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From SNPedia

Isoniazid is a drug used for the treatment of both immediate and chronic tuberculosis. It is broken down by the liver through pathways including the NAT2 enzyme. NAT2 slow acetylators accumulate higher levels of isoniazid and are thereby at increased risk for liver damage.

Promethease evaluates an individual's NAT2 phenotype based on genosets gs138, gs139 and gs140.