|?|| (G;G) (G;T) (T;T) ||28|
] A study of 201 Canadian ankylosing spondylitis
families concluded the ALPL (TNAP) haplotype G-G-T for SNPs rs3767155
, respectively, is significantly associated with the disease but only in men.
[PMID 18769922] A study of 353 Chinese ankylosing spondylitis patients found no significant difference in allele, genotype or haplotype frequencies for this SNP in either case-control or family-based association studies, which indicated that the TNAP (also known as ALPL) gene is unlikely to play a major role in the susceptibility to ankylosing spondylitis in the Chinese Han population.