Have questions? Visit https://www.reddit.com/r/SNPedia


From SNPedia

Make rs2569190(A;A)
Make rs2569190(A;G)
Make rs2569190(G;G)
ReferenceGRCh38 38.1/141
GeneCD14, TMCO6
is asnp
is mentioned by
dbSNP (classic)rs2569190
1000 genomesrs2569190
GWAS Ctlgrs2569190
Max Magnitude0
? (A;A) (A;G) (G;G) 28

rs2569190, also known as C260T, is a SNP in the CD14 gene.

[PMID 18727828OA-icon.png] rs2569190(C) (frequency = 39%) increased stroke risk among smokers (OR = 2.05, 95% CI=1.09-3.86, p=0.03), but not among non-smokers (OR = 0.93, 95% CI=0.62-1.39, p=0.72)

[PMID 18417506] rs1295685 and rs20541 were significantly associated with elevated IgE levels in pooled analyses. rs2569190(T;T) and rs2569191(C;C) genotypes associated with lower IgE

A meta-analysis of 7 studies (comprising a total of 1488 patients and 1600 control subjects) found no significant association between rs2569190 and cerebrovascular diseases.[PMID 19433913]

[PMID 19468702OA-icon.png] Functional impact of endotoxin receptor CD14 polymorphisms on transcriptional activity

[PMID 19701968OA-icon.png] Endotoxin receptor CD14 gene variants and histological features in chronic HCV infection

[PMID 19741468] Impact of Polymorphisms of TLR4/CD14 and TLR3 on Acute Rejection in Kidney Transplantation

[PMID 19830784OA-icon.png] Association of CD14 variant with prostate cancer in African American men

[PMID 19968655] The role of lipopolysaccharide in the development of atopy in humans

[PMID 20109750] Host-microbial interactions in childhood atopy: Toll-like receptor 4 (TLR4), CD14, and fecal Escherichia coli

[PMID 22015088] CD14 gene polymorphism is not associated with asthma but rather with bronchial obstruction and hyperreactivity in Slovenian children with non-atopic asthma

[PMID 15726497OA-icon.png] Gene-environment interaction effects on the development of immune responses in the 1st year of life.

[PMID 15867866] Polymorphisms in the 5' region of the CD14 gene are associated with eczema in young children.

[PMID 16614348] Endotoxin exposure, CD14, and allergic disease: an interaction between genes and the environment.

[PMID 16759385OA-icon.png] Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA).

[PMID 16820586OA-icon.png] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.

[PMID 16846490OA-icon.png] Lemierre's syndrome and genetic polymorphisms: a case report.

[PMID 17062130OA-icon.png] Polymorphisms within inflammatory genes and colorectal cancer.

[PMID 18987746OA-icon.png] Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination.

[PMID 19131662OA-icon.png] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.

[PMID 19263529OA-icon.png] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.

[PMID 19330901OA-icon.png] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.

[PMID 19337058OA-icon.png] CD14-159C/T and TLR9-1237T/C polymorphisms are not associated with gastric cancer risk in Caucasian populations.

[PMID 19559392OA-icon.png] A candidate gene association study of 77 polymorphisms in migraine.

[PMID 19759553OA-icon.png] Genetic and environmental risk factors for childhood eczema development and allergic sensitization in the CCAAPS cohort.

[PMID 20398919] CD14 polymorphisms and serum CD14 levels through childhood: a role for gene methylation?

[PMID 20463618OA-icon.png] Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.

[PMID 21320344OA-icon.png] Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population.

[PMID 21333644] C(-260)T polymorphism in the promoter of CD 14 gene is not associated with myocardial infarction in the Tunisian population.

[PMID 21389010] Endotoxin exposure, CD14 and wheeze among farmers: a gene--environment interaction.

[PMID 21596674OA-icon.png] Single nucleotide polymorphisms in the promoter of the gene encoding the lipopolysaccharide receptor CD14 are associated with bacterial diarrhea in US and Canadian travelers to Mexico.

[PMID 21885391] Respiratory health and endotoxin: associations and modification by CD14/-260 genotype.

[PMID 21996339] Opposite effects of allergy prevention depending on CD14 rs2569190 genotype in 3 intervention studies.

[PMID 22376040] Gene-gene interactions between candidate gene polymorphisms are associated with total IgE levels in Korean children with asthma.

[PMID 22494793] Innate immunity gene single nucleotide polymorphisms and otitis media

[PMID 23741383OA-icon.png] CD14 -159 C>T Gene Polymorphism with Increased Risk of Tuberculosis: Evidence from a Meta-Analysis

[PMID 23349936OA-icon.png] Determinants of serum concentrations of lipopolysaccharide-binding protein (LBP) in the adult population: the role of obesity

[PMID 24028589] TLR2, TLR3, TLR4 and CD14 gene polymorphisms associated with oral lichen planus risk

[PMID 22749237OA-icon.png] Tumor necrosis factor -308 polymorphism (rs1800629) is associated with mortality and ventilator duration in 1057 Caucasian patients.

[PMID 23459936OA-icon.png] Exploring the genetic basis of chronic periodontitis: a genome-wide association study.

[PMID 25394369OA-icon.png] The Association of Polymorphisms of TLR4 and CD14 Genes with Susceptibility to Sepsis in a Chinese Population

[PMID 25000179OA-icon.png] Genetic polymorphisms and sepsis in premature neonates

[PMID 25840711OA-icon.png] Interactions between innate immunity genes and early-life risk factors in allergic rhinitis

[PMID 26174031] TLR4 Asp299Gly polymorphism may be protective against chronic periodontitis

[PMID 26462562OA-icon.png] Multiplicative interaction of functional inflammasome genetic variants in determining the risk of gout

[PMID 24776844] Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease

[PMID 27277665OA-icon.png] Genetic risk factors for restenosis after percutaneous coronary intervention in Kazakh population.

[PMID 28829191] The CD14 rs2569190 TT Genotype is Associated with Chronic Periodontitis.

[PMID 29515128OA-icon.png] The CD14 (-159 C/T) SNP is associated with sCD14 levels and allergic asthma, but not with CD14 expression on monocytes.

[PMID 29687183] Single nucleotide polymorphisms of IL-13 and CD14 genes in allergic rhinitis: a meta-analysis.

[PMID 30288821] Early-life exposure to sibling modifies the relationship between CD14 polymorphisms and allergic sensitisation.

[PMID 30922395OA-icon.png] Effect of CD14 polymorphisms on the risk of cardiovascular disease: evidence from a meta-analysis.