Rs926103 is located within the SH2D2A gene on Chromosome 1. SH2D2A encodes an adapter protein thought to function in T-cell signal transduction. [PMID 11528519]
A study in the Journal for Neuroimmunology reported that 16 repeats repeat of GA after the (A;A) allele at this SNP is associated with multiple sclerosis in Norwegian, Danish and Swedish sample sets. [PMID 18554728]
The study concludes that the SH2D2A gene may contribute to susceptibility to MS. [PMID 18554728]
This study has yet to be verified or reproduced in any subsequent research.
[PMID 18554728] rs926103 and a GA repeat polymorphism forming a risk haplotype for Multiple sclerosis The fact that this is a mixture of a snp and a repeat makes this an interesting test case for Promethease
|qualified_impact||Insufficiently evaluated not reviewed|