GEDmatch Eye Color SNPs

See also Eye_color

GEDMatch uses 41 SNPs and 61 rules active as of December 29th, 2017 to calculate a person's eye color. Below are the SNPs -- and alleles where known -- that GEDmatch uses.

AG rs10467971 Penetrance modifier - Blue
AA rs1105879 Reduces brown pigment to amber/brown gradient that is darkest around one's pupil.
CC rs1129038 High melanin production, often resulting in brownish eyes.
CT rs1129038 Medium melanin production, enough to add yellow to eyes.
TT rs1129038 Penetrance modifier - Blue
AA or AG rs11634406 Flecks (a.k.a. Nevi)
TT rs11636232 Increased density of anterior stroma; blocks melanin (i.e. lightens eye color); blocks blue (assumedly turning eyes grey).
CC rs11638069 Adds yellow (assumedly this means adding a small amount of eumelanin, thus appearing yellow, not actual yellow pigment / lipochrome).
CT rs12203592 Blue
CC rs12203592 No pigmented collarette (also tanning ability not lowered and hair and eye color not lightened).
GG rs12906280 Grey ring around outer edge of each eye (i.e. limbal rings)
AA rs12913832 High melanin production on anterior epithelium (i.e. brown pigment promotor not disabled, also higher chance of dark hair).
GG rs12913832 Low melanin. Blue eyes. (i.e. brown pigment promotor disabled)
TT rs13160471 Amber collarette.
AA rs1393350 Brown (conflicts with other studies, see SNPedia page)
TT rs1448485 Brown
GT rs1448485 Inhibits weak amber gradient
GG rs1448485 Light eyes
TT rs1470608 Large amounts of melanin on anterior epithelium
GT rs1470608 Medium melanin on anterior epithelium
TT rs1597196 Large amounts of melanin on anterior epithelium
GT rs1597196 Light to medium melanin production
CC rs1667394 Increased melanin production on anterior epithelium
CT rs1667394 Medium melanin production on anterior epithelium
TT rs1667394 Starburst (Collarette)
GG rs16891982 Starburst (Collarette)
CC rs17762363 Adds yellow
CT rs17762363 Increased melanin production
CT rs1800407 Penetrance modifier - Blue