rs2010963
Orientation | plus |
Stabilized | plus |
Make rs2010963(C;C) |
Make rs2010963(C;G) |
Make rs2010963(G;G) |
Reference | GRCh38 38.1/141 |
Chromosome | 6 |
Position | 43770613 |
Gene | VEGFA |
is a | snp |
is | mentioned by |
dbSNP | rs2010963 |
dbSNP (classic) | rs2010963 |
ClinGen | rs2010963 |
ebi | rs2010963 |
HLI | rs2010963 |
Exac | rs2010963 |
Gnomad | rs2010963 |
Varsome | rs2010963 |
LitVar | rs2010963 |
Map | rs2010963 |
PheGenI | rs2010963 |
Biobank | rs2010963 |
1000 genomes | rs2010963 |
hgdp | rs2010963 |
ensembl | rs2010963 |
geneview | rs2010963 |
scholar | rs2010963 |
rs2010963 | |
pharmgkb | rs2010963 |
gwascentral | rs2010963 |
openSNP | rs2010963 |
23andMe | rs2010963 |
SNPshot | rs2010963 |
SNPdbe | rs2010963 |
MSV3d | rs2010963 |
GWAS Ctlg | rs2010963 |
GMAF | 0.3434 |
Max Magnitude | 0 |
[PMID 19308252] Genetic variation in VEGF does not contribute significantly to the risk of congenital cardiovascular malformation
[PMID 19761764] Association between vascular endothelial growth factor gene polymorphisms and age-related macular degeneration in a Polish population
[PMID 19594543] Effect of vascular endothelial growth factor polymorphisms on survival in advanced-stage non-small-cell lung cancer
[PMID 19875757] Clinical relevance of vascular endothelial growth factor (VEGFA) and VEGF receptor (VEGFR2) gene polymorphism on the treatment outcome following imatinib therapy
[PMID 20082870] A Single Nucleotide Polymorphism in the Vascular Endothelial Growth Factor Gene Is Associated with Recurrence of Hepatocellular Carcinoma after Transplantation
[PMID 20132989] Phenotype and Genotype Characteristics of Age-related Macular Degeneration in a Japanese Population
[PMID 20209496] Possible association between polymorphisms of human vascular endothelial growth factor a gene and susceptibility to glioma in a Chinese population
[PMID 20489684] Vascular Endothelial Growth Factor Polymorphisms and Extent of Coronary Atherosclerosis in Chinese Population With Advanced Coronary Artery Disease
[PMID 20210775] The role of vascular endothelial growth factor gene as the genetic marker of atherothrombotic disorders and in the gene therapy of coronary artery disease
[PMID 20678803] Complement Factor H and High-Temperature Requirement A-1 Genotypes and Treatment Response of Age-related Macular Degeneration
[PMID 20847577] Vascular Endothelial Growth Factor Gene Polymorphisms and Risk of Neovascular Age-Related Macular Degeneration in a Chinese Cohort
[PMID 21316969] Polymorphisms of the vascular endothelial growth factor A gene and susceptibility to sporadic brain arteriovenous malformation in a Chinese population
[PMID 19653005] The combined impact of metabolic gene polymorphisms on elite endurance athlete status and related phenotypes
[PMID 22015057] Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study
[PMID 22129133] VEGFA and VEGFR2 genetic polymorphisms and survival in patients with diffuse large B cell lymphoma
[PMID 22209952] Vascular endothelial growth factor (VEGF) +405 C/G polymorphism is associated with essential hypertension in a population from Tehran of Iran
[PMID 22258388] Association of NOS2 and potential effect of VEGF, IL6, CCL2 and IL1RN polymorphisms and haplotypes on susceptibility to GCA--a simultaneous study of 130 potentially functional SNPs in 14 candidate genes
[PMID 22162628] Polymorphisms in the vascular endothelial growth factor gene and the risk of diabetic retinopathy in Chinese patients with type 2 diabetes
[PMID 22521084] Role of Vascular Endothelial Growth Factor Polymorphisms in the Treatment Success in Patients with Wet Age-related Macular Degeneration.
[PMID 22818823] Association of VEGF-A genetic polymorphisms with cancer risk and survival in advanced-stage oral squamous cell carcinoma patients
[PMID 15338501] Vascular endothelial growth factor gene polymorphisms in Behcet's disease.
