Tooth Development
Contents
Permanent tooth development[edit]
SNPs and genes[edit]
Some SNPs based on GWAS studiesː
SNPs in these genes are associated with permanent tooth development, according to GWAS studiesː
Publications[edit]
[PMID 21931568
] Genome-wide association study identifies four loci associated with eruption of permanent teeth.
Primary tooth development (number of teeth)[edit]
SNPs and genes[edit]
Some SNPs associated with primary tooth development (number of teeth), based on GWAS studiesː
- rs17101923
- rs12424086
- rs12229918
- rs11796357
- rs10932688
- rs10740993
- rs10506525
- rs9674544
- rs9316505
- rs8080944
- rs8079702
- rs7924176
- rs6504340
- rs6435957
- rs4844096
- rs2817937
- rs1994969
- rs1956529
- rs1799922
- rs997154
SNPs in these genes are associated with number of teeth development, according to GWAS studiesː
- ADK
- AJUBA
- AP3M1
- CACNB2
- CALU
- C14orf93
- DLEU7
- EDA
- FAM155E
- HMGA2
- HOXB1
- HOXB2
- IGF2BP1
- KCNJ2
- KCNJ16
- MSRB3
- OPN1SW
- RAD51L1
- VCL
Publications[edit]
[PMID 23704328] Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances.
Primary tooth development (time to first tooth eruption)[edit]
SNPs and genes[edit]
Some SNPs associated with time to first tooth eruption, based on GWAS studiesː
- rs17101923
- rs12424086
- rs12229918
- rs11796357
- rs10740993
- rs10506525
- rs9674544
- rs9386463
- rs8080944
- rs8079702
- rs7924176
- rs6568401
- rs5936487
- rs4937076
- rs1994969
- rs1799922
- rs997154
- rs412000
- rs17563
SNPs in these genes are associated with time to first tooth eruption, according to GWAS studiesː
Publications[edit]
[PMID 23704328] Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances.
Shovel-shaped incisors[edit]
SNPs and genes[edit]
SNPs
Genes
Publications[edit]
[PMID 22648185] Effects of an Asian-specific nonsynonymous EDAR variant on multiple dental traits.
[PMID 19804850] A common variation in EDAR is a genetic determinant of shovel-shaped incisors.
Tooth agenesis[edit]
Tooth agenesis (third molar) is counted as separate reported traits in GWAS studiesː
SNPs and genes[edit]
- rs1469622 Tooth agenesis, third molar
- rs938036 Tooth agenesis, mandibular third molar
- rs906628 Tooth agenesis, mandibular third molar
SNPs in these genes are associated with tooth agenesis, according to GWAS studiesː
Publications[edit]
[PMID 27365112] Mutations in MSX1, PAX9 and MMP20 genes in Saudi Arabian patients with tooth agenesis.
[PMID 24172245] A genome-wide association study of third molar agenesis in Japanese and Korean populations.
