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From SNPedia

Hypothyroidism, also called underactive thyroid or low thyroid, is a common disorder of the endocrine system in which the thyroid gland does not produce enough thyroid hormone. It can cause a number of symptoms, such as poor ability to tolerate cold, a feeling of tiredness, constipation, depression, and weight gain.Wikipedia

In Western countries, hypothyroidism occurs in 0.3–0.4% of people. Subclinical hypothyroidism, a milder form of hypothyroidism characterized by normal thyroxine levels and an elevated TSH level, is thought to occur in 4.3–8.5% of people. Hypothyroidism is more common in women than men, and people over the age of 60 are more commonly affected.Wikipedia

Most people with hypothyroidism symptoms and confirmed thyroxine deficiency are treated with a synthetic long-acting form of thyroxine, known as levothyroxine (L-thyroxine or L-T4). Combination therapy consisting of adding liothyronine (synthetic L-T3) to levothyroxine has been suggested as a measure to improve symptoms in unresponsive patients, especially for carriers of one or two rs225014(C) alleles, but this has not been confirmed by studies and is in general not currently recommended by national thyroid association guidelines.Wikipedia