[PMID 16142870] A functional variant of vascular endothelial growth factor is associated with severe ischemic complications in giant cell arteritis.
[PMID 16216669] Analysis of vascular endothelial growth factor (VEGF) functional variants in rheumatoid arthritis.
[PMID 16395752] Association between functional haplotypes of vascular endothelial growth factor and renal complications in Henoch-Schonlein purpura.
[PMID 16613616] Polymorphisms in the vascular endothelial growth factor gene and breast cancer in the Cancer Prevention Study II cohort.
[PMID 16645995] Vascular endothelial growth factor gene haplotypes in Kawasaki disease.
[PMID 16685110] Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population.
[PMID 17204151] VEGF, FGF1, FGF2 and EGF gene polymorphisms and psoriatic arthritis.
[PMID 17319747] Large-scale evaluation of candidate genes identifies associations between VEGF polymorphisms and bladder cancer risk.
[PMID 17601350] A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
[PMID 17625508] VEGF C-634G polymorphism is associated with protection from isolated ventricular septal defect: case-control and TDT studies.
[PMID 17917691] Genetic markers and biomarkers for age-related macular degeneration.
[PMID 17983459] Vascular endothelial growth factor (VEGF) gene (VEGFA) polymorphism can predict the prognosis in acute myeloid leukaemia patients.
[PMID 18281657] VEGF polymorphisms and survival in early-stage non-small-cell lung cancer.
[PMID 18378209] Vascular endothelial growth factor gene polymorphisms in age-related macular degeneration.
[PMID 18650217] Polymorphisms in the vascular endothelial growth factor gene and the risk of familial endometriosis.
[PMID 18780893] Genetic polymorphisms of VEGF, interactions with cigarette smoking exposure and esophageal adenocarcinoma risk.
[PMID 18805939] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.
[PMID 19026761] Molecular pathology of age-related macular degeneration.
[PMID 19041064] Vascular endothelial growth factor gene polymorphisms may predict the risk of acute graft-versus-host disease following allogeneic transplantation: preventive effect of vascular endothelial growth factor gene on acute graft-versus-host disease.
[PMID 19089753] Variation in the vascular endothelial growth factor gene, carotid intima-media thickness and the risk of acute myocardial infarction.
[PMID 19438866] Polymorphisms in genes involved in DNA repair, cell growth, oxidative stress and inflammatory response, and melanoma risk.
[PMID 19566948] Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer.
[PMID 19584152] Vascular endothelial growth factor polymorphisms and esophageal cancer prognosis.
[PMID 19587357] A systematic meta-analysis of genetic association studies for diabetic retinopathy.
[PMID 19603096] An analysis of growth, differentiation and apoptosis genes with risk of renal cancer.
[PMID 19628492] Polymorphism of the manganese superoxide dismutase gene but not of vascular endothelial growth factor gene is a risk factor for diabetic retinopathy.
[PMID 19755511] The role of vascular endothelial growth factor SNPs as predictive and prognostic markers for major solid tumors.
[PMID 19787077] Association of vascular endothelial growth factor polymorphisms with asthma in Tunisian children.
[PMID 19835575] The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer.
[PMID 20140301] VEGFA polymorphisms and cardiovascular anomalies in 22q11 microdeletion syndrome: a case-control and family-based study.
[PMID 20389299] Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.
[PMID 20444917] Association of vascular endothelial growth factor polymorphisms with nonproliferative and proliferative diabetic retinopathy.
[PMID 20621071] Functional vascular endothelial growth factor gene polymorphisms and diabetes: effect on coronary collaterals in patients with significant coronary artery disease.
[PMID 20706635] Human genetics of diabetic retinopathy: current perspectives.
[PMID 20832104] Vascular endothelial growth factor gene polymorphisms and ovarian cancer survival.
[PMID 21245770] Vascular endothelial growth factor gene polymorphisms and rheumatoid arthritis.
[PMID 21347390] Genetics of VEGF serum variation in human isolated populations of cilento: importance of VEGF polymorphisms.
[PMID 21362767] Interaction between smoking and polymorphism in the promoter region of the VEGFA gene is associated with ischemic heart disease and myocardial infarction in rheumatoid arthritis.
