| Geno
|
Mag
|
Summary
|
| (G;G)
|
|
normal
|
| (G;T)
|
|
~2x higher risk for adverse drug reactions from cyclophosphamide treatments
|
| (T;T)
|
|
~2x higher risk for adverse drug reactions from cyclophosphamide treatments
|
| ? | (G;G) (G;T) (T;T) | 28 |
|---|
 |
is a SNP in the ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCC4 gene.
A stepwise case-control study of ~400 breast cancer Japanese patients receiving cyclophosphamide-based combination chemotherapy, roughly divided equally between those having or not having serious adverse drug reactions (ADRs), concluded that carriers of rs9561778(T) allele had a ~2x higher risk of ADRs. The ADRs for these patients tended to be gastrointestinal toxicity and leukopenia/neutropenia.[PMID 19696793]
| GET Evidence
|
| rs9561778
|
| aa_change
|
|
| aa_change_short
|
|
| impact
|
pharmacogenetic
|
| qualified_impact
|
Insufficiently evaluated pharmacogenetic
|
| overall_frequency
|
0.117188
|
| summary
|
|
