rs964184

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(C;C)	0
(G;G)	2.2	increased risk of hypertriglyceridemia

Make rs964184(C;G)

Reference

GRCh38 38.1/141

Chromosome

11

Position

116778201

Gene

ZPR1

is a	snp
is	mentioned by
dbSNP	rs964184
dbSNP (classic)	rs964184
ClinGen	rs964184
ebi	rs964184
HLI	rs964184
Exac	rs964184
Gnomad	rs964184
Varsome	rs964184
LitVar	rs964184
Map	rs964184
PheGenI	rs964184
Biobank	rs964184
1000 genomes	rs964184
hgdp	rs964184
ensembl	rs964184
geneview	rs964184
scholar	rs964184
google	rs964184
pharmgkb	rs964184
gwascentral	rs964184
openSNP	rs964184
23andMe	rs964184
SNPshot	rs964184
SNPdbe	rs964184
MSV3d	rs964184
GWAS Ctlg	rs964184

GMAF

0.2002

Max Magnitude

2.2

?	(C;C) (C;G) (G;G)	28

GWAS snp
PMID	[PMID 19060906]
Trait	HDL cholesterol
Title	Common variants at 30 loci contribute to polygenic dyslipidemia
Risk Allele	G
P-val	1E-12
Odds Ratio	0.17 [0.11-0.23] SD decrease

GWAS snp
PMID	[PMID 20657596]
Trait	Hypertriglyceridemia
Title	Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia
Risk Allele	G
P-val	5E-24
Odds Ratio	3.28 [2.61-4.14]

GWAS snp
PMID	[PMID 20864672]
Trait
Title	Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease
Risk Allele	G
P-val	2E-11
Odds Ratio	0.03 [0.02-0.04] unit decrease

The rs964184(G;G) genotype is associated with hypertriglyceridemia. [PMID 20657596]

GWAS snp
PMID	[PMID 21378990]
Trait
Title	Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Risk Allele	G
P-val	1E-17
Odds Ratio	1.1300 [1.10-1.16]

GWAS snp
PMID	[PMID 21729881]
Trait
Title	Genome-wide association study identifies common variants associated with circulating vitamin E levels.
Risk Allele	G
P-val	8E-12
Odds Ratio	0.0400 [0.02-0.06] unit increase

GWAS snp
PMID	[PMID 22003152]
Trait
Title	Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies.
Risk Allele	C
P-val	8E-11
Odds Ratio	0.0320 None

GWAS snp
PMID	[PMID 20686565]
Trait
Title	Biological, clinical and population relevance of 95 loci for blood lipids.
Risk Allele	G
P-val	0
Odds Ratio	16.9500 None

[PMID 22399527] Genome-Wide Screen for Metabolic Syndrome Susceptibility Loci Reveals Strong Lipid Gene Contribution but No Evidence for Common Genetic Basis for Clustering of Metabolic Syndrome Traits

[PMID 21889769] Variants in the APOA5 gene region and the response to combination therapy with statins and fenofibric acid in a randomized clinical trial of individuals with mixed dyslipidemia

[PMID 22437554] Genome-Wide Association Study Identifies Three Common Variants Associated with Serologic Response to Vitamin E Supplementation in Men.

[PMID 22567092] MultiPhen: Joint Model of Multiple Phenotypes Can Increase Discovery in GWAS

GWAS snp
PMID	[PMID 22359512]
Trait
Title	Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
Risk Allele
P-val	2E-10
Odds Ratio	1.0000 None

[PMID 19656773] A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.

[PMID 19951432] Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.

[PMID 20160193] Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples.

[PMID 20339536] Genome-wide association of lipid-lowering response to statins in combined study populations.

[PMID 20385826] Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).

[PMID 23119086] Variants Identified in a GWAS Meta-Analysis for Blood Lipids Are Associated with the Lipid Response to Fenofibrate

[PMID 23404648] An association study between genetic polymorphisms related to lipoprotein-associated phospholipase A(2) and coronary heart disease

GWAS snp
PMID	[PMID 22916037]
Trait	Metabolite levels
Title	Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
Risk Allele
P-val	8E-20
Odds Ratio	NR NR

GWAS snp
PMID	[PMID 23505323]
Trait	Hypertriglyceridemia
Title	Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
Risk Allele
P-val	5E-35
Odds Ratio	1.77 [1.67-1.87]

GWAS snp
PMID	[PMID 23726366]
Trait	Triglycerides
Title	Genome-wide Characterization of Shared and Distinct Genetic Components that Influence Blood Lipid Levels in Ethnically Diverse Human Populations.
Risk Allele	G
P-val	4E-33
Odds Ratio	.16 [NR] unit increase

[PMID 24623848] Genetic Variants Reflecting Higher Vitamin E Status in Men Are Associated with Reduced Risk of Prostate Cancer

[PMID 22914552] APOA5 genotype modulates 2-y changes in lipid profile in response to weight-loss diet intervention: the Pounds Lost Trial.

[PMID 23832694] Common genetic variants associated with lipid profiles in a Chinese pediatric population.

GWAS snp
PMID	[PMID 24262325]
Trait	Coronary artery disease or ischemic stroke
Title	Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
Risk Allele
P-val	2E-5
Odds Ratio	NR NR

GWAS snp
PMID	[PMID 24097068]
Trait	Cholesterol, total
Title	Discovery and refinement of loci associated with lipid levels.
Risk Allele	C
P-val	3E-55
Odds Ratio	.12 [NR] unit decrease

GWAS snp
PMID	[PMID 24816252]
Trait	Blood metabolite levels
Title	An atlas of genetic influences on human blood metabolites.
Risk Allele	C
P-val	8E-15
Odds Ratio	.03 [0.019-0.031] unit decrease

GWAS snp
PMID	[PMID 24886709]
Trait	Triglycerides
Title	Amerindian-specific regions under positive selection harbour new lipid variants in Latinos.
Risk Allele	G
P-val	6E-33
Odds Ratio	1.89 [1.69-2.08]

[PMID 24989072] Association between the MLX interacting protein-like, BUD13 homolog and zinc finger protein 259 gene polymorphisms and serum lipid levels

[PMID 26405538] Association of FURIN and ZPR1 polymorphisms with metabolic syndrome

[PMID 26445370] Genetic Effects on Longitudinal Changes from Healthy to Adverse Weight and Metabolic Status - The HUNT Study

[PMID 26885234] Association study of BUD13-ZNF259 gene rs964184 polymorphism and hemorrhagic stroke risk.

[PMID 30275878] Direct and indirect genetic effects on triglycerides through omics and correlated phenotypes.

[PMID 31505768] Circulating Vitamin E Levels and Risk of Coronary Artery Disease and Myocardial Infarction: A Mendelian Randomization Study.

[PMID 31670185] Polymorphisms in genes that affect the variation of lipid levels in a Brazilian pediatric population with sickle cell disease: rs662799 APOA5 and rs964184 ZPR1.

[PMID 31796261] Contribution of genetic, biochemical and environmental factors on insulin resistance and obesity in Mexican young adults.

[PMID 31910446] Genome-wide association study of metabolic syndrome in Korean populations.

[PMID 32807694] The ZPR1 genotype predicts myocardial infarction in patients with familial hypercholesterolemia.

[PMID 33567543] Implication between Genetic Variants from APOA5 and ZPR1 and NAFLD Severity in Patients with Hypertriglyceridemia.