rs2108622
| Warfarin (Coumadin®) |
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 2 | lower warfarin dosing |
| (C;T) | None | |
| (T;T) | 2 | higher warfarin dosing |
| Reference | GRCh38 38.1/141 |
| Chromosome | 19 |
| Position | 15879621 |
| Gene | CYP4F2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs2108622 |
| dbSNP (classic) | rs2108622 |
| ClinGen | rs2108622 |
| ebi | rs2108622 |
| HLI | rs2108622 |
| Exac | rs2108622 |
| Gnomad | rs2108622 |
| Varsome | rs2108622 |
| LitVar | rs2108622 |
| Map | rs2108622 |
| PheGenI | rs2108622 |
| Biobank | rs2108622 |
| 1000 genomes | rs2108622 |
| hgdp | rs2108622 |
| ensembl | rs2108622 |
| geneview | rs2108622 |
| scholar | rs2108622 |
| rs2108622 | |
| pharmgkb | rs2108622 |
| gwascentral | rs2108622 |
| openSNP | rs2108622 |
| 23andMe | rs2108622 |
| SNPshot | rs2108622 |
| SNPdbe | rs2108622 |
| MSV3d | rs2108622 |
| GWAS Ctlg | rs2108622 |
| GMAF | 0.2153 |
| Max Magnitude | 2 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
| This SNP has been recognized by the Coriell Personalized Medicine Collaborative ICOB.
|
rs2108622 is a SNP in the cytochrome P450, family 4, subfamily F, polypeptide 2 CYP4F2 gene.
[PMID 18787519] In the males rs2108622(G) was significantly higher in cerebral infarction patients (P = 0.025)
[PMID 19207028] A study of Italian patients concluded that rs2108622(T;T) patients require 5.49 mg/day of warfarin versus 2.93 mg/day for (C;C) patients. Analysis of variance indicates that about 7% of mean weekly warfarin dose variance is explained by CYP4F2 genotype.
[PMID 19300499
] A Genome-Wide Association Study Confirms VKORC1, CYP2C9, and CYP4F2 as Principal Genetic Determinants of Warfarin Dose.
[PMID 19097922] A haplotype of the CYP4F2 gene associated with myocardial infarction in Japanese men.
| GWAS snp | |
|---|---|
| PMID | [PMID 19578179] |
| Trait | Acenocoumarol maintenance dosage |
| Title | A genome-wide association study of acenocoumarol maintenance dosage |
| Risk Allele | |
| P-val | 3E-10 |
| Odds Ratio | NR NR |
[PMID 19741565] Effects of CYP4F2 genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy
[PMID 20182420] A study of 370 Brazilian ("admixed") patients concludes that prospective CYP4F2 genotyping is of little value to these patients, presumably due to ethnic-based differences.
[PMID 20555338] Worldwide allele frequency distribution of four polymorphisms associated with warfarin dose requirements
| GWAS snp | |
|---|---|
| PMID | [PMID 20833655] |
| Trait | |
| Title | Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanese |
| Risk Allele | T |
| P-val | 3E-8 |
| Odds Ratio | None None |
[PMID 21084764] The influence of CYP4F2 rs2108622 (V433M) on warfarin dose requirement in Asian patients
[PMID 21127708] Genetic Variation of VKORC1 and CYP4F2 Genes Related to Warfarin Maintenance Dose in Patients with Myocardial Infarction
[PMID 21187935] Genes Involved in the Metabolism of Poly-Unsaturated Fatty-Acids (PUFA) and Risk for Crohn's Disease in Children & Young Adults
| GWAS snp | |
|---|---|
| PMID | [PMID 21729881]
|
| Trait | |
| Title | Genome-wide association study identifies common variants associated with circulating vitamin E levels. |
| Risk Allele | T |
| P-val | 1E-10 |
| Odds Ratio | 0.0300 [0.01-0.05] unit increase |
[PMID 22172097] CYP4F2 gene polymorphism as a contributor to warfarin maintenance dose in Japanese subjects
[PMID 22192158] Influence of CYP4F2 genotype on warfarin dose requirement-a systematic review and meta-analysis
[PMID 22549502] Effects of CYP4F2 Gene Polymorphisms on Warfarin Clearance and Sensitivity in Korean Patients With Mechanical Cardiac Valves
| GWAS snp | |
|---|---|
| PMID | [PMID 22437554]
|
| Trait | |
| Title | Genome-wide association study identifies three common variants associated with serologic response to vitamin E supplementation in men. |
| Risk Allele | T |
| P-val | 2E-7 |
| Odds Ratio | 0.0400 None |
[PMID 18535201] A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose.
[PMID 18778477] Genomic variation in myeloma: design, content, and initial application of the Bank On A Cure SNP Panel to detect associations with progression-free survival.
[PMID 18971550] Haplotype-based case-control study of the human CYP4F2 gene and essential hypertension in Japanese subjects.
[PMID 19955245] Warfarin sensitivity genotyping: a review of the literature and summary of patient experience.
[PMID 19957603] [Association on the haplotypes of CYP4F2 gene and myocardial infarction].
[PMID 20149073] Pharmacogenetics of acenocoumarol in patients with extreme dose requirements.
[PMID 20227456] CYP4F2 gene V433M polymorphism is associated with ischemic stroke in the male Northern Chinese Han population.
[PMID 20377871] SNP-RFLPing 2: an updated and integrated PCR-RFLP tool for SNP genotyping.
[PMID 20538623] Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver.
[PMID 20585445] A novel, single algorithm approach to predict acenocoumarol dose based on CYP2C9 and VKORC1 allele variants.
[PMID 20653676] CYP4F2 rs2108622: a minor significant genetic factor of warfarin dose in Han Chinese patients with mechanical heart valve replacement.
[PMID 21228733] Genetic and nongenetic factors associated with warfarin dose requirements in Egyptian patients.
[PMID 21562147] Identification of cytochrome P450 oxidoreductase gene variants that are significantly associated with the interindividual variations in warfarin maintenance dose.
[PMID 21625857] Association of 1347 G/A cytochrome P450 4F2 (CYP4F2) gene variant with hypertension and stroke.
[PMID 22010099] VKORC1 and CYP2C9 genotype and patient characteristics explain a large proportion of the variability in warfarin dose requirement among children.
[PMID 22486182] Influence of genetics and non-genetic factors on acenocoumarol maintenance dose requirement in Moroccan patients.
[PMID 22528326] Impact of CYP2C9*3, VKORC1-1639, CYP4F2rs2108622 genetic polymorphism and clinical factors on warfarin maintenance dose in Han-Chinese patients.
[PMID 23013706] Correlation between single nucleotide polymorphisms in CYP4F2 and warfarin dosing in chinese valve replacement patients
[PMID 23132553] Impact of the CYP4F2 p.V433M Polymorphism on Coumarin Dose Requirement: Systematic Review and Meta-Analysis
[PMID 23104259] Influence of warfarin dose-associated genotypes on the risk of hemorrhagic complications in Chinese patients on warfarin
| GWAS snp | |
|---|---|
| PMID | [PMID 23281178] |
| Trait | Metabolite levels |
| Title | A genome-wide assessment of variability in human serum metabolism. |
| Risk Allele | T |
| P-val | 9E-24 |
| Odds Ratio | NR NR |
[PMID 22676711] Pharmacogenomics of warfarin in populations of African descent.
[PMID 22892446] Influence of CYP4F2 polymorphisms and plasma vitamin K levels on warfarin sensitivity in Japanese pediatric patients.
[PMID 23061746] Impact of genetic factors (CYP2C9, VKORC1 and CYP4F2) on warfarin dose requirement in the Turkish population.
[PMID 23691226] Novel associations of VKORC1 variants with higher acenocoumarol requirements.
[PMID 24896259] Genome at Juncture of Early Human Migration: A Systematic Analysis of Two Whole Genomes and Thirteen Exomes from Kuwaiti Population Subgroup of Inferred Saudi Arabian Tribe Ancestry
[PMID 26176903] Interethnic variability of CYP4F2 (V433M) in admixed population of Roma and Hungarians
[PMID 27488176] Genetic determinants of warfarin maintenance dose and time in therapeutic treatment range: a RE-LY genomics substudy.
| ClinVar | |
|---|---|
| Risk | Rs2108622(T;T) |
| Alt | Rs2108622(T;T) |
| Reference | Rs2108622(C;C) |
| Significance | Drug-response |
| Disease | acenocoumarol response - Dosage warfarin response - Dosage phenprocoumon response - Dosage |
| Variation | info |
| Gene | CYP4F2 |
| CLNDBN | acenocoumarol response - Dosage warfarin response - Dosage phenprocoumon response - Dosage |
| Reversed | 0 |
| HGVS | NC_000019.9:g.15990431C>T |
| CLNSRC | PharmGKB Clinical Annotation |
| CLNACC | RCV000211144.1, RCV000211318.1, RCV000211328.1, |
[PMID 29273767] The rs2108622 polymorphism is related to the early risk of ischemic stroke in non-valvular atrial fibrillation subjects under oral anticoagulation.
[PMID 31505768] Circulating Vitamin E Levels and Risk of Coronary Artery Disease and Myocardial Infarction: A Mendelian Randomization Study.
[PMID 33437219] Influence of CYP4F2, ApoE, and CYP2A6 gene polymorphisms on the variability of Warfarin dosage requirements and susceptibility to cardiovascular disease in Jordan.
