Alzheimer's disease, gene set
From SNPedia
[PMID 28323831] created a polygenic hazard score to arrive at age of onset of AD using the large IGAP dataset and other replications.
SNP | Chromosome | Gene | Minor Allele | Risk Allele | Beta log HR | Inside the gene? |
epsilon 2 | 19 | APOE | e2=0.07 | -- | -0.47 | Yes |
epsilon 4 | 19 | APOE | e4=0.14 | e4 | 1.03 | Yes |
rs4266886 | 1 | CR1 | T=0.1426/714 | T | -0.09 | intron |
rs61822977 | 1 | CR1 | A=0.4091/2049 | G | -0.08 | intron |
rs6733839 | 2 | BIN1 | T=0.3950/1978 | T | -0.15 | intron |
rs10202748 | 2 | INPP5D | C=0.2704/1354 | C | -0.06 | intron |
rs115124923 | 6 | HLA-DRB5 | A=0.1554/778 | A | 0.17 | No |
rs115675626 | 6 | HLA-DQB1 | A=0.1104/553 | A | -0.11 | No |
rs1109581 | 6 | GPR115 | T=0.2452/1228 | T | -0.07 | Intron |
rs17265593 | 7 | BCO43356 | T=0.2726/1365 | T | 0.23 | No |
rs259283 | 7 | BCO43356 | A=0.3385/1695 | C | 0.28 | Intron |
rs1476679 | 7 | ZCWPW1 | C=0.2115/1059 | C | 0.11 | Intron |
rs78571833 | 7 | AL833583 EPHA1-AS1 | C=0.0250/125 | C | 0.14 | Intron |
rs12679874 | 8 | PTK2B | G=0.4555/2281 | G | -0.09 | Intron |
rs2741342 | 8 | CHRNA2 | T=0.2941/1473 | T | 0.09 | Intron |
rs7831810 | 8 | CLU | A=0.4012/2009 | G | 0.09 | Intron |
rs1532277 | 8 | CLU | T=0.2360/1182 | T | 0.21 | Intron |
rs9331888 | 8 | CLU | G=0.3335/1670 | G | 0.16 | Intron |
rs7920721 | 10 | CR5950071 | G=0.2698/1351 | G | -0.07 | Intron |
rs3740688 | 11 | SPI1 | G=0.3608/1807 | G | 0.07 | Intron |
rs7116190 | 11 | MS4A6A | A=0.2879/1442 | A | 0.08 | No |
rs526904 | 11 | PICALM | T=0.3263/1634 | T | -0.20 | No |
rs543293 | 11 | PICALM | A=0.2923/1464 | A | 0.30 | No |
rs11218343 | 11 | SORL1 | C=0.1090/546 | C | 0.18 | Intron |
rs6572869 | 14 | FERMT2 | A=0.2754/1379 | A | -0.11 | Intron |
rs12590273 | 14 | SLC24A4 | C=0.0917/459 | C | 0.10 | Intron |
rs7145100 | 14 | abParts | C=0.1460/731 | C | 0.08 | Yes |
rs74615166 | 15 | TRIP4 | C=0.0074/37 | C | -0.23 | Intron |
rs2526378 | 17 | BZRAP1 | A=0.4722/2365 | G | 0.09 | Intron |
rs117481827 | 19 | C19orf6 | C=0.0469/235 | C | -0.09 | Yes, RNA noncoding |
rs7408475 | 19 | ABCA7 | G=0.2608/1306 | G | 0.18 | Intron |
rs3752246 | 19 | ABCA7 | G=0.1745/874 | G | -0.25 | 3' UTR |
rs7274581 | 20 | CASS4 | C=0.0940/471 | C | 0.10 | Intron |