Have questions? Visit https://www.reddit.com/r/SNPedia

rs2108622

From SNPedia

Warfarin (Coumadin®)
Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 2 lower warfarin dosing
(C;T) None
(T;T) 2 higher warfarin dosing
ReferenceGRCh38 38.1/141
Chromosome19
Position15879621
GeneCYP4F2
is asnp
is mentioned by
dbSNPrs2108622
ebirs2108622
Exacrs2108622
Maprs2108622
PheGenIrs2108622
hapmaprs2108622
1000 genomesrs2108622
hgdprs2108622
ensemblrs2108622
gopubmedrs2108622
geneviewrs2108622
scholarrs2108622
googlers2108622
pharmgkbrs2108622
gwascentralrs2108622
openSNPrs2108622
23andMers2108622
23andMe allrs2108622
SNP Nexus

SNPshotrs2108622
SNPdbers2108622
MSV3drs2108622
GWAS Ctlgrs2108622
GMAF0.2153
Max Magnitude2
? (C;C) (C;T) (T;T) 28
CPMC Logo.png

This SNP has been recognized by the Coriell Personalized Medicine Collaborative ICOB.
Additional information is available here

rs2108622 is a SNP in the cytochrome P450, family 4, subfamily F, polypeptide 2 CYP4F2 gene.

[PMID 18787519] In the males rs2108622(G) was significantly higher in cerebral infarction patients (P = 0.025)

[PMID 19207028] A study of Italian patients concluded that rs2108622(T;T) patients require 5.49 mg/day of warfarin versus 2.93 mg/day for (C;C) patients. Analysis of variance indicates that about 7% of mean weekly warfarin dose variance is explained by CYP4F2 genotype.


[PMID 19300499OA-icon.png] A Genome-Wide Association Study Confirms VKORC1, CYP2C9, and CYP4F2 as Principal Genetic Determinants of Warfarin Dose.

[PMID 19097922] A haplotype of the CYP4F2 gene associated with myocardial infarction in Japanese men.

OMIM122700
DescCOUMARIN RESISTANCE
Variant
Relatedalso
OMIM604426
DescCYTOCHROME P450, FAMILY 4, SUBFAMILY F, POLYPEPTIDE 2; CYP4F2
Variant
Relatedalso
GWAS snp
PMID [PMID 19578179]
Trait Acenocoumarol maintenance dosage
Title A genome-wide association study of acenocoumarol maintenance dosage
Risk Allele
P-val 3E-10
Odds Ratio NR NR

[PMID 19741565] Effects of CYP4F2 genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy


[PMID 20182420] A study of 370 Brazilian ("admixed") patients concludes that prospective CYP4F2 genotyping is of little value to these patients, presumably due to ethnic-based differences.


[PMID 20555338] Worldwide allele frequency distribution of four polymorphisms associated with warfarin dose requirements

GWAS snp
PMID [PMID 20833655]
Trait
Title Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanese
Risk Allele T
P-val 3E-8
Odds Ratio None None







[PMID 21084764] The influence of CYP4F2 rs2108622 (V433M) on warfarin dose requirement in Asian patients

[PMID 21127708OA-icon.png] Genetic Variation of VKORC1 and CYP4F2 Genes Related to Warfarin Maintenance Dose in Patients with Myocardial Infarction

[PMID 21187935OA-icon.png] Genes Involved in the Metabolism of Poly-Unsaturated Fatty-Acids (PUFA) and Risk for Crohn's Disease in Children & Young Adults

GWAS snp
PMID [PMID 21729881OA-icon.png]
Trait
Title Genome-wide association study identifies common variants associated with circulating vitamin E levels.
Risk Allele T
P-val 1E-10
Odds Ratio 0.0300 [0.01-0.05] unit increase


[PMID 22172097] CYP4F2 gene polymorphism as a contributor to warfarin maintenance dose in Japanese subjects


[PMID 22192158] Influence of CYP4F2 genotype on warfarin dose requirement-a systematic review and meta-analysis


[PMID 22549502] Effects of CYP4F2 Gene Polymorphisms on Warfarin Clearance and Sensitivity in Korean Patients With Mechanical Cardiac Valves

GWAS snp
PMID [PMID 22437554OA-icon.png]
Trait
Title Genome-wide association study identifies three common variants associated with serologic response to vitamin E supplementation in men.
Risk Allele T
P-val 2E-7
Odds Ratio 0.0400 None


[PMID 18535201OA-icon.png] A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose.


