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FLG

From SNPedia
is agene
is mentioned by
Full namefilaggrin
EntrezGene2312
PheGenI2312
VariationViewer2312
ClinVarFLG
GeneCardsFLG
dbSNP2312
DiseasesFLG
SADR2312
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wikipediaFLG
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EVSFLG
HEFalMpFLG
MyGene2FLG
23andMeFLG
UniProtP20930
EnsemblENSG00000143631
OMIM135940
# SNPs59
 Max MagnitudeChromosome positionSummary
rs10575179730152,310,881
rs10575181480152,309,656
rs10575182120152,303,358
rs10604995870152,313,983
rs10647936750152,311,049
rs10647959830152,304,695
rs10647961050152,305,164
rs10647962740152,311,980
rs1147335700152,315,363
rs1157463630152,312,410
rs1219096260152,307,225
rs1387264430152,307,547
rs1409803970152,308,956
rs1417841840152,309,169
rs1429914750152,313,823
rs1444194790152,311,957
rs1451198190152,313,060
rs1471452340152,308,647
rs1486069360152,303,434
rs1491055510152,309,494
rs1494849170152,304,939
rs1505974130152,305,146
rs1998852260152,314,107
rs1998952240152,311,129
rs2000022000152,308,777
rs2005197810152,311,565
rs2013565580152,304,661
rs2485518152,315,409
rs2786680152,325,202
rs31206490152,311,335
rs3126065152,303,083
rs3745887910152,307,622
rs3814299152,302,977
rs3814300152,303,164
rs3975075630152,311,184
rs413704460152,311,629
rs5287227130152,307,637
rs5352894220152,307,697
rs5468715920152,303,251
rs5582691373.9152,312,601
rs5781843150152,307,929
rs618167613.9152,313,385
rs741294470152,303,313
rs7455164340152,312,459
rs7490837590152,303,917
rs7548127420152,310,981
rs7569983120152,310,100
rs760831749
rs7612126720152,304,999
rs7618774210152,313,588
... further results

[PMID 16550169] - loss of function mutations in FLG, most commonly rs61816761 (R501X) or rs558269137 (2284del4), carried by ~9% of Europeans, strongly predisposed for atopic dermatitis "highly significant association with asthma occurring in the context of atopic dermatitis".

3x risk of peanut allergy http://www.cbc.ca/news/health/story/2011/03/11/peanut-allergy-gene.html

[PMID 18049447] - FLG mutations (R510X and 2284del4 genotyped) assoc. w/ nickel sensitivity and nickel sensitivity combined with jewelery intolerance, but not with other contact allergens, in a 1,502 strong subset of the KORA C study group.

considerably more information is available elsewhere. see wikipedia, a glut of PubMed-listed papers, and the FLG OMIM entry