[PMID 21388351] Vascular endothelial growth factor A and cardiovascular disease in rheumatoid arthritis patients.
[PMID 21982816] Contribution of VEGF polymorphisms to variation in VEGF serum levels in a healthy population.
[PMID 22139971] Vascular endothelial growth factor (VEGF) gene polymorphisms may influence the efficacy of thalidomide in multiple myeloma.
[PMID 22307787] Pooled-analysis of the associations between three polymorphisms in the VEGF gene and age-related macular degeneration.
[PMID 22320189] Polymorphisms of the vascular endothelial growth factor gene and severe radiation pneumonitis in non-small cell lung cancer patients treated with definitive radiotherapy.
[PMID 22427559] Vascular endothelial growth factor gene polymorphisms and choroidal neovascularization in highly myopic eyes.
[PMID 22429695] Polymorphism in the vascular endothelial growth factor A (VEGFA) gene is associated with serum VEGF-A level and disease activity in rheumatoid arthritis: differential effect of cigarette smoking.
[PMID 23073296] VEGF Polymorphisms are not associated with an Increased Risk of Developing Renal Cell Carcinoma in Spanish population
[PMID 23211130] Polymorphisms in the vascular endothelial growth factor gene associated with recurrent spontaneous miscarriage
[PMID 22776467] Age at onset of rheumatoid arthritis: association with polymorphisms in the vascular endothelial growth factor A(VEGFA) gene and an intergenic locus between matrix metalloproteinase (MMP) 1 and 3 genes
[PMID 23490417] Single nucleotide polymorphism in the FLT4 gene is associated with atopic dermatitis in Koreans
[PMID 23511629] VEGF and VEGFR polymorphisms affect clinical outcome in advanced renal cell carcinoma patients receiving first-line sunitinib
[PMID 23673188] Vascular Endothelial Growth Factor gene (VEGFA) polymorphisms may serve as a prognostic factors for recurrent depressive disorder development
[PMID 23794399] VEGFA, FLT1, KDR and colorectal cancer: Assessment of disease risk, tumor molecular phenotype, and survival
[PMID 23848209] Vascular endothelial growth factor A (VEGFA) polymorphisms in Chinese patients with rheumatoid arthritis
[PMID 23880405] Methionine sulfoxide reductase A rs10903323 G/A polymorphism is associated with increased risk of coronary artery disease in a Chinese population
[PMID 24039754] The impact of polymorphic variations in the 5p15, 6p12, 6p21 and 15q25 Loci on the risk and prognosis of portuguese patients with non-small cell lung cancer
[PMID 24321896] Effect of Genetic Polymorphisms of Vascular Endothelial Growth Factor on Left Ventricular Hypertrophy in Patients With Systemic Hypertension
[PMID 24353087] Assessment of the associations between three VEGF polymorphisms and risk of prostate cancer
[PMID 22865486] Interaction among nitric oxide (NO)-related genes in migraine susceptibility.
[PMID 22915033] The C allele of -634G/C polymorphism in the VEGFA gene is associated with increased VEGFA gene expression in human retinal tissue.
[PMID 22925497] The relation of vascular endothelial growth factor (VEGF) gene polymorphisms on VEGF levels and the risk of vasoocclusive crisis in sickle cell disease.
[PMID 23007311] VEGF genetic polymorphisms affect the responsiveness to sildenafil in clinical and postoperative erectile dysfunction.
[PMID 23061744] Association of the vascular endothelial growth factor gene polymorphisms (-460C/T, +405G/C and +936T/C) with endometriosis: a meta-analysis.
[PMID 23064377] Influence of vascular endothelial growth factor single nucleotide polymorphisms on non-small cell lung cancer tumor angiogenesis.
[PMID 23353010] VEGF -634G>C polymorphism and diabetic retinopathy risk: a meta-analysis.
[PMID 23545315] Further evidence for the contribution of the vascular endothelial growth factor gene in coronary artery disease susceptibility.
[PMID 23553563] VEGFA SNPs and transcriptional factor binding sites associated with high altitude sickness in Han and Tibetan Chinese at the Qinghai-Tibetan Plateau.
[PMID 23644986] Genetic polymorphisms of vascular endothelial growth factor and risk for retinopathy of prematurity in South of Iran.
