At a minimum, these SNPs are known to be related, and others may also be
There are many known mutations in the ALDOB gene that cause hereditary fructosuria.
23andMe reports on the four most common mutations accounting for about 75% of the HFI-causing mutations in those of European ancestry:
- rs1800546, aka A149P, accounting for 65% of all HFI-causing mutations; 1% of all Brits carry a copy
- rs76917243 or i5008215, aka A174D; accounts for 11-14% of the HFI-causing mutations
- rs78340951 or i5012664, aka N334K; 5-8% of people with HFI
- i5012665, aka delta4E4; about 3% of the HFI-causing mutations