Venlafaxine
From SNPedia
Venlafaxine, trade name Effexor, is a drug used to treat depression. It is primarily metabolized by CYP2D6, and to a smaller extent, CYP3A4.
Individuals who are CYP2D6 poor metabolizers, mostly individuals with two copies from among the alleles CYP2D6*4, CYP2D6*5, and CYP2D6*6, are at risk for more side effects (p<0.005) in comparison with other patients. These side effects include gastrointestinal problems such as nausea, vomiting and diarrhea. However, the efficacy of venlafaxine was the same regardless of CYP2D6 genotype.[PMID 16958828]
SNPs that influence how well this drug works based on a patients genotype(s) include:
