From SNPedia
rs1111875 is a SNP of the
HHEX homeobox gene. In several studies, it has been associated with risk for
type-2 diabetes (T2D).
In a study of 500 unrelated Caucasian T2D patients, the rs1111875(G) allele was overrepresented; the odds ratio was 1.68 (CI: 1.19-2.35, p=0.003). In this population, the population attributable risk for this allele was estimated to be 36%.[PMID 18231124]
In a study of ~400 Japanese, rs1111875(G) was also associated with type-2 diabetes (odds ratio 1.42, CI: 1.13-1.78, p=0.0024). Heterozygous and homozygous carriers of the risk allele had odds ratios of 1.31 (CI: 0.97-1.77, p=0.0810) and 2.40 (CI: 1.34-4.32, p=0.0028) relative to non-carriers.[PMID 17971426]
And in a third study, 1,630 Japanese patients were also found to have this SNP significantly overrepresented (p=0.0064).[PMID 18162508]
[PMID 18477659] rs1111875 replicated as significant for type-2 diabetes risk in 1,900 Japanese patients, with odds ratio of 1.27 (CI: 1.14-1.40, p = 1.4 x 10e-5)
[PMID 18437351] 1,638 type 2 diabetes patients and 1,858 controls
- rs1111875 non-significant
[PMID 19117022] rs7923837 and rs1111875 were significantly associated with decreased insulin secretion and lower insulinogenic index. Reduced insulin clearance was also observed in heterozygous carriers of rs1111875
| ? | (A;A) (A;G) (G;G) |
|---|
 |
[PMID 19258437] A Genetic Variant in the IGF2BP2 Gene may Interact with Fetal Malnutrition on Glucose Metabolism.
| GWAS snp
|
| PMID
| [PMID 17463246]
|
| Trait
| Type 2 diabetes
|
| Title
| Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
|
| Risk Allele
| C
|
| P-val
| 6E-10
|
| Odds Ratio
| 1.13 [1.08-1.17]
|
| GWAS snp
|
| PMID
| [PMID 17463248]
|
| Trait
| Type 2 diabetes
|
| Title
| A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
|
| Risk Allele
| C
|
| P-val
| 6E-10
|
| Odds Ratio
| 1.13 [1.09-1.17]
|
| GWAS snp
|
| PMID
| [PMID 19401414]
|
| Trait
| Type 2 diabetes
|
| Title
| Confirmation of multiple risk loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population
|
| Risk Allele
| C
|
| P-val
| 7E-12
|
| Odds Ratio
| 1.21 [1.15-1.28]
|
Related to DIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM
according to
omim 125853. See
also
| PharmGKB | PA162168099 |
| Name | |
| Annotation | rs1111875 demonstrated association with Type 2 Diabetes in a GWAS of Finnish and Swedish patients and controls. |
| Gene | - |
| Featue | |
| Evidence | PubMed ID:17463246 |
| Drugs | |
| Diseases | Diabetes Mellitus, Type 2 |
| Curation Level | Curated |
[PMID 20041287] Polymorphisms of TCF7L2 and HHEX genes in Chinese women with polycystic ovary syndrome
