Rs9536314

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Orientationplus
Geno Mag Summary
(G;T) 2.7 Intelligence
(G;T) 2.5 intelligence; longevity
(T;T) 0 more common in all populations
ReferenceGRCh38 38.1/141
Chromosome13
Position33054001
GeneKL
is asnp
is mentioned by
dbSNPrs9536314
PheGenIrs9536314
nextbiors9536314
hapmaprs9536314
1000 genomesrs9536314
hgdprs9536314
ensemblrs9536314
gopubmedrs9536314
geneviewrs9536314
scholarrs9536314
googlers9536314
pharmgkbrs9536314
gwascentralrs9536314
openSNPrs9536314
23andMers9536314
23andMe allrs9536314
SNP Nexus

SNPshotrs9536314
SNPdbers9536314
MSV3drs9536314
GMAF0.1304
Max Magnitude2.7
? (G;G) (G;T) (T;T) 28
Venter snp
Source plos
Gene KL
allele G
frequency
sift AFFECT FUNCTION
HuRef 1103649192249
Disease Association Defects in KL may be a cause of chronic renal failure complications.



Neighborrs9527025
Distance55


[PMID 20394945] Infantile hypercalcemia and hypercalciuria: new insights into a vitamin D-dependent mechanism and response to ketoconazole treatment


[PMID 21565945OA-icon.png] Lack of association of Klotho gene variants with valvular and vascular calcification in Caucasians: a candidate gene study of the Framingham Offspring Cohort


[PMID 16753056OA-icon.png] The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians.


[PMID 18194558OA-icon.png] A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples.


[PMID 21695423OA-icon.png] Klotho locus, metabolic traits, and serum hemoglobin in hospitalized older patients: a genetic association analysis.


GET Evidence
KL-F352V
aa_change Phe352Val
aa_change_short F352V
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.170106
summary