Rs7923837
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs7923837 |
| hapmap | rs7923837 |
| hgdp | rs7923837 |
| ensembl | rs7923837 |
| gopubmed | rs7923837 |
| scholar | rs7923837 |
| rs7923837 | |
| pharmgkb | rs7923837 |
| medrefsnp | rs7923837 |
| 23andMe | rs7923837 |
| Chromosome | 10 |
| Position | 94471897 |
| Genotype | Effect |
|---|---|
| rs7923837(A;A) | 1x normal risk for T2D |
| rs7923837(A;G)* | 1.6x risk for T2D |
| rs7923837(G;G) | 3.2x risk for T2D |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs7923837(A;A) | 00 | |
| Rs7923837(G;G) | 22 |
rs7923837 is a SNP of the HHEX homeobox gene. In several studies, it has been associated with risk for type-2 diabetes (T2D).
In a study of 500 unrelated Caucasian T2D patients, the rs7923837(G) allele was overrepresented; the odds ratio was 1.57 (CI: 1.08-2.27, p=0.017). In this population, the population attributable risk for this allele was estimated to be 33%.[PMID 18231124]
In a study of ~400 Japanese T2D patients, rs7923837(G) was also associated with type-2 diabetes (odds ratio 1.66, CI: 1.28-2.15, p=0.00014). Heterozygous and homozygous carriers of the risk allele had odds ratios of 1.57 (95% CI 1.15-2.16, p=0.0050) and 3.16 (95% CI 1.40-7.16, p=0.0038) relative to non-carriers.[PMID 17971426]
[PMID 18477659] rs7923837 replicated as significant for type-2 diabetes risk in 1,900 Japanese patients, with odds ratio of 1.27 (CI: 1.13-1.43, p = 1.0 x 10e-4)
[PMID 19033397] This SNP was confirmed to be associated with type-2 diabetes in a study of 500+ Japanese patients plus pooled meta-analysis with 6 previous association studies (also of Japanese).
[PMID 19117022] rs7923837 and rs1111875 were significantly associated with decreased insulin secretion and lower insulinogenic index.
| ? | (A;A) (A;G) (G;G) |
|---|---|
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