[PMID 18778477OA-icon.png] Genomic variation in myeloma: design, content, and initial application of the Bank On A Cure SNP Panel to detect associations with progression-free survival.


[PMID 18971550] Haplotype-based case-control study of the human CYP4F2 gene and essential hypertension in Japanese subjects.


[PMID 19955245OA-icon.png] Warfarin sensitivity genotyping: a review of the literature and summary of patient experience.


[PMID 19957603] [Association on the haplotypes of CYP4F2 gene and myocardial infarction].


[PMID 20149073] Pharmacogenetics of acenocoumarol in patients with extreme dose requirements.


[PMID 20227456] CYP4F2 gene V433M polymorphism is associated with ischemic stroke in the male Northern Chinese Han population.


[PMID 20377871OA-icon.png] SNP-RFLPing 2: an updated and integrated PCR-RFLP tool for SNP genotyping.


[PMID 20538623OA-icon.png] Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver.


[PMID 20585445OA-icon.png] A novel, single algorithm approach to predict acenocoumarol dose based on CYP2C9 and VKORC1 allele variants.


[PMID 20653676OA-icon.png] CYP4F2 rs2108622: a minor significant genetic factor of warfarin dose in Han Chinese patients with mechanical heart valve replacement.


[PMID 21228733OA-icon.png] Genetic and nongenetic factors associated with warfarin dose requirements in Egyptian patients.


[PMID 21562147OA-icon.png] Identification of cytochrome P450 oxidoreductase gene variants that are significantly associated with the interindividual variations in warfarin maintenance dose.


[PMID 21625857] Association of 1347 G/A cytochrome P450 4F2 (CYP4F2) gene variant with hypertension and stroke.


[PMID 22010099] VKORC1 and CYP2C9 genotype and patient characteristics explain a large proportion of the variability in warfarin dose requirement among children.


[PMID 22486182] Influence of genetics and non-genetic factors on acenocoumarol maintenance dose requirement in Moroccan patients.


[PMID 22528326] Impact of CYP2C9*3, VKORC1-1639, CYP4F2rs2108622 genetic polymorphism and clinical factors on warfarin maintenance dose in Han-Chinese patients.


[PMID 23013706OA-icon.png] Correlation between single nucleotide polymorphisms in CYP4F2 and warfarin dosing in chinese valve replacement patients


GET Evidence
CYP4F2-V433M
aa_change Val433Met
aa_change_short V433M
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.225507
summary Requires 1mg/day greater dose of warfarin.



[PMID 23132553OA-icon.png] Impact of the CYP4F2 p.V433M Polymorphism on Coumarin Dose Requirement: Systematic Review and Meta-Analysis


[PMID 23104259] Influence of warfarin dose-associated genotypes on the risk of hemorrhagic complications in Chinese patients on warfarin

GWAS snp
PMID [PMID 23281178]
Trait Metabolite levels
Title A genome-wide assessment of variability in human serum metabolism.
Risk Allele T
P-val 9E-24
Odds Ratio NR NR


[PMID 22676711OA-icon.png] Pharmacogenomics of warfarin in populations of African descent.


[PMID 22892446] Influence of CYP4F2 polymorphisms and plasma vitamin K levels on warfarin sensitivity in Japanese pediatric patients.


[PMID 23061746] Impact of genetic factors (CYP2C9, VKORC1 and CYP4F2) on warfarin dose requirement in the Turkish population.


[PMID 23691226OA-icon.png] Novel associations of VKORC1 variants with higher acenocoumarol requirements.


[PMID 24896259OA-icon.png] Genome at Juncture of Early Human Migration: A Systematic Analysis of Two Whole Genomes and Thirteen Exomes from Kuwaiti Population Subgroup of Inferred Saudi Arabian Tribe Ancestry


[PMID 26176903] Interethnic variability of CYP4F2 (V433M) in admixed population of Roma and Hungarians


[PMID 27488176] Genetic determinants of warfarin maintenance dose and time in therapeutic treatment range: a RE-LY genomics substudy.