| Geno
|
Mag
|
Summary
|
| (C;C)
|
|
<0.63x risk for restless legs
|
| (C;T)
|
|
0.63x risk for restless legs
|
| (T;T)
|
1
|
Normal risk of developing restless legs syndrome
|
rs9357271, a SNP located in the BTBD9 gene region, has been linked to a lower frequency of restless legs syndrome, a common sleep disorder, with an overall odds ratio of 0.63 (CI: 0.52-0.75) for the (C) minor allele. [PMID 17637780]
This SNP may also be associated with Tourette syndrome (TS), particularly TS without obsessive-compulsive disorder, based on a study of ~600 patients.[PMID 19822783]
| OMIM | 611185 |
| Desc | RESTLESS LEGS SYNDROME, SUSCEPTIBILITY TO, 6 |
| Variant | |
| Related | also |
| GWAS snp
|
| PMID
|
[PMID 21779176 ]
|
| Trait
|
|
| Title
|
Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.
|
| Risk Allele
|
T
|
| P-val
|
8E-22
|
| Odds Ratio
|
1.4700 [1.35-1.47]
|
[PMID 23361623] The BTBD9 gene may be associated with antipsychotic-induced restless legs syndrome in schizophrenia
[PMID 22914617] Analysis of the BTBD9 and HTR2C variants in Chinese Han patients with Tourette syndrome.
[PMID 26597663] Genetic factors influencing ferritin levels in 14,126 blood donors: results from the Danish Blood Donor Study
[PMID 28329290] Association of BTBD9 and MAP2K5/SKOR1 With Restless Legs Syndrome in Chinese Population.
]
