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From SNPedia

Irinotecan is a drug used primarily in the treatment of colon cancer, and within the US, it is now marketed under the name Camptosar by Pfizer.

Side effects including severe diarrhea and neutropenia have been correlated to a variation in the UGT1A1 gene, which have led to FDA guidelines correlating the best dose of irinotecan to use depending on the patient's genotype.

Within the dbSNP database, there are multiple SNPs defining the same polymorphism; they are rs34815109, rs34983651, rs35600288 and rs5839491. About 10% of individuals in the US are homozygous for the higher risk SNP genotype.