and Cancer Susceptibility: An Updated Meta-Analysis

[PMID 24971461OA-icon.png] Polymorphisms in the Inflammatory Pathway Genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG Are Associated with Susceptibility of Inflammatory Bowel Disease in a Danish Cohort

[PMID 25223483] Effect of functional nuclear factor kappaB genetic polymorphisms on hepatitis B virus persistence and their interactions with viral mutations on the risk of hepatocellular carcinoma

[PMID 25304949] Role of Genetic Polymorphisms in NFKB-Mediated Inflammatory Pathways in Response to Primary Chemoradiation Therapy for Rectal Cancer

[PMID 25692306OA-icon.png] A Functional Insertion/Deletion Polymorphism in the Promoter Region of the NFKB1 Gene Increases the Risk of Papillary Thyroid Carcinoma

[PMID 26053525] Association of Pre-miRNA-499 rs3746444 and Pre-miRNA-146a rs2910164 Polymorphisms and Susceptibility to Behcet's Disease

[PMID 26075620OA-icon.png] Genetic Variation in NFKB1 and NFKBIA and Susceptibility to Coronary Artery Disease in a Chinese Uygur Population

[PMID 26563375] Association and interaction of NFKB1 rs28362491 insertion/deletion ATTG polymorphism and PPP1R13L and CD3EAP related to lung cancer risk in a Chinese population [PMID 26885097OA-icon.png] Association between genetic polymorphism in NFKB1 and NFKBIA and coronary artery disease in a Chinese Han population. [PMID 26919710] Variations in genes involved in regulation of the nuclear factor - κB pathway and the risk of acute myeloid leukaemia.

[PMID 27488439] Co-stimulatory CD28 and transcription factor NFKB1 gene variants affect idiopathic recurrent miscarriages.

[PMID 27525877] Association of NF-κB1 gene polymorphisms with coronary artery disease in a Han Chinese population.

[PMID 29664665] Genetic Variation in NFKB1 Gene Influences Liver Enzyme Levels in Morbidly Obese Women.

[PMID 30056167] Genetic variation on the NFKB1 genes associates with the outcomes of HCV infection among Chinese Han population.

[PMID 30910844OA-icon.png] NFKB1 gene rs28362491 polymorphism is associated with the susceptibility of acute coronary syndrome.

[PMID 31450925OA-icon.png] Gene Combination of CD44 rs187116, CD133 rs2240688, NF-κB1 rs28362491 and GSTM1 Deletion as a Potential Biomarker in Risk Prediction of Breast Cancer in Lower Northern Thailand.

[PMID 31826071] Interleukin 28 Polymorphisms and Hepatocellular Carcinoma Development after Direct Acting Antiviral Therapy for Chronic Hepatitis C.

[PMID 32441399] The possible role of NF-κB1 Rs28362491 polymorphism in male fertility of Egyptian population.

[PMID 32671985OA-icon.png] Inherited variant in NFκB-1 promoter is associated with increased risk of IBD in an Algerian population and modulates SOX9 binding.

[PMID 32851488] Nuclear factor NF-κB1 functional promoter polymorphism and its expression conferring the risk of Type 2 diabetes-associated dyslipidemia.

[PMID 31992083] IL1β, IL18, NFKB1 and IFNG gene interactions are associated with severity of rheumatoid arthritis: A pilot study.