Rs9295536
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs9295536 |
| hapmap | rs9295536 |
| hgdp | rs9295536 |
| ensembl | rs9295536 |
| gopubmed | rs9295536 |
| scholar | rs9295536 |
| rs9295536 | |
| pharmgkb | rs9295536 |
| hgvbaseg2p | rs9295536 |
| medrefsnp | rs9295536 |
| 23andMe | rs9295536 |
| SNP Nexus |
| Gene | FLJ22536 |
| Chromosome | 6 |
| Orientation | plus |
| Position | 22131929 |
| Reference | GRCh37 37.1/131 |
| Genotype | Effect |
|---|---|
| rs9295536(A;A) | 2x increased risk for neuroblastoma |
| rs9295536(A;C) | possible increased risk for neuroblastoma |
| rs9295536(C;C) | normal |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs9295536(A;A) | 2x increased risk for neuroblastoma | |
| Rs9295536(A;C) | possible increased risk for neuroblastoma | |
| Rs9295536(C;C) | 00 | normal |
| ? | (A;A) (A;C) (C;C) | 28 |
|---|---|---|
|
| ||
SNPs clustered in one region of chromosome 6p22 have been linked to increased risk for the exceedingly rare childhood cancer known as neuroblastoma. A study involving 720 patients determined that rs9295536(A;A) genotypes had increased likelihood of neuroblastoma development (odds ratio 1.93, CI: 1.55 to 2.40, p=8 x 10-8). At-risk homozygotes diagnosed with neuroblastoma had, on average, more malignant clinical presentation, more aggressive disease, and poorer long-term survival.[PMID 18463370]
For more information on this cluster of SNPs, see rs6939340.
Related to NEUROBLASTOMA
according to omim 256700. See also
