Rs9264942

This SNP (C/T) is in 5' region of the HLA-C gene, 35 kb away from transcription initiation in or around the HLA-C gene.

"People with this tiny sequence variation, dubbed rs9264942, appear to have up to 90% less virus in their systems than those who carry other polymorphisms. About 10% of Europeans appear to carry two copies of rs9264942, which leads to an average 90% viral load reduction. About 50% of Europeans carry one copy, which gives a 60% reduction. By comparison, less than 40% of people of African descent appear to carry a single copy of the polymorphism." Genetic variation may lower HIV load by 90%

They are referring to the (C;C) genotype giving a 90% reduction and the (C;T) giving a 60% reduction. dbSNP page

This SNP is also reported [PMID 17641165] to account for 6.5% of the 15% variation in viral load set point in asymptomatic HIV infected individuals. rs2395029 can also be associated with reduced HIV viral load set point.

GWAS snp
PMID	[PMID 20041166]
Trait	HIV-1 control
Title	Common Genetic Variation and the Control of HIV-1 in Human
Risk Allele
P-val	6E-12
Odds Ratio	NR NR

[PMID 21067287] Multiple sclerosis risk markers in HLA-DRA, HLA-C, and IFNG genes are associated with sex-specific childhood leukemia risk

GWAS snp
PMID	[PMID 21051598]
Trait
Title	The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation
Risk Allele	C
P-val	3E-35
Odds Ratio	2.9000 [NR]