Rs9264942

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is asnp
is mentioned by
dbSNPrs9264942
hapmaprs9264942
hgdprs9264942
ensemblrs9264942
gopubmedrs9264942
scholarrs9264942
googlers9264942
pharmgkbrs9264942
medrefsnprs9264942
23andMers9264942
Chromosome6
Position31382359
GenotypeEffect
rs9264942(C;C)90% reduction in HIV viral load
rs9264942(C;T)60% reduction in HIV viral load
rs9264942(T;T)normal
Genotypes Magnitude Summary
Rs9264942(C;C) 2.22.2
Rs9264942(C;T) 2.12.1
Rs9264942(T;T) 00

This SNP (C/T) is in 5' region of the HLA-C gene, 35 kb away from transcription initiation in or around the HLA-C gene.

"People with this tiny sequence variation, dubbed rs9264942, appear to have up to 90% less virus in their systems than those who carry other polymorphisms. About 10% of Europeans appear to carry two copies of rs9264942, which leads to an average 90% viral load reduction. About 50% of Europeans carry one copy, which gives a 60% reduction. By comparison, less than 40% of people of African descent appear to carry a single copy of the polymorphism." Genetic variation may lower HIV load by 90%

They are referring to the (C;C) genotype giving a 90% reduction and the (C;T) giving a 60% reduction. dbSNP page

This SNP is also reported [PMID 17641165] to account for 6.5% of the 15% variation in viral load set point in asymptomatic HIV infected individuals. rs2395029 can also be associated with reduced HIV viral load set point.

? (C;C) (C;T) (T;T)
Neighborrs10484554
Distance175
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