[PMID 24868559] The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies
[PMID 24652518] VEGFA and VEGFR2 gene polymorphisms and response to anti-vascular endothelial growth factor therapy: comparison of age-related macular degeneration treatments trials (CATT)
[PMID 25148899] Investigating the association of vascular endothelial growth factor polymorphisms with breast cancer: a Moroccan case-control study
[PMID 25239121] Variants in angiogenesis-related genes and the risk of clear cell renal cell carcinoma
ClinVar | |
---|---|
Risk | rs2010963(G;G) |
Alt | rs2010963(G;G) |
Reference | rs2010963(C;C) |
Significance | Other |
Disease | Microvascular complications of diabetes 1 |
Variation | info |
Gene | VEGFA |
CLNDBN | Microvascular complications of diabetes 1 |
Reversed | 0 |
HGVS | NC_000006.11:g.43738350C>G |
CLNSRC | OMIM Allelic Variant |
CLNACC | RCV000013007.2, |
[PMID 25713884] Serum cytokine levels in patients with colorectal cancers according to tumor stages and VEGF gene polymorphism
[PMID 24945674] Genetic variants of EGF and VEGF predict prognosis of patients with advanced esophageal squamous cell carcinoma
[PMID 25834741] Combination of Angiotensin Converting Enzyme Insertion/Deletion (I/D) (rs4646994) and VEGF Polymorphism (+405G/C; rs2010963) Synergistically Associated With the Development, of Albuminuria in Iranian Patients With Type 2 Diabetes
[PMID 25894981] Genetic Variations of VEGF Gene Were Associated with Tetralogy of Fallot Risk in a Chinese Han Population
[PMID 26002049] Polymorphisms in VEGFA gene affect the antihypertensive responses to enalapril
[PMID 26075076] Involvement of vascular endothelial growth factor -460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis
[PMID 26254278] Impact of VEGF, VEGFR, PDGFR, HIF and ERCC1 gene polymorphisms on thymic malignancies outcome after thymectomy
[PMID 26264619] Vascular endothelial growth factor polymorphisms and a synchronized examination of plasma and tissue expression in epithelial ovarian cancers
[PMID 26486233] Vascular endothelial growth factor (VEGF)-634G/C polymorphism was associated with severe pre-eclampsia and lower serum VEGF level
[PMID 24971577] Vascular endothelial growth factor A (VEGFA) gene polymorphisms have an impact on survival in a subgroup of indolent patients with chronic lymphocytic leukemia
[PMID 25714003] Association of VEGFA gene polymorphisms and VEGFA plasma levels with spontaneous preterm birth
[PMID 26535684] VEGF, eNOS, and ABCB1 genetic polymorphisms may increase the risk of osteonecrosis of the femoral head
[PMID 27116510] Effect of Risk Alleles in CFH, C3, and VEGFA on the Response to Intravitreal Bevacizumab in Tunisian Patients with Neovascular Age-related Macular Degeneration.
[PMID 27704620] The impact of vascular endothelial growth factor +405 C/G polymorphism on long-term outcome and severity of coronary artery disease.
[PMID 27648002] Regulatory SNPs Alter the Gene Expression of Diabetic Retinopathy Associated Secretary Factors.
[PMID 28651127] Vascular endothelial growth factor single nucleotide polymorphisms and haplotypes in pre-eclampsia: A case-control study.
[PMID 30393491] Association of common polymorphisms in the VEGFA and SIRT1 genes with type 2 diabetes-related traits in Mexicans.
[PMID 30746337] Association of Growth Factors Genes with Miscarriage.
[PMID 30843750] Genetic variants linked to folliculogenesis and successful pregnancy are not associated with twin births in a twins' town.
[PMID 31956063] Association between vascular endothelial growth factor gene polymorphisms and PCOS risk: A meta-analysis.
[PMID 32295184] MTHFR and VDR Polymorphisms Improve the Prognostic Value of MYCN Status on Overall Survival in Neuroblastoma Patients.
[PMID 32997825] VEGFR2 and VEGFA polymorphism are not associated with an inferior prognosis in Caucasian patients with aggressive B-cell lymphoma.
[PMID 33392836] Association between VEGF single nucleotide polymorphism and breast cancer in the Northern China Han population.