From SNPedia
This SNP (C/T) is in 5' region of the HLA-C gene, 35 kb away from transcription initiation in or around the HLA-C gene.
"People with this tiny sequence variation, dubbed rs9264942, appear to have up to 90% less virus in their systems than those who carry other polymorphisms.
About 10% of Europeans appear to carry two copies of rs9264942, which leads to an average 90% viral load reduction. About 50% of Europeans carry one copy, which gives a 60% reduction. By comparison, less than 40% of people of African descent appear to carry a single copy of the polymorphism."
Genetic variation may lower HIV load by 90%
They are referring to the (C;C) genotype giving a 90% reduction and the (C;T) giving a 60% reduction.
dbSNP page
This SNP is also reported [PMID 17641165] to account for 6.5% of the 15% variation in viral load set point in asymptomatic HIV infected individuals. rs2395029 can also be associated with reduced HIV viral load set point.
| ? | (C;C) (C;T) (T;T) |
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