rs13117307

Cervical cancer risk, GWAS Han Chinese population:

identified strong evidence of associations between cervical cancer and two new loci：

4q12 (rs13117307， Pcombined， stringently matched = 9.69 × 10E-09， per-allele odds ratio (OR) stringently matched = 1.26) and 17q12 (rs8067378， Pcombined， stringently matched = 2.00 × 10E-08， per-allele OR stringently matched = 1.18).

We additionally replicated an association between HLA-DPB1 and HLA-DPB2 (HLA-DPB1/2) at 6p21.32 and cervical cancer (rs4282438， Pcombined， stringently matched = 4.52 × 10E-27， per-allele OR stringently matched = 0.75).

[PMID 23817570] https://www.ncbi.nlm.nih.gov/pubmed/23817570

Orientation

plus

Stabilized

plus

Make rs13117307(C;C)

Make rs13117307(C;T)

Make rs13117307(T;T)

Reference

GRCh38 38.1/141

Chromosome

4

Position

55885574

Gene

EXOC1

is a	snp
is	mentioned by
dbSNP	rs13117307
dbSNP (old)	rs13117307
ClinGen	rs13117307
ebi	rs13117307
HLI	rs13117307
Exac	rs13117307
Gnomad	rs13117307
Varsome	rs13117307
Map	rs13117307
PheGenI	rs13117307
Biobank	rs13117307
1000 genomes	rs13117307
hgdp	rs13117307
ensembl	rs13117307
gopubmed	rs13117307
geneview	rs13117307
scholar	rs13117307
google	rs13117307
pharmgkb	rs13117307
gwascentral	rs13117307
openSNP	rs13117307
23andMe	rs13117307
23andMe all	rs13117307
SNP Nexus
SNPshot	rs13117307
SNPdbe	rs13117307
MSV3d	rs13117307
GWAS Ctlg	rs13117307

GMAF

0.1781

Max Magnitude

?	(C;C) (C;T) (T;T)	28

GWAS snp
PMID	[PMID 23817570]
Trait	Cervical cancer
Title	A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12.
Risk Allele	T
P-val	3E-10
Odds Ratio	1.28 [1.19-1.38]

[PMID 28505207] Immuno-related polymorphisms and cervical cancer risk: The IARC multicentric case-control study.

[PMID 28694212] Role of rs13117307 single nuclear polymorphism in the risk of uterine cervical cancer from Polish population and its impact on exocyst complex component 1 expression.