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From SNPedia

An aneurysm is a localized ballooning in an artery due to a weak portion of the vessel wall. A ruptured aneurysm can cause hemorrhaging that is severely debilitating or fatal. The two most medically significant aneuryms occur at the base of the brain (intracranial aneurysms) and in the artery coming out of the heart (aortic aneurysms) Wikipedia. The most common type of aortic aneurysm is abdominal aortic aneurysm (AAA). Wikipedia

In 2014, a study found novel region on chromosome 7, near HDAC9, was associated with IA (rs10230207; P=4.14×10−8). See Stroke Journal 2014;45:3194-3199

In 2013, a meta-analysis confirmed 4 loci with robust association after random effects / sensitivity analysis. rs700651, rs9298506, rs10958409 and rs1333040. PMC3716358

As of 2010, at least 6 gene regions are known to be associated with increased risk for intracranial aneurysms in multiple ethnic groups, usually with multiple SNPs per region. [PMID 20364137], 23andMe blog

Reported and mapped genes and SNPs[edit]

GWAS Publications[edit]

[PMID 27899403OA-icon.png] Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci

[PMID 27418160OA-icon.png] Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms.

[PMID 27171184OA-icon.png] Genome-Wide Association Study Identifies Novel Susceptibility Genes Associated with Coronary Artery Aneurysm Formation in Kawasaki Disease.

[PMID 26434682OA-icon.png] Genetic variants in PLCB4/PLCB1 as susceptibility loci for coronary artery aneurysm formation in Kawasaki disease in Han Chinese in Taiwan.

[PMID 26186006OA-icon.png] Genetic Variants Underlying Risk of Intracranial Aneurysms: Insights from a GWAS in Portugal.