|| worse cognitive function
|| intelligence; longevity
|| most common in all populations
|?|| (G;G) (G;T) (T;T) ||28|
|| AFFECT FUNCTION
| Disease Association
|| Defects in KL may be a cause of chronic renal failure complications.
[PMID 20394945] Infantile hypercalcemia and hypercalciuria: new insights into a vitamin D-dependent mechanism and response to ketoconazole treatment
[PMID 21565945] Lack of association of Klotho gene variants with valvular and vascular calcification in Caucasians: a candidate gene study of the Framingham Offspring Cohort
[PMID 16753056] The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians.
[PMID 18194558] A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples.
[PMID 21695423] Klotho locus, metabolic traits, and serum hemoglobin in hospitalized older patients: a genetic association analysis.
Variation in longevity gene KLOTHO is associated with greater cortical volumes
|| not reviewed
|| Insufficiently evaluated not